Objective

2

To explore the clinical efficacy of modified Ditantang combined with acupuncture in the treatment of dysphagia after apoplexy （DAS） syndrome of phlegm and blood stasis blocking collaterals.

Method

2

One hundred and eight patients were randomly divided into control group （54 cases） and observation group （54 cases） by number table. Both groups underwent nutritional management，rehabilitation training and acupuncture. Patients in control group additionally took Tongluo Huatan capsules， 3 granules/time， 3 times/day， while patients in observation received modified Ditantang. Both groups had two weeks of treatment. The Kubota's drinking water test， swallowing contrast examination （VFSS）， and standard swallowing function assessment （SSA） were conducted. Swallowing disorder specific quality of life scale （SWAL-QOL） and sputum collateral stasis syndrome were scored before and after treatment. The levels of brain-derived neurotrophic factor （BDNF）， nerve growth factor （NGF） and neuron-specific enolase （NSE） before and after treatment. The occurrence of pneumonia， malnutrition， dehydration and aspiration were then recorded.

Result

2

The clinical effective rate was （47/49） 95.92%in the observation group， higher than （41/50） 82.00% in the control group's （

χ

2

=4.854，

P

<

0.05）. The grade of Kubota's drinking water test in observation group was lower than that in the control group（

Z

=2.211，

P

<

0.05）. VFSS swallowing dysfunction in observation group was lighter than that in control group（Z=1.969，

P

<

0.05）. The scores of Kubota's drinking water test， SSA and phlegm and blood stasis blocking collateral syndrome in the observation group were all lower than those in the control group（

P

<

0.01）， while the VFSS score was higher than that in control group （

P

<

0.01）. The swallowing symptom score， other symptom scores and total SWAL-QOL scores of the observation group were higher than those of the control group（

P

<

0.01）. The levels of BDNF and NGF in the observation group were higher than those in the control group （

P

<

0.01）， but the NSE level was lower than that in the control group（

P

<

0.01）. The complication rate in the observation group was （6/49）12.24%， which was lower than （15/50）30.00% in the control group（

χ

2

=4.668，

P

<

0.05）.

Conclusion

2

On the basis of nutrition management and rehabilitation training， modified Ditantang combined with acupuncture can reduce the risk of dysphagia and aspiration， improve the degree of neurological deficits， improve the quality of life， and reduce complications in treatment of DAS syndrome of phlegm and blood stasis， with significant clinical efficacy.