Effect of Modified Shengmaiyin on Children with Acute Lymphocyte Leukemia of Deficiency of Both Qi and Blood

Na AN; Gu-ying ZHANG; Yi-le ZHAO; Li-hong CAO; Jing WANG; Xue ZHANG; Yu-li LIANG

doi:10.13422/j.cnki.syfjx.20210631

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Effect of Modified Shengmaiyin on Children with Acute Lymphocyte Leukemia of Deficiency of Both Qi and Blood

更新时间：2021-09-07

- Effect of Modified Shengmaiyin on Children with Acute Lymphocyte Leukemia of Deficiency of Both Qi and Blood
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 27, Issue 19, Pages: 126-131(2021)
- 作者机构：
  
  1.河北省儿童医院，石家庄 050031
  2.河北省中医院，石家庄 050013
  3.河北医科大学第一医院，石家庄 050030
  4.河北工程大学附属医院，河北邯郸 056002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20210631
  CLC： R289;R733.7;R272;R273
- Received：04 January 2021，
  
  Published Online：03 February 2021，
  
  Published：05 October 2021
- 稿件说明：
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安娜,张古英,赵宜乐等.加味生脉饮辅助化疗对气血两虚证急性淋巴细胞白血病患儿的影响[J].中国实验方剂学杂志,2021,27(19):126-131.

AN Na,ZHANG Gu-ying,ZHAO Yi-le,et al.Effect of Modified Shengmaiyin on Children with Acute Lymphocyte Leukemia of Deficiency of Both Qi and Blood[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(19):126-131.
安娜,张古英,赵宜乐等.加味生脉饮辅助化疗对气血两虚证急性淋巴细胞白血病患儿的影响[J].中国实验方剂学杂志,2021,27(19):126-131. DOI： 10.13422/j.cnki.syfjx.20210631.

AN Na,ZHANG Gu-ying,ZHAO Yi-le,et al.Effect of Modified Shengmaiyin on Children with Acute Lymphocyte Leukemia of Deficiency of Both Qi and Blood[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(19):126-131. DOI： 10.13422/j.cnki.syfjx.20210631.

摘要

目的

观察加味生脉饮辅助化疗对气血两虚证急性淋巴细胞白血病（ALL）患儿营养情况和免疫功能的调节效果。

方法

将100例ALL化疗患儿按随机数字表法分为观察组和对照组各50例。两组患儿均给予长春新碱（泼尼松）+柔红霉素+左旋门冬酰胺酶（VDLD）方案进行诱导缓解治疗和环磷酰胺+阿糖胞苷+6-巯基嘌呤（CAM）方案进行早期强化治疗。对照组口服生脉饮，10 mL/次，3次/d。观察组口服加味生脉饮，1剂/d。两组疗程均为3个月。进行治疗前后微型营养评定（MNA），并检测治疗前后血清总蛋白（TB），白蛋白（ALB），前白蛋白（PAB），T细胞CD4

，CD8

，免疫球蛋白G（IgG），免疫球蛋白M（IgM），免疫球蛋白A（IgA）水平，计算CD4

/CD8

；进行治疗前后中医证候评分，Piper疲乏修订量表（PFS-R）和儿童生活质量普适性核心量表（PedsQL）评分；评价治疗前后白细胞（WBC），红细胞（RBC），血红蛋白（Hb）和血小板（PLT）变化。

结果

治疗后观察组营养状况高于对照组（

＝2.018，

0.05）；观察组疲乏程度低于对照组（

＝2.029，

0.05）；观察组MNA评分高于对照组（

0.01），PFS-R和气血两虚证评分均低于对照组（

0.01）；观察组TB，ALB，PAB，CD4

水平和CD4

/CD8

均高于对照组（

0.01），CD8

低于对照组（

0.01）；观察组IgM和IgA水平均高于对照组（

0.01）；观察组RBC，Hb和PLT水平均高于对照组（

0.01）。

结论

加味生脉饮内服辅助用于ALL化疗患儿，可提高营养状况，改善免疫功能，促进免疫平衡，减轻临床症状，促进造血系统的恢复，提高生活质量。

Abstract

Objective

To observe the regulatory effect of modified Shengmaiyin adjuvant chemotherapy on the nutritional status and immune function of children with acute lymphocyte （ALL）.

Method

One hundred children with ALL chemotherapy were randomly divided into observation group and control group. Both groups were given VDLD regimen as the induction therapy and CAM regimen as the early therapy. Control group was given Shengmaiyin orally， 10 mL/time， 3 times/day. Observation group was given modified Shengmaiyin orally， 1 does/day. The course of treatment for both groups was 3 months. Micro-nutrition assessment （MNA） was carried out before and after treatment， and serum total protein （TB）， albumin （ALB）， prealbumin （PAB）， T cell CD4

， CD8

， immunoglobulin G （IgG）， IgM， IgA levels were detected before and after treatment. The ratio of CD4

/CD8

was calculated. The traditional Chinese medicine （TCM） syndrome before and after treatment and the piper fatigue scale （PFS-R） and universal core scale of children's quality of life （PedsQL） were scored. The changes of white blood cells （WBC）， red blood cells （RBC）， hemoglobin （Hb） and platelets （PLT） were evaluated before and after treatment.

Result

The nutritional status of the observation group was better than that of the control group after treatment （

=2.018，

0.05）. The observed fatigue was lighter than that of the control group （

=2.029，

0.05）. The MNA score of the observation group was higher than that of the control group （

0.01）. The scores of PFS-R and deficiency of both Qi and blood were lower than those of the control group （

0.01）. The CD4

levels and CD4

/CD8

levels of TB， ALB and PAB in the observation group were higher than those in the control group （

0.01）， while the CD8

was lower than the control group （

0.01）. The IgM and IgA levels in the observation group were higher than those in the control group （

0.01）. The RBC， Hb and PLT levels of the observation group were higher than those of the control group （

0.01）.

Conclusion

Modified Shengmaiyin can be used as adjuvant therapy for children with ALL chemotherapy by improving nutritional status， immune function and immune balance， reducing clinical symptoms， promoting the recovery of hematopoietic system and improving the quality of life.

关键词

Keywords

references

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