Comprehensive Optimization of Rehabilitation Measures of Traditional Chinese Medicine to Elderly Patients with COPD at Stable Period

Yi CHENG; Liang FAN; Yue-hua LIN; Rong CHEN; Hai-ling ZHAO; Hui-fen HUANG

doi:10.13422/j.cnki.syfjx.20192133

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Comprehensive Optimization of Rehabilitation Measures of Traditional Chinese Medicine to Elderly Patients with COPD at Stable Period

Clinic | 更新时间：2021-02-09

- Comprehensive Optimization of Rehabilitation Measures of Traditional Chinese Medicine to Elderly Patients with COPD at Stable Period
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 24, Pages: 48-53(2019)
- 作者机构：
  
  海口市中医医院，海口　 570216
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192133
  CLC： R5; R56; R563; R563.5
- Published：20 December 2019，
  
  Published Online：31 July 2019，
  
  Received：02 July 2019，
- 稿件说明：
扫描看全文
Yi CHENG, Liang FAN, Yue-hua LIN, et al. Comprehensive Optimization of Rehabilitation Measures of Traditional Chinese Medicine to Elderly Patients with COPD at Stable Period. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(24):48-53(2019)
DOI：

Yi CHENG, Liang FAN, Yue-hua LIN, et al. Comprehensive Optimization of Rehabilitation Measures of Traditional Chinese Medicine to Elderly Patients with COPD at Stable Period. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(24):48-53(2019) DOI： 10.13422/j.cnki.syfjx.20192133.

摘要

目的：

探讨中医综合优化康复措施治疗老年COPD稳定期患者的临床疗效及对免疫功能和炎症因子的影响。

方法：

将144例患者随机按数字表法分为对照组和观察组各72例。对照组采用异丙托溴铵气雾剂，40～80 μg/次，2～4次/d，及沙美特罗替卡松粉吸入剂，1吸/d，2次/d；并给健康教育、氧疗和进行呼吸肌锻炼的综合西医治疗措施。观察组基础治疗同对照组，并给予中成药辨证内服、中药足浴和中医呼吸功能锻炼的中医综合优化康复措施。两组疗程均连续治疗6个月，并进行6个月随访。进行慢阻肺的综合评估；进行治疗前后改良版英国医学研究委员会呼吸问卷(mMRC)，慢阻肺患者自我评估测试(CAT)，第1秒用力呼气容积(FEV

)，FEV

占预计值百分比(FEV

%)，圣乔治呼吸问卷(SGRQ)和6 min 步行距离(6 MWD)评价；检测治疗前后T淋巴细胞亚群CD3

＋

，CD4

＋

，CD8

＋

，CD4

＋

/CD8

＋

水平；检测治疗前后血清白细胞介素-6(IL-6)，IL-8，肿瘤坏死因子-

(TNF-

)和超敏C反应蛋白(hs-CRP)水平。

结果：

治疗后两组患者慢阻肺的综合评估均明显好转(

0.05)，观察组的效果好于对照组(

＝2.066，

0.05)；观察组mMRC和CAT评分均低于对照组(

0.01)；观察组FEV

和FEV

%均高于对照组(

0.05)；观察组SGRQ评分低于对照组，6 MWD多于对照组(

0.01)；观察组CD3

＋

，CD4

＋

，CD4

＋

/CD8

＋

水平均高于对照组，CD8

＋

水平低于对照组(

0.05)；观察组hs-CRP，IL-6，IL-8和TNF-

水平均低于对照组(

0.01)。

结论：

中医综合优化康复措施治疗稳定期慢阻肺患者，能抑制炎性因子，提高免疫功能，可减轻临床症状，改善肺功能，提高患者运动耐力和生活质量，促进了肺的康复。

Abstract

Objective:

To discuss the clinical efficacy of comprehensive optimization of rehabilitation measures of traditional Chinese medicine(TCM) on elderly patients with COPD at stable period

in order to study its effect on immune function and inflammatory factors.

Method:

One hundred and forty-four patients were randomly divided into control group and observation group by random number table. Patients in control group got ipratropium bromide

40-80 μg/time

2-4 times/days

salmeterol roticasone powder

1 suction/time

2 times/days

as well as comprehensive western medical treatment measures of healthcare education

oxygen therapy and respiratory muscle exercise. In addition to the basic therapy of ipratropium bromide and salmeterol roticasone powder

patients in observation group was added with syndrome differentiation therapy of TCM

foot bath with TCM and respiratory function exercise with TCM. The course of treatment was 6 months

and 6-month follow-up were recorded. Comprehensive assessment of COPD was recorded. Before and after treatment

respiratory questionnaire (mMRC)

self-assessment test for patients with chronic obstructive pulmonary disease (CAT)

forced expiratory volume in the first second (FEV

)

FEV

St George's respiratory questionnaire (SGRQ)

6-minute walking distance (6 MWD) were scored. And levels of CD3

CD4

CD8

CD4

/CD8

interleukin-6 (IL-6)

interleukin-8 (IL-8)

tumor necrosis factor-alpha (TNF-alpha) and hypersensitive C-reactive protein (hs-CRP) were detected.

