Clinical Efficacy on Yishen Tongluofang for Treatment of Male Infertility with Deficiency and Stasis of Kidney

Fang ZHANG; Zi-xue SUN; Quan QIU; Peng-chao LI; Xin-yang LI; Pei-pei ZHAO

doi:10.13422/j.cnki.syfjx.20210531

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Clinical Efficacy on Yishen Tongluofang for Treatment of Male Infertility with Deficiency and Stasis of Kidney

Clinic | 更新时间：2021-05-17

- Clinical Efficacy on Yishen Tongluofang for Treatment of Male Infertility with Deficiency and Stasis of Kidney
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 27, Issue 11, Pages: 112-116(2021)
- 作者机构：
  
  河南中医药大学第二临床医学院，郑州 450002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20210531
  CLC： R289;R256;R256.56
- Received：25 November 2020，
  
  Published Online：04 January 2021，
  
  Published：05 June 2021
- 稿件说明：
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张芳,孙自学,邱荃等.益肾通络方治疗少弱精子型男性不育症肾虚瘀阻证的临床疗效[J].中国实验方剂学杂志,2021,27(11):112-116.

ZHANG Fang,SUN Zi-xue,QIU Quan,et al.Clinical Efficacy on Yishen Tongluofang for Treatment of Male Infertility with Deficiency and Stasis of Kidney[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(11):112-116.
张芳,孙自学,邱荃等.益肾通络方治疗少弱精子型男性不育症肾虚瘀阻证的临床疗效[J].中国实验方剂学杂志,2021,27(11):112-116. DOI： 10.13422/j.cnki.syfjx.20210531.

ZHANG Fang,SUN Zi-xue,QIU Quan,et al.Clinical Efficacy on Yishen Tongluofang for Treatment of Male Infertility with Deficiency and Stasis of Kidney[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(11):112-116. DOI： 10.13422/j.cnki.syfjx.20210531.

摘要

目的

观察益肾通络方治疗少弱精子型男性不育症肾虚瘀阻证的临床疗效及对血清性激素和精浆微环境的影响。

方法

将104例患者随机按数字表法分为观察组和对照组各52例。对照组口服复方玄驹胶囊，3粒/次，3次/d。观察组内服益肾通络方，1剂/d。两组疗程均为3个月，并随访3个月。记录6个月内配偶受孕情况；进行治疗前后精液参数检查和肾虚瘀阻证评分；检测治疗前后精浆锌、精浆果糖、精浆弹性蛋白酶、精浆酸性磷酸酶，精浆

葡糖苷酶水平及血清促卵泡生成素（FSH），促黄体生成激素（LH），泌乳素（PRT），睾酮（T）水平。

结果

在6个月观察期间，观察组配偶受孕率为22.00%高于对照组的10.00%，但差异无统计学意义（

=2.678，

0.05）；观察组临床疗效优于对照组（

=2.326，

0.01）；观察组精子浓度、精子活率、精子活力、正常形态精子、直线运动速度均高于对照组（

0.01）；观察组精浆锌、精浆果糖水平均高于对照组（

0.01），肾虚瘀阻证评分低于对照组（

0.01）；观察组血清FSH，LH，PRT水平均低于对照组（

0.01），T水平高于对照组（

0.01）；观察组精浆弹性蛋白酶低于对照组（

0.01），精浆酸性磷酸酶，精浆

葡糖苷酶水平均高于对照组（

0.01）。

结论

益肾通络方用于少弱精子型男性不育症肾虚瘀阻证患者可改善精子参数，调节性激素水平和精浆环境，有提高配偶受孕趋势，临床疗效值得进一步研究。

Abstract

Object

To observe the clinical efficacy of Yishen Tongluofang in treating oligosperm type male infertility with kidney deficiency and blood stasis syndrome and explore its effect on serum sex hormones and seminal plasma microenviro.

Method

One hundred and four patients were randomly divided into observation group and control group with 52 cases each. Patients in control group took compound Xuanju capsules orally， 3 capsules/time， 3 times/day. Patients in observation group took Yishen Tongluofang， 1 dose/day. Treatment courses continued three months and followed up for three months in both groups. The pregnancy situations of spouses within six months were recorded. Examination of semen parameters before and after treatment and score of kidney deficiency and blood stasis syndrome were conducted. The levels of seminal plasma zinc， fructose， elastase， acid phosphatase and

-glucosidase， serum follicle stimulating hormone （FSH）， luteinizing hormone （LH）， prolactin （PRT） and testosterone （T） were detected before and after treatment.

Result

During the observation period of six months， the pregnancy rate of spouses in the observation group was 22.00%， higher than 10.00% in the control group， but the difference was not statistically significant （

=2.678，

0.05）. The clinical efficacy in the observation group was better than that of the control group （

=2.326，

0.01）. Sperm concentration， sperm motility， sperm motility， normal morphological sperm and linear movement speed of the observation group were all superior to those of the control group

（

0.01）. The levels of zinc and fructose in seminal plasma of the observation group were higher than those of the control group （

0.01）， and the score of kidney deficiency and blood stasis syndrome was lower than that of the control group （

0.01）. Serum FSH， LH and PRT levels in the observation group were lower than those in the control group （

0.01）， and the T level was higher than that in the control group （

0.01）. The seminal plasma elastase of the observation group was lower than that of the control group， while the levels of acid phosphatase and

-glucosidase were higher than those of the control group （

0.01）.

Conclusion

Yishen Tongluofang can significantly improve sperm parameters， regulate the level of sex hormones and seminal plasma environment in patients with oligosperm type male infertility， and improve the tendency of spouse pregnancy. Its clinical efficacy is better，so it is worthy of further research and application.

关键词

Keywords

references

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