Discussion on Connotation of "Essence Generating Marrow " Based on Intervention of Guilu Erxian Gum in Perivascular Space of Alzheimer's Disease Patients

Jun-jie MA; Chun-xiang ZHOU; Xiao-long WANG

doi:10.13422/j.cnki.syfjx.