Result:

Comprehensive assessment of COPD in the two groups were better than those before treatment (

0.05)

and that in observation group was better than that in control group (

=2.066

0.05). And scores of mMRC

CAT

SGRQ

hs-CRP

IL-6

IL-8 and TNF-

were lower than those in control group (

0.01)

and level of CD8

was lower than that in control group (

0.05). And levels FEV

and FEV

% were higher than those in control group (

0.05)

and levels of CD3

CD4

/CD8

and 6-minute walking distance were more than those in control group (

0.01).

Conclusion:

Comprehensive optimization of rehabilitation measures in TCM can inhibit inflammatory factors

improve immune function

alleviate clinical symptoms

improve lung function

improve exercise endurance and quality of life of patients

and promote the lung rehabilitation.

关键词

慢性阻塞性肺疾病稳定期玉屏风颗粒百令胶囊慢支固本颗粒百合固金丸免疫功能炎症因子

Keywords

chronic obstructive pulmonary diseasestable phaseYupingfeng granuleBailing capsuleSlow-branching Guben granuleLily Gujin pillsimmune functioninflammatory factors

references

王靓雅，刘冰，祖权，等．补肺健脾益肾方治疗稳定期慢性阻塞性肺疾病营养状况和对免疫功能的影响[J]．中国实验方剂学杂志，2017，23(22)：182-187．

中华医学会呼吸病学分会慢性阻塞性肺疾病学组．慢性阻塞性肺疾病诊治指南(2013年修订版)[J]．中华结核和呼吸杂志，2013，36(4)：255-264．

张善芳，钱叶长，申燕华，等．稳定期慢性阻塞性肺疾病的中西医治疗进展[J]．医学综述，2018，24(24)：4943-4947．

黄少君，傅汝梅．培土生金方对慢性阻塞性肺疾病稳定期患者气道重塑机制的观察[J]．中国实验方剂学杂志，2018，24(1)：174-179．

范良，孔壮．中医综合疗法对慢性阻塞性肺疾病稳定期患者肺康复的疗效研究[J]．中国中医基础医学杂志，2014，20(10)：1425-1426．

程怡，范良，黄琼莲，等．中药足浴配合呼吸功能锻炼操在COPD缓解期康复治疗中的应用[J]．中国中医急症，2015，24(6)：1126-1128．

程怡，范良，黄琼莲，等．呼吸功能锻炼操配合傅氏益肺健脾汤对慢性阻塞性肺疾病患者胃肠功能及生活质量的影响[J]．河南中医，2018，38(9)：1406-1409．

中华中医药学会内科分会肺系病专业委员会．慢性阻塞性肺疾病中医诊疗指南(2011版)[J]．中医杂志，2012，53(1)：80-84．

Antuni J D, Barnes P J. Evaluation of individuals at risk for COPD: beyond the scope of the global initiative for chronic obstructive lung disease [J].Chronic Obstr Pulm Dis, 2016, 3(3): 653-667.

赵云峰，姜艳平，程改存，等．圣乔治呼吸问卷和慢性阻塞性肺疾病评估测试问卷评价慢性阻塞性肺疾病稳定期患者健康相关生活质量的比较[J]．上海医学，2013，36(1)：47-51．

张小娥，张彩莲．慢性阻塞性肺疾病流行病学及疾病经济负担研究进展[J]．中国慢性病预防与控制，2017，25(6)：472-476．

WANG C, XU J, YANG L. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pul-monary Health [CPH] study): a national cross-sectional study [J].Lancet, 2018, 391 (10131): 1706-1717.

朱惠莉．老年慢性阻塞性肺疾病的慢病管理现状及进展[J]．老年医学与保健，2018，24(3)：219-222．

廖丽君，张鹏飞，陈斯宁．中医特色疗法治疗COPD稳定期研究进展[J]．辽宁中医药大学学报，2017，19(7)：175-178．

庞天祥，张弘．玉屏风散治疗慢性阻塞性肺疾病的Meta分析[J]．山西中医学院学报，2016，17(4)：14-15，65．

杜强，崔进，蔡健康，等．百令胶囊对中重度慢性阻塞性肺病患者肺功能、气道炎症以及氧化应激的影响[J]．南京医科大学学报：自然科学版，2015，35(1)：58-61．

范良，卢保强，郑肇良，等．中药沐足治疗慢性阻塞性肺疾病稳定期的临床研究[J]．中国中医基础医学杂志，2016，22(8)：1074-1076．

王晓娟，方向阳．慢性阻塞性肺疾病全球倡议2019：慢性阻塞性肺疾病诊断、治疗与预防全球策略解读[J]．中国全科医学，2019，33(3)：1-9．

谭博，杜永成，张爱珍，等．发掘慢性阻塞性肺疾病临床终点预测性替代指标纵向研究成果及意义[J]．中国实用内科杂志，2016，36(8)：698-700．

杨凌婧．稳定期中重度慢阻肺患者血清IL-6，IL-8，TNF-α，hs-CRP与肺功能的相关性研究[J]．临床肺科杂志，2016，21(3)：481-484．

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Related Institution

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