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1.广西中医药大学 药学院,南宁 530001;
2.广西中医药大学 赛恩斯新医药学院,南宁 530200
Published:05 November 2019,
Published Online:04 July 2019,
Received:13 March 2019,
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Ben-tao LIU, Cai-ying YUAN, Jia-yong HUANG, et al. Research Progress on Chemical Constituents from Infructescence of Platycarya strobilacea and Their Pharmacological Activities. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):227-234(2019)
Ben-tao LIU, Cai-ying YUAN, Jia-yong HUANG, et al. Research Progress on Chemical Constituents from Infructescence of Platycarya strobilacea and Their Pharmacological Activities. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):227-234(2019) DOI: 10.13422/j.cnki.syfjx.20192006.
化香树果序源自于我国传统药用植物化香树的干燥果序,具有清热解毒、散风止痛、活血化淤、通窍排脓的功效,民间常用其治疗急慢性鼻炎、鼻窦炎以及急性上呼吸道感染等引起的各种并发症,是一种极具开发空间和利用价值的中药,拥有着广阔的市场前景。化香树果序中含有多种化学成分,主要包括挥发油类、酚类、黄酮类、萜类、糖类以及其他化合物,其中挥发油类成分居多但缺乏相关活性研究;酚类、黄酮类以及萜类化合物是其主要的活性成分,但目前这些成分仅有少数被分离鉴定得到。现代药理研究表明化香树果序具有抗肿瘤、抗病毒、抗炎抑菌、抗衰老、促生长、降压镇静等多方面药理活性,但现有研究主要以抗病毒、抗炎抑菌、抗肿瘤作用为主,其他方面的活性还不曾进行深入探究。在今后的研究中,应该深层次进行化香树果序化学成分及药理活性研究,并进一步明确其作用机制,使其得到更加充分合理的应用。该文通过在中国知网、维普、万方及PubMed等数据库查阅近年来国内外相关文献,将化香树果序化学成分、药理作用及临床应用等方面研究进行归纳、总结并对其研究进展概况加以阐述,以期为化香树果序的深入研究和进一步开发应用提供理论参考。
The infructescence of
Platycarya strobilacea
is the dry infructescence of
P
.
strobilacea
which is a traditional medicinal plant in China. It has functions of clearing up heat and detoxification
dispelling wind and relieving pain
activating blood circulation and removing stasis
clearing orifices and expelling pus. It is commonly used by people to treat various complications caused by acute and chronic rhinitis
sinusitis and acute upper respiratory tract infection
and is a kind of Chinese medicine with excellent development space and utilization value and has broad market prospects. There are many chemical constituents in the infructescence of
P
.
strobilacea
including volatile oils
Phenols
flavonoids
terpenoids
carbohydrates and other compounds. Among them
volatile oils are the most abundant
but lack of correlated activity studies. Phenolic compounds
flavonoids and terpenoids are the main pharmacogenetics constituents. However
few of these compounds have been isolated and identified. Modern pharmacological studies have shown that the infructescence of
P
.
strobilacea
has many pharmacological activities
such as anti-tumor
anti-virus
anti-inflammatory and bacteriostasis
anti-aging
growth promotion
hypotension and sedation
but the existing studies mainly focus on anti-virus
anti-inflammatory and bacteriostasis
anti-tumor effects
and other activities have not been further explored. In the future
the chemical constituents and pharmacological activities of the infructescence of
P
.
strobilacea
should be studied in depth
and its mechanism should be further clarified so that it can be more fully and reasonably applied. By consulting domestic and foreign literature in recent years in CNKI
VIP database
Wanfang date
PubMed and other databases. The chemical constituents
pharmacological effects and clinical application of the infructescence of
P
.
strobilacea
were summarized and expounded its research progress in order to provide theoretical reference for further research and further development and application of the Infructescence of
P
.
strobilacea
.
