Meng-han SUN, Zong-xiang TANG, Xiao-lin YUAN. Advances in Research on Antipruritic Effect of Xiaofengsan in Orthodox Manual of External Diseases. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):206-213(2019)
DOI:
Meng-han SUN, Zong-xiang TANG, Xiao-lin YUAN. Advances in Research on Antipruritic Effect of Xiaofengsan in Orthodox Manual of External Diseases. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):206-213(2019) DOI: 10.13422/j.cnki.syfjx.20190950.
Advances in Research on Antipruritic Effect of Xiaofengsan in Orthodox Manual of External Diseases
Itching is an unpleasant sensation that can cause physical and psychological discomfort. It often occurs in a variety of diseases. In addition to the common chemical medicines
the application of traditional Chinese medicines(TCMs) have attracted much attention for itch. As one of the classic antipruritic formula
Xiaofengsan is widely used by the later generations of doctors based on the edition of
Orthodox Manual of External Diseases
(
Wài Kē Zhèng Zōng
). It can be used to remove wind
dehumidify
clear heat and nourish blood by taking into account the complicated pathogenesis of skin diseases. In modern clinics
Xiaofengsan is commonly used for the treatment of rubella
eczema
acute and chronic urticaria
contact dermatitis
allergic dermatitis
psoriasis and other types of dermatitis with remarkable antipruritic effect. Its mechanism is related to its anti-allergic reaction
anti-allergy
anti-inflammatory
anti-histamine
immune regulation etc. This article reviews the research literature of Xiaofengsan and its addition and subtraction in modern pharmacological experimental research and clinical treatment in the past 15 years
and analyzes the current research situation of Xiaofengsan in the topic of antipruritic effect. The focus is on the compatibility characteristics of formula and the component study of single herb after being decomposed of Xiaofengsan
and the main material basis of antipruritic effect is summarized. It was found that Schizonepetae Herba
Saposhnikoviae Radix
Arctii Fructus
Cicadae Periostracum and Sophorae Flavescentis Radix were the main medicines for its antipruritic effect
which was helpful to expand the clinical value of Xiaofengsan and deepen its mechanisms of anti-itching.
关键词
消风散止痒作用实验研究临床应用组方规律物质基础《外科正宗》
Keywords
Xiaofengsanantipruritic effectexperimental researchclinical applicationprescription rulematerial basisOrthodox Manual of External Diseases
references
MU D, DENG J, LIU K F, et al. A central neural circuit for itch sensation [J].Science, 2017, 357(6352): 695-699.
Ständer S, Zeidler C, Magnolo N, et al. Clinical management of pruritus [J].J Dtsch Dermatol Ges, 2015, 13(2): 101-114.
Esser P R, Martin S F. Pathomechanisms of contact sensitization [J].Curr Allergy Asthma Rep, 2017, doi: 10.1007/s11882-017-0752-8http://doi.org/10.1007/s11882-017-0752-8.
Choi Y Y, Kim M H, Kim J H, et al. Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice [J].Phytother Res, 2013, 27(8): 1131-1135.
WANG B S, HUANG G J, TAI H M, et al. Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq. [J].Food Chem Toxicol, 2011, 50(3/4): 526-531.
CHUN J M, Kim H S, Lee A Y, et al. Anti-inflammatory and antiosteoarthritis effects of Saposhnikovia divaricata ethanol extract: in vitro and in vivo studies [J].Evid Based Complement Alternat Med, 2016, doi: 10.1155/2016/1984238http://doi.org/10.1155/2016/1984238.
ZHAO X Y, KAN Q C, ZHU L, et al. Matrine suppresses production of IL-23/IL-17 and ameliorates experimental autoimmune encephalomyelitis [J].Am J Chin Med, 2011, 39(5): 933-941.
LIU N, KAN Q C, ZHANG X J, et al. Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis [J].Exp Mol Pathol, 2014, 97(3): 470-476.