Short-term and Long-term Efficacy of Modified Qingweisan in Treatment of Acute Pulpitis of Children with Syndrome of Hyperactivity of Gastric Fire

He-sheng WANG; Xing-an ZHANG; Da-qing WANG; Ling ZENG

doi:10.13422/j.cnki.syfjx.20191536

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Short-term and Long-term Efficacy of Modified Qingweisan in Treatment of Acute Pulpitis of Children with Syndrome of Hyperactivity of Gastric Fire

Clinic | 更新时间：2021-02-09

- Short-term and Long-term Efficacy of Modified Qingweisan in Treatment of Acute Pulpitis of Children with Syndrome of Hyperactivity of Gastric Fire
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 18, Pages: 95-100(2019)
- 作者机构：
  
  1.南充市中心医院，四川　南充　 637000；
  2.川北医学院　附属医院，四川　南充　 637600
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191536
  CLC： R289; R276; R276.8
- Published：20 September 2019，
  
  Published Online：11 April 2019，
  
  Received：04 March 2019，
- 稿件说明：
扫描看全文
He-sheng WANG, Xing-an ZHANG, Da-qing WANG, et al. Short-term and Long-term Efficacy of Modified Qingweisan in Treatment of Acute Pulpitis of Children with Syndrome of Hyperactivity of Gastric Fire. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):95-100(2019)
DOI：

He-sheng WANG, Xing-an ZHANG, Da-qing WANG, et al. Short-term and Long-term Efficacy of Modified Qingweisan in Treatment of Acute Pulpitis of Children with Syndrome of Hyperactivity of Gastric Fire. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):95-100(2019) DOI： 10.13422/j.cnki.syfjx.20191536.

摘要

目的：

观察清胃散加减治疗儿童急性牙髓炎(AP)胃火炽盛证的疗效及对炎症因子的影响。

方法：

将106例患儿按随机数字表法分为对照组52例和观察组54例。对照组采用一次性根管治疗术，术后给予阿奇霉素干混悬剂，10 mg·kg

－1

，顿服，连续使用3 d。观察组在对照组治疗的的基础上加服清胃散加减治疗，1剂/d，连续观察7 d。于治疗前及治疗后1，3，5，7 d评价疼痛视觉模拟评分(VAS)；于治疗前及治疗后3，7 d评价改良面部表情评分(FPS-R)；治疗后评价疼痛程度分级情况；记录疼痛减轻时间和咀嚼功能恢复正常时间；进行治疗前后中医证候评分；检测治疗前后C-反应蛋白(CRP)，肿瘤坏死因子-

(TNF-

)，白细胞介素-1

(IL-1

)，IL-6，降钙素基因相关肽(CGRP)和P物质(SP)水平；随访6个月记录成功或失败情况。

结果：

观察组患儿治疗后3，5，7 d的VAS评分均低于对照组(

0.01)；观察组患儿治疗后3，7 d的FPS-R评分均低于对照组(

0.01)；观察组患儿治疗后7 d疼痛程度轻于对照组(

0.05)；观察组患儿疼痛减轻时间和咀嚼功能恢复正常时间均短于对照组(

0.01)；观察组患儿中医证候评分均低于对照组(

0.01)；观察组患儿血清CRP，TNF-

，IL-1

，IL-6，CGRP和SP水平均低于对照组(

0.01)；经6个月的随访，观察组成功率为81.48%，对照组为78.85%，组间比较差异无统计学意义。

结论：

对于AP一次性根管治疗术后患儿采用清胃散加减内服治疗，近期能抑制炎症因子和疼痛递质的表达，可显著改善疼痛等症状，缩短病程，有着较好的近期疗效，随访成功率较好，但有待进一步的提高。

Abstract

Objective:

To observe the efficacy of modified Qingweisan on acute pulpitis (AP) of children with syndrome of hyperactivity of gastric fire and its effect on inflammatory factors.

Method:

One hundred and six patients were randomly divided into control group (52 cases) and observation group (54 cases) by random number table. Patients in control group got one-off root canal therapy

and azithromycin for suspension after the therapy for a continued 3 days

10 mg·kg

-1

3 times/days. In addition to the therapy of control group

patients in observation group were also given modified Qingweisan for 7 days

1 dose/day. Before treatment and at the 1

and 7

days after treatment

visual analogue scale (VAS)

faces rating scale-revised (FPS-R)

verbal rating scale and traditional Chinese medicine (TCM) syndrome were scored before and after treatment. And pain relief time and time for masticatory function returned to normal were recorded. And levels of C-reactive protein (CRP)

tumor necrosis factor-

(TNF-

)

interleukin-1

(IL-1

)

IL-6

calcitonin gene-related peptide (CGRP) and substance P were detected. And a 6-month follow-up was carried out to record the success or failure.

Result:

At the 3

and 7

days after treatment

score of VAS in observation group was lower than that in control group(

0.01). At the 3

and 7

days after treatment

score of FPS-R was lower than that in control group (

0.01). At the 7

days after treatment

degree of pain in observation group was lighter than that in control group (

0.05). Pain relief time and time for masticatory function returned to normal in observation group were shorter than those in control group (

0.01). Score of TCM syndrome was lower than that in in control group(

0.01). And levels of CRP

TNF-

IL-1

IL-6

CGRP and SP were all lower than those in control group(

0.01). According to 6-month follow-up

success rate in observation group was 81.48%

which was lower than 78.85%in control group

with no statistical significant difference between two groups.

Conclusion:

Modified Qingweisan can inhibit expressions of inflammatory factors and pain transmitters

ameliorate the pain and shorten course of disease among children after disposable root canal therapy

with a satisfactory short-term effect.

关键词

急性牙髓炎胃火炽盛证清胃散一次性根管治疗术炎症因子降钙素基因相关肽P物质

Keywords

acute pulpitissyndrome of hyperactivity of gastric fireQingweisandisposable root canal therapyinflammatory factorscalcitonin gene-related peptideSubstance P

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