Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern

Li-mei YUAN; Li-hua FAN; Zhi-guo ZHANG; Qing-hai LI

doi:10.13422/j.cnki.syfjx.20191834

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Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern

Clinic | 更新时间：2021-02-09

- Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 18, Pages: 89-94(2019)
- 作者机构：
  
  1.河南中医药大学，郑州　 450008；
  2.河南中医药大学　第三附属医院，郑州　 450008
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191834
  CLC： R289; R25; R256; R256.2
- Published：20 September 2019，
  
  Published Online：27 May 2019，
  
  Received：10 April 2019，
- 稿件说明：
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Li-mei YUAN, Li-hua FAN, Zhi-guo ZHANG, et al. Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):89-94(2019)
DOI：

Li-mei YUAN, Li-hua FAN, Zhi-guo ZHANG, et al. Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):89-94(2019) DOI： 10.13422/j.cnki.syfjx.20191834.

摘要

目的：

观察桃红四物汤合柴胡疏肝散加减治疗不稳定型心绞痛A型行为(气滞血瘀证)的疗效及对促炎因子和5-羟色胺(5-HT)表达的影响。

方法：

将124例患者随机分为对照组60例和观察组64例。对照组口服拜阿司匹林肠溶片，100 mg/次，1次/d；替格瑞洛片，90 mg/次，2次/d；酒石酸美托洛尔片，50 mg/次，2次/d；辛伐他汀片，10 mg/次，1次/d；心绞痛发作时舌下含服硝酸甘油片0.5 mg。观察组西医治疗同对照组，并给予桃红四物汤合柴胡疏肝散加减内服，1剂/d。两组疗程均为连续治疗8周。记录每周心绞痛发作次数、持续时间、疼痛程度和硝酸甘油使用情况；进行治疗前后心电图检测；检测治疗前后甘油三酯(TG)，总胆固醇(TC)，高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平；进行治疗前后西雅图心绞痛量表(SAQ)和气滞血瘀证评分；检测治疗前后白细胞介素-6(IL-6)，肿瘤坏死因子-

(TNF-

)，超敏C反应蛋白(hs-CRP)和5-HT水平。

结果：

经秩和检验；观察组心电图疗效优于对照组(

＝1.965，

0.05)；观察组心绞痛发作次数少于对照组，持续时间缩短于对照组，疼痛程度轻于对照组，硝酸甘油用量少于对照组(

0.01)；观察组SAQ量表各维度评分和SAQ总分均高于对照组(

0.01)；观察组气滞血瘀证各症状评分和总积分均低于对照组(

0.01)；观察组LDL-C低于照组(

0.01)，HDL-C高于对照组(

0.01)；观察组IL-6，hs-CRP，TNF-

和5-HT水平均低于对照组(

0.01)。

结论：

在常规西医治疗的基础上，采用桃红四物汤合柴胡疏肝散加减治疗不稳定型心绞痛(UAP)A型行为(气滞血瘀证)患者，可进一步控制心绞痛发作情况，减轻临床症状，提高生活质量，调节脂代谢，并可抑制促炎因子和5-HT表达，起到稳定病情的作用。

Abstract

Objective:

To observe the clinical efficacy of addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan to unstable angina pectoris with type A behavior pattern (Qi stagnation and blood stasis syndrome)

and investigate its effects on proinflammatory factors and serotonin (5-HT).

Method:

One hundred twenty-four patients were randomly divided into control group (60 cases) and observation group(64 cases) by random number table. Patients in control group got Aspirin enteric-coated tablets

100 mg/time

1 time/day. Tigrillo tablets

90 mg/time

2 times/days. Metoprolol tartrate tablets

50 mg/time

2 times/days. Simvastatin tablets

10 mg/time

1 time/day. Nitroglycerin tablets

0.5 mg/time. Based on the treatment in control group

patients in observation group also received addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan

1 dose/day. The treatment course was 8 weeks in both groups. Number of attacks

duration

degree of pain and usage of nitroglycerin were recorded for every week. Before and after treatment

electrocardiogram was also recorded. And levels of triglyceride (TG)

total cholesterol (TC)

high density lipoprotein cholesterol (HDL-C)

low density lipoprotein cholesterol (LDL-C)

interleukin-6 (IL-6)

tumor necrosis factor-

(TNF-

)

hypersensitive C-reactive protein and 5-HT were detected. In addition

scores of Seattle Angina Scale (SAQ) and Qi stagnation and blood stasis syndrome were graded.

Result:

In the rank sum test

the curative effect in electrocardiogram of observation group was better than that of control group (

=1.965

0.05). Number of attacks

duration

degree of pain and usage of nitroglycerin were all less than those in control group (

0.01). Scores of various dimensions in SAQ and the total scores of SAQ were all higher than those in control group (

0.01). Scores of various symptoms for Qi stagnation and blood stasis syndrome and the total scores were lower than those in control group (

0.01). Levels of LDL-C

IL-6

hs-CRP

TNF-

and 5-HT in observation group were lower than those in control group (

0.01)

while level of HDL-C was higher than that in control group (

0.01).

Conclusion:

On the basis of conventional western medicine

addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan can further control angina attack

relieve clinical symptoms

improve quality of life

regulate lipid metabolism

and can inhibit expression of proinflammatory factors and 5-HT

so it can play a role in stabilizing the disease.

关键词

不稳定型心绞痛A型行为气滞血瘀证桃红四物汤柴胡疏肝散促炎因子5-羟色胺

Keywords

unstable angina pectoristype A behavior patternQi stagnation and blood stasis syndromeTaohong SiwutangChaihu Shugansanproinflammatory factorsserotonin

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