Modern Pharmacological Effect and Mechanism of Shengmai San

Zhan-hong CAO; Jian-heng PAN; Na LI; Xiao-bo QU; Dong HAN

doi:10.13422/j.cnki.syfjx.20192208

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Modern Pharmacological Effect and Mechanism of Shengmai San

Review | 更新时间：2021-02-09

- Modern Pharmacological Effect and Mechanism of Shengmai San
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 22, Pages: 212-218(2019)
- 作者机构：
  
  长春中医药大学，长春　 130117
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192208
  CLC： R2-0; R22; R285.5; R284
- Published：20 November 2019，
  
  Published Online：02 August 2019，
  
  Received：19 April 2019，
- 稿件说明：
扫描看全文
Zhan-hong CAO, Jian-heng PAN, Na LI, et al. Modern Pharmacological Effect and Mechanism of Shengmai San. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):212-218(2019)
DOI：

Zhan-hong CAO, Jian-heng PAN, Na LI, et al. Modern Pharmacological Effect and Mechanism of Shengmai San. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):212-218(2019) DOI： 10.13422/j.cnki.syfjx.20192208.

摘要

生脉散始见于金代医家张元素的《医学启源》，由人参片、麦冬、五味子组成，方中人参为君药，大补元气，益肺生津止渴；臣药麦冬甘寒养阴、清热生津、且润肺止咳，人参片、麦冬相伍，其益气之功显著。佐以五味子之酸收、敛阴止汗，配人参则补固正气，伍麦冬则收敛阴津，是治疗气阴两虚的经典方。随着现代医家的深入研究，发现生脉散不仅对心血管疾病、中枢神经系统疾病、内分泌系统疾病有显著的治疗效果，而且对消化系统疾病、免疫系统与造血系统、休克的治疗中也有着良好的效果。由于我国人口老龄化、生活饮食不规律等问题日益严重，导致心血管疾病、老年痴呆、脑梗塞、糖尿病、肝功能障碍等疾病的发病率一直居高不下且有年轻化趋势，严重威胁着人类健康。因此，笔者在查阅大量国内文献的基础上，分别阐述生脉散及其加减方对以上疾病的治疗作用及作用机制，旨在揭示该方对以上疾病作用靶点及作用机制，为更好的治疗以上疾病及拓宽该方的临床应用提供理论依据。此外，为其他经典名方的研究提供参考思路。

Abstract

Shengmai San was first recorded in

Medical Origin and Insights

a medical book written by ZHANG Yuan-su. Shengmai San composed of Ginseng Radix et Rhizoma

Ophiopogonis Radix and Schiandrae Chinensisin Fructus. Ginseng Radix et Rhizoma as the monarch drug in the prescription has effects in invigorating vigour potently

and promoting production of body fluid to quench thirst. Ophiopogonis Radix as a sweet-cold minister drug has effects in nourishing yin

clearing heat and generating fluid and moistening lung to stop cough in the prescription. Both medicines are combined to have a good effect in replenishing Qi. Schiandrae Chinensisin Fructus is an adjuvant medicine

with effects in acid astringency

retaining Yin with astringent and hidroschesis. Ginseng Radix et Rhizoma has effects in strengthening the healthy energy

and Ophiopogonis Radix has a effect in retaining yin with astringent. It is a classic prescription for treating deficiency of Qi and Yin. With the in-depth research of modern medical experts

it is found that Shengmai San not only has a significant therapeutic effect on cardiovascular diseases

central nervous system diseases and endocrine system diseases

but also a good effect on digestive system diseases

immune system and hematopoietic system diseases and shock. As China's aging population

irregular diet and other problems become increasingly serious

the incidences of cardiovascular diseases

senile dementia

cerebral infarction

diabetes

liver dysfunction and other diseases have become higher and younger

which is a serious threat to human health. Therefore

by consulting a large number of domestic literatures

the authors respectively elaborated the therapeutic effect and mechanism of Shengmai San and its modified prescriptions on the above diseases

with the aim to reveal the target and mechanism of this prescription on the above diseases

provide theoretical basis for better treatment of the above diseases and promote the clinical application of this prescription. In addition

it provides reference ideas for the research of other classical famous formula.

关键词

生脉散心肌缺血脑缺血糖尿病保肝抗休克

Keywords

Shengmai Sanmyocardial ischemiacerebral ischemiadiabetes mellitusliver protectionanti-shock

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