Mechanism of Borneolum Syntheticum Effect on Central Nervous and Vascular System Diseases

Dong-yu TAN; Jing-yu WANG; Wei-cong KANG; Yang YANG; Zhen YANG

doi:10.13422/j.cnki.syfjx.20192007

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Mechanism of Borneolum Syntheticum Effect on Central Nervous and Vascular System Diseases

Review | 更新时间：2021-02-09

- Mechanism of Borneolum Syntheticum Effect on Central Nervous and Vascular System Diseases
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 212-219(2019)
- 作者机构：
  
  1.河北中医学院　基础医学院，石家庄　 050200；
  2.北京中医药大学　中医学院，北京　 100029
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192007
  CLC： R2-0; R22; R285.5; R284
- Published：05 November 2019，
  
  Published Online：04 July 2019，
  
  Received：17 March 2019，
- 稿件说明：
扫描看全文
Dong-yu TAN, Jing-yu WANG, Wei-cong KANG, et al. Mechanism of Borneolum Syntheticum Effect on Central Nervous and Vascular System Diseases. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):212-219(2019)
DOI：

Dong-yu TAN, Jing-yu WANG, Wei-cong KANG, et al. Mechanism of Borneolum Syntheticum Effect on Central Nervous and Vascular System Diseases. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):212-219(2019) DOI： 10.13422/j.cnki.syfjx.20192007.

摘要

在传统中医药中，芳香开窍类的代表药物冰片常以“佐使”的功效广泛应用于神志类疾病的临床治疗。近年来，国内外很多学者通过对冰片的有效成分和药理作用进行深入的研究与分析，认为冰片的单独应用对于脑部疾病的作用显著。本文主要围绕冰片对脑循环系统以及中枢神经系统的作用机制展开论述。在抑制脑损伤方面，冰片可以降低神经元以血管内皮损伤，减轻脑水肿状态，降低缺血侧脑组织中Ca

2＋

的含量；在抗炎方面，冰片可以降低诱导型一氧化氮合酶(iNOS)和肿瘤坏死因子-

(TNF-

)的表达，减少白细胞浸润的数目、减少细胞间黏附分子-1(ICAM-1)阳性血管数和TNF-

阳性细胞数；在调节血脑屏障方面，冰片可提高微血管内皮细胞上紧密连接蛋白-1(ZO-1)和紧密连接因子-5(claudin-5)蛋白的表达量；冰片透皮吸收的强弱，可能与其构型、抽提脂质的能力以及亲水性相关；冰片提高他药的生物利用度的作用，在临床应用比较广泛；冰片的鼻内给药可绕过血脑屏障(BBB)，直达脑部中枢神经，在治疗脑血管病方面具有良好前景；在癫痫、阿尔茨海默病等脑部疾病的治疗方面，冰片的作用机制与其对各类脑神经递质如

-氨基丁酸(GABA)，甘氨酸(GLY)，天冬氨酸(ASP)及谷氨酸(GLU)，

-内啡肽(

-EP)，去甲肾上腺素(NE)，肾上腺素(E)，5羟色胺(5-HT)，多巴胺(DA)等密切相关，然而实验结果不尽相同，可能与冰片的不同给药剂量和时间有关，尚待研究。

Abstract

In traditional Chinese medicine

Borneolum Syntheticum

a representative drug of aromatic orifice

is often widely used in the clinical treatment of neurotic diseases.In recent years

many scholars at home and abroad have studied and analyzed the effective components and pharmacological effects of Borneolum Syntheticum

and it is considered that Borneolum Syntheticum alone has a significant effect on brain diseases.In this paper

the mechanism of Borneolum Syntheticum on cerebral circulatory system and central nervous system is discussed.In inhibiting brain injury

Borneolum Syntheticum can reduce neuronal vascular endothelial injury

reduce brain edema and decrease the content of Ca

in ischemic brain tissue.In the aspect of anti-inflammation

Borneolum Syntheticum can reduce the expression of induced nitric oxide synthase(iNOS) and tumor necrosis factor-

(TNF-

)

the number of leukocyte infiltration

the number of intercellular adhesion molecule-1(ICAM-1) positive vessels and the number of TNF-

positive cells.In regulating the blood-brain barrier

Borneolum Syntheticum can increase the expression of zonula occluden-1(ZO-1) and claudin-5 protein in microvascular endothelial cells.The strength of the transdermal absorption of the Borneolum Syntheticum may be related to its configuration

the ability to extract the lipid

and the hydrophilicity.The effect of Borneolum Syntheticum on improving the bioavailability of other drugs is widely used in clinic.Nasal administration of Borneolum Syntheticum can bypass blood-brain barrier (BBB)

and reach the central nervous system of the brain. It has a good prospect in the treatment of cerebrovascular disease.In the treatment of brain diseases such as seizures and Alzheimer's disease

the mechanism of Borneolum Syntheticum is closely related to its effect on various brain neurotransmitters such as

-aminobutyric acid(GABA)

glycine acid(GLY)

-aspartic acid(ASP)

glutamic acid(GLU)

-endorphin(

-EP)

norepinephrine(NE)

epinephrine(E)

5-hydroxytryptamine(5-HT)

dopamine(DA). However

the experimental results are not the same. It may be related to the different dosage and time of Borneolum Syntheticum administration

which needs to be studied.

关键词

冰片中枢神经系统脑循环系统非选择性阳离子通道综述机制

Keywords

Borneolum Syntheticumcentral nervous systemcerebral circulatory systemnon-selective cation channelreviewmechanism

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