With the development of economic globalization and the increasingly complex international competition environment， pharmaceutical research and development has become the most powerful weapon for pharmaceutical companies to cope with the uncertainty of the competitive market. From the perspective of the pharmaceutical industry， based on the five-element theory， the article used the thinking of comparative state to carry out analogy research on the five-element theory and entrepreneur type system. Based on the entrepreneur type system and enterprise management system， the article embedded the enterprise senior management team system， and entrepreneurs were included in the system and assigned roles according to their different characteristics. Then through the analysis of the relationship between different entrepreneurs and the research and development （R&D） directors， the article expounded the influence of different types of entrepreneurs on the R&D process. The purpose of this study is to provide different types of entrepreneurs with management solutions for pharmaceutical R&D innovation and internal collaborative management， which is conducive to the analysis of advantages and disadvantages of entrepreneurs based on their own characteristics， and can effectively improve their ability of internal resource integration and independent innovation in drug R&D.