化香树果序挥发油酚类黄酮类抗肿瘤抗病毒抗炎抑菌
infructescence of Platycarya strobilacea; volatile oilsphenolflavonoidsantitumorantiviralanti-inflammatory and bacteriostatic
中国科学院西北植物研究所.秦岭植物志.第一卷[M].北京:科学出版社.1970.
冉先德.中华药海(下册)[M].哈尔滨:哈尔滨出版社,1993.
黄泰康.现代本草纲目(上卷)[M].北京:中国医药科技出版社,2001.
陈练洪.化香树果序中有效成分提取分离工艺研究[D].西安:西北大学,2006.
李亚萍,雷晓林.化香树果序的生药学研究[J].海峡药学,2009,21(5):73-75.
张小勇,张敏华.化香树果糖浆的制备与临床应用[J].中国医院药学杂志,1999,19(7):53-54.
王茂义,王军宪,贾晓妮,等.化香树果序挥发油化学成分分析[J].中国医院药学杂志,2011,31(9):736-738.
贾晓妮,王军宪,成昱霖,等.化香树果序化学成分研究[J].中药材,2016,39(8):1786-1788.
王立新,郭丕玲.化香树果穗的药理实验研究[J].西北药学杂志,2000,15(2):77.
姜醒,孙琦,朱景鑫,等.异型南五味子根茎中倍半萜类化学成分及其细胞毒活性[J].中国实验方剂学杂志,2017,23(9):46-50.
周燕园,韦志英,钟振国,等.GC-MS对广西细叶桉叶及果实挥发油成分研究[J].中药材,2009,32(2):216-219.
邓燚,李欣,邵萌,等.化香树果序挥发油的气相色谱-质谱联用分析及体外抗肿瘤活性研究[J].中医药导报,2013,19(11):80-82.
刘世彪,张代贵,姜业芳,等.湘西地区常见植物鉴别[M].长沙:湖南科学技术出版社,2006.
杨艳,周健,陈晓,等.圆果化香树中没食子酸的含量测定[J].中国实验方剂学杂志,2011,17(13):107-109.
ZHANG L, XU M, WANG Y M, et al. Optimizing ultrasonic ellagic acid extraction conditions from infructescence of Platycarya strobilacea using response surface methodology [J].Molecules, 2010, 15(11): 7923-7932.
ZHANG L, WANG Y, XU M. Acid hydrolysis of crude tannins from infructescence of Platycarya strobilacea Sieb. et Zucc to produce ellagic acid [J].Nat Prod Res, 2014, 28(19): 1637-1640.
石会丽,杨智峰,李芳,等.化香树果序薄层色谱鉴别及相关问题实验研究[J].西部中医药,2013,26(2):36-38.
王茂义,刘俊田,侯宁.RP-HPLC测定化香树果序中没食子酸的含量[J].中国药师,2010,13(3):378-379.
刘金坤,应敏,王琴,等.高效液相色谱法测定单叶化香树果序中没食子酸含量[J].中国药业,2018,27(6):4-7.
张亮亮,徐曼,汪咏梅,等.响应面优化化香树果序中鞣花酸超声波提取的研究[J].林产化学与工业,2011,31(2):19-24.
罗庆云,王汉忠.化香果化学成分的研究[J].南京林业大学学报:自然科学版,1983,7(2):123-130.
罗庆云,薛雨京,吴杏林.化香果水解产物的研究[J].林产化学与工业,1983,3(3):11-16.
冯辉明,傅畅金,董文生.化香果单宁及其有关化合物[J].南京林业大学学报:自然科学版,1989,13(4):56-59.
刘明霞.化香树果序中多酚提取纯化工艺及体外抑菌活性研究[D].西安:西北大学,2009.
高蓉,刘明霞,李稳宏,等.化香树果序多酚在大孔吸附树脂上吸附特性及热力学研究[J].离子交换与吸附,2010,26(6):542-550.
宋逍,巨红叶,胡坤霞,等.化香树果序多酚膜分离的动力学研究[J].天然产物研究与开发,2018,30(9):1634-1639.
徐曼,汪咏梅,张亮亮,等.响应面法优化化香树果序提取物的提取条件研究[J].林产化学与工业,2013,33(5):71-76.
ZHU J Y, TU W, ZENG C, et al. Mechanism of Platycarya strobilacea Sieb. et Zucc extract induced methuosis in human nasopharyngeal carcinoma CNE1 and CNE2 cells [J].J Southern Med Univ, 2017, 37(6): 827-832.
林亮.化香树果序黄酮类化合物提取、分离及抑菌活性研究[D].西安:西北大学,2009.
Choi Y H, Chae S G, Kim J H, et al. Isolation of an antifungal compound from aerial parts of Platycarya strobilacea [J].Hanguk Nonghwa Hakhoe Chi, 2003, 46(3): 268-270.
Lee J H, Kwon Y S, Kim C M, et al. Flavonoids from the stem bark of Platycarya strobilacea [J].Saengyak Hakhoechi, 1998, 29(4): 353-356.
Kim Y, Lee S H, Cho T S. Isolation of anticancer agents from the leaves of Platycarya strobilacea Sieb. et Zucc [J].Saengyak Hakhoechi, 1996, 27(3): 238-245.
Kim Y H, Kim K H, HAN C S, et al. Anti-wrinkle activity of Platycarya strobilacea extract and its application as a cosmeceutical ingredient [J].J Cosmet Sci, 2010, 61(3): 211-224.
Tanaka T, Kirihara S, Nonaka G, et al. Tannins and related compounds. CX X IV. Five new ellagitannins, platycaryanind A, B, C, and D, and platycariin, and a new complex tannin strobilanin, from the fruits and bark of Platycarya strobilacea Sieb. et Zucc, and biomimetic synthesis of C-glycosidic ellagitannins from glucopyranose-based ellagitannins [J].Chem Pharm Bull, 1993, 41(10): 1708-1716.
高蓉,陈练洪,李稳宏,等.超声法提取化香树果序中黄酮类化合物工艺[J].化学工程,2007,35(8):65-67,73.
高蓉,李稳宏,刘明霞,等.化香树果序中总黄酮不同提取方法对比研究[J].食品科学,2007,35(8):230-232.
高蓉,林亮,李稳宏,等.大孔吸附树脂纯化化香树果序总黄酮工艺研究[J].化学工程,2010,38(7):9-13.
李冬,李稳宏,廉媛媛,等.化香树果序总黄酮提取动力学研究[J].天然产物研究与开发,2011,23(4):689-692.
陈易彬,张益,陈奎.化香树果序多糖抗氧化性[J].食品科技,2010,35(2):141-143.
赵鹏,汪瑾,孟庆华,等.响应面法优化化香树果序多糖提取工艺及抗氧化性能研究[J].计算机与应用化学,2015,32(5):601-604.
高蓉.化香树果序活性成分提取、分离、应用及动力学研究[D].西安:西北大学,2009.
杨艳.分光光度法测圆果化香树的抗坏血酸含量[J].安徽农业科学,2010,38(18):9523-9524,9526.
陈奎.化香树果序化学成分研究[D].西安:陕西科技大学,2008.
李亚萍,莫志贤,曹露晔.化香树果序对EB病毒抗原表达的抑制作用及其细胞毒作用[J].今日药学,2014,24(2):93-95.
ZHANG L, WANG Y, XU M. In vitro antitumor activities of Platycarya strobilacea sieb.et Zucc infructescence extracts [J].Trop J Pharmacal Cal Res, 2014, 13(6): 849-854.
朱俊谕.化香树果序醇提物诱导人鼻咽癌细胞发生methuosis死亡的机制研究[D].广州:南方医科大学,2017.
刘金坤,应敏,敖利,等.化香树果序乙醇提取物调控RAS/MAPK通路对鼻咽癌细胞的影响[J].中国实验方剂学杂志,2018,24(20):145-152.
蔡红兵,刘金坤,范钦,等.巨泡式死亡:一种新的细胞死亡方式[J].南方医科大学学报,2013,33(12):1844-1847.
Ueno T, Miyanaga T, Kawakami F, et al. Further characterization of galloyl pedunculagin as an effective autophosphorylation inhibitor of C-kinase in vitro [J].Biol Pharm Bull, 2002, 25(11): 1401-1404.
Babu D, Lee J S, Park S Y, et al. Involvement of NF-kappa B in the inhibitory actions of Platycarya strobilacea on the TNF-alpha-induced monocyte adhesion to colon epithelial celiac and chemokine expression [J].Arch Pharm Res, 2008, 31: 725-735.
PANG J S, YEN J H, WU H T, et al. Gallic acid inhibited matrix invasion and AP-1/ETS-1-mediated MMP-1 transcription in human nasopharynxgeal carcinoma cells [J].Int J Mol Sci, 2017, 18(7): 1354.
SUN L, LI B, SU X, et al. An ursolic acid derived small molecule triggers cancer cell death through hyperstimulation of micropinocytosis [J].J Med Chem, 2017, 60(15): 6638-6648.
张峰,崔永华,曹平.槲皮素对人鼻咽癌HEN1细胞系增殖抑制和诱导凋亡作用的研究[J].临床耳鼻咽喉头颈外科杂志,2007,21(24):1136-9.
Primikyri A, Chatziathanasiadou M V, Karali E, et al. Direct binding of Bcl-2 family proteins by quercetin triggers its proapoptotic activity [J].ACS Chem Boil, 2014, 9(12): 2723-2741.
杜倩,汤洋,陈剑秋,等.槲皮素和白藜芦醇共载磁性固体脂质纳米粒的制备及其抑瘤作用评价[J].中国实验方剂学杂志,2019,25(10):109-114.
李庆,姚开,谭敏.新型天然抗氧化剂——鞣花酸[J].四川食品与发酵,2001,37(4):10.
Babu D, Lee J S, Park S Y, et al. Involvement of NF-kappa B in the inhibitory actions of Platycarya strobilacea on the TNF-alpha-induced monocyte adhesion to colon epithelial celiac and chemokine expression [J].Arch Phar Res, 2008, 31: 725-735.
Feresin G E, Tapia A, Gutierrez R A, et al. Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica [J].J Pharm Pharmacol, 2002, 54(6): 835-844.
潘美秀,刘声菊,刘国旗,等.HPLC测定绿茶浸出液灌胃动脉粥样硬化大鼠血浆中4个有效成分的含量[J].中国实验方剂学杂志,2017,23(8):92-97.
张亮亮,汪咏梅,徐曼,等.化香果序提取物对青石斑鱼生长性能的影响[J].饲料研究,2016,13:35-40.
尹江宁,汪华君,卢国元,等.熊果酸对糖尿病肾病大鼠足细胞损伤的保护作用[J].中国实验方剂学杂志,2018,24(17):132-138.
王波,余珊,何江波,等.熊果酸对RAW264.7巨噬细胞源性泡沫细胞胆固醇逆转运及对PPAR-γ的基因及蛋白表达的影响[J].中国实验方剂学杂志,2017,23(10):127-132.
汪青梅,肖伟洪,游秀丽.化香单宁净化有毒金属离子的研究[J].江西化工,2005,1:106-108.
胡新宇,汪咏梅,张亮亮,等.化香果单宁/聚N,N-二甲基丙烯酰胺水凝胶的制备及细胞黏附性能[J].林业工程学报,2017,2(6):37-44.
陈月婵.海步香菊片治疗慢性化脓性上颌窦炎178例疗效观察[J].贵阳中医学院学报,2000,22(2):28.
刘瑞清,董庆汉,孙希才,等.香菊片加罗红霉素治疗慢性副鼻窦炎280例疗效观察[J].云南中医中药杂志,2006,27(2):29.
童建松.香菊片治疗慢性鼻窦炎临床疗效观察[J].海峡药学,2010,22(10):126-128.
吴周强,李兴民,王文尊,等.香菊片治疗鼻窦炎的药理和临床研究(药理部分)[J].西北药学杂志,1989,4(2):8-10.
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