Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation

Mei-ge QI; Li LI; Lin QI; Jing SONG

doi:10.13422/j.cnki.syfjx.201912433

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Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation

Clinic | 更新时间：2021-02-09

- Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 14, Pages: 130-135(2019)
- 作者机构：
  
  青海大学　附属医院，西宁　 810001
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.201912433
  CLC： R271; R271.1; R273; R289
- Published：20 July 2019，
  
  Published Online：22 January 2019，
  
  Received：06 November 2018，
- 稿件说明：
扫描看全文
Mei-ge QI, Li LI, Lin QI, et al. Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(14):130-135(2019)
DOI：

Mei-ge QI, Li LI, Lin QI, et al. Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(14):130-135(2019) DOI： 10.13422/j.cnki.syfjx.201912433.

摘要

目的：

观察完带汤辨证治疗子宫内膜癌(EC)术后患者的症状、生活质量和免疫功能的影响，并从EC微环境的调控方面探讨了其作用机制。

方法：

将109例EC术后患者，采用随机按数字表法分为对照组54例和观察组55例。对照组术后根据不同分期给予放射治疗或(和)化疗；观察组在对照组治疗的基础上，采用完带汤辨证治疗，1剂/d。两组疗程均为连续治疗3个月。进行治疗前后症状、体征评分，进行癌症治疗前后功能评价量表(FACT-G)评分；检测治疗前后T淋巴细胞亚群(CD3

＋

，CD4

＋

，CD8

＋

，CD4

＋

/CD8

＋

)和自然杀伤细胞(NK)水平；检测治疗前后血管内皮生长因子(VEGF)，转化生长因子-

(TGF-

)，胰岛素样生长因子(IGF-1)，白细胞介素-17(IL-17)和IL-10水平。

结果：

治疗后观察组患者各症状、体征评分和总积分均低于对照组(

0.01)；观察组FACT-G量表各维度评分和总分均高于对照组(

0.01)；治疗后观察组NK，CD3

＋

，CD4

＋

和CD4

＋

/CD8

＋

均高于对照组(

0.01)，CD8

＋

低于对照组(

0.01)；治疗后观察组患者血清VEGF，TGF-

，IGF-1，IL-17和IL-10水平均低于对照组(

0.01)。

结论：

完带汤辨证治疗EC术后患者，可进一步改善患者的临床症状，提高患者生活质量和机体免疫功能，可改变子宫内膜癌肿瘤微环境，对患者多种细胞因子具有调节作用。

Abstract

Objective:

To observe the effect of syndrome differentiation and treatment with Wandaitang on symptoms

quality of life and function of immunologic after operation of endometrial carcinoma (EC)

in order to discuss the mechanism of action according to regulation of microenvironment of EC.

Method:

The 109 patients were divided into control group (54 cases) and observation group (55 cases) by random number table. Patients in control group got radiotherapy and/or chemotherapy according to different stages after operation. Patients in observation group were additionally given syndrome differentiation and treatment with Wandaitang

1 dose/day. And a course of treatment was 3 months. Before and after treatment

symptoms

sign

functional assessment of cancer therapy-general (FACT-G) were scored. And levels of T lymphocyte subsets (CD3

CD4

CD8

CD4

/CD8

)

natural killer cell (NK)

vascular endothelial growth factor (VEGF)

transforming growth factor-

(TGF-

)

insulin-like growth factor-1(IGF-1)

interleukin-17 (IL-17) and IL-10 were detected.

Result:

After treatment

the scores of symptoms

signs and total scores of the patients in the observation group were lower than the control group (

0.01). The scores of each dimension and total score of FACT-G scale in the observation group were higher than those in the control group(

0.01). After treatment

CD3

CD4

and CD4

/CD8

in the observation group were higher than those in the control group(

0.01)

lower than the control group(

0.01). After treatment

the serum levels of VEGF

TGF-

IGF-1

IL-17 and IL-10 in the observation group were lower than those in the control group.

Conclusion:

Wandaitang can ameliorate clinical symptoms

improve quality of life of patients and immune function of organism

regulate multiple cytokines

change the tumor microenvironment of endometrial carcinoma.

关键词

子宫内膜癌完带汤生活质量免疫功能肿瘤微环境

Keywords

endometrial carcinomaWandaitangquality of lifeimmune functiontumor microenvironment

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