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Anti-lung Cancer Mechanism of Natural Quinonoids
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 14, Pages: 32-44(2019)
- 作者机构：
上海中医药大学 基础医学院，经方理论应用研究中心，上海 201203
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20182134
CLC： R22; R242; R2-031; R285.5; R273Published：20 July 2019，
Published Online：23 August 2018，
Received：21 March 2018，
- 稿件说明：
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Hai-rong ZHONG, Chun-pu ZOU, Zi-hang XU. Anti-lung Cancer Mechanism of Natural Quinonoids. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(14):32-44(2019)
Hai-rong ZHONG, Chun-pu ZOU, Zi-hang XU. Anti-lung Cancer Mechanism of Natural Quinonoids. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(14):32-44(2019) DOI： 10.13422/j.cnki.syfjx.20182134.
摘要
肺癌是常见恶性肿瘤，具有高发病率、高死亡率的特点，放化疗目前仍是其主要治疗方式，但是放化疗带来的副作用不容忽视，亟需寻找毒性低，作用强并且对癌细胞具有靶向性的抗癌化合物，于是数量众多的天然产物来源化合物的抗癌作用受到越来越多的关注。他们结构多样，种类丰富但比天然植物成分简单，作用明确，这利于研究并且在应用时，富集的成分比天然植物的药理作用和临床疗效更强。醌类化合物属于天然生物活性分子，广泛存在于100多种高等和低等植物的各个部位中，包括萘醌、菲醌、苯醌和蒽醌，大多数具有抗肿瘤作用，它在许多癌症中都有应用和研究，其中在肺癌中的研究已经有很多，作用机制涉及多种途径，发挥促进凋亡、抑制增殖，诱导自噬，抑制血管生成和细胞侵袭迁移等多种作用，有些药物在与其他药物联用时还具有增强抗肿瘤作用的效果。随着研究的增多，许多合成的结构类似的醌类衍生物也增加了抗肺癌醌类化合物的多样可选性，醌类化合物在肺癌中具有广泛的应用前景。在查阅大量文献的基础上，现对目前醌类化合物抗肺癌的分子机制研究进行综述，总结不同作用的常见研究靶点，分析醌类化合物药理作用与抗肺癌作用之间的关系，提出可深入研究方向的思考，为后续其他醌类化合物的研究和开发作参考。
Abstract
Lung cancer is a common malignancy with a high morbidity and high mortality. Although chemoradiotherapy is still the main therapy
the side effects caused by radiotherapy and chemotherapy cannot be ignored. There is an urgent need to find a targeted anti-cancer compound with a low toxicity and strong effect. Therefore
a large number of natural product-derived compounds have received increasing attention for their anti-cancer effect. They are diverse in structure
rich in variety but simpler in composition than natural plants
with a clear efficacy. This facilitates research
and the enriched ingredients have stronger pharmacological effect and clinical efficacy than natural plants. Quinonoids are natural bioactive molecules that widely exist in more than 100 species of higher and lower plants
including naphthoquinones
phenanthrenequinones
benzoquinones and pyrenes. Most of them have anti-tumor effect. They are applied and studied in many cancers
especially lung cancer; and the mechanism of action involves multiple pathways
which play a role in promoting apoptosis
inhibiting proliferation
inducing autophagy
inhibiting angiogenesis and cell invasion and migration. When they are used in combination with other drugs
there is also an anti-tumor effect. With the development of researches
many synthetic quinonoid derivatives with similar structures also increase the diversity of anti-cancer steroids
and quinonoids have broad application prospects in lung cancer. On the basis of a large amount of literature
this article reviews current studies on the molecular mechanisms of antitumor activity of quinonoids
summarizes the common research targets with different effect
and analyzes the relationship between the pharmacological effects and anti-lung cancer effects of quinonoids
and proposes the direction of further research
so as to provide the reference for the follow-up research and development of other quinonoids.
关键词
天然醌类化合物抗肺癌机制
Keywords
natural quinonoidslung cancermechanism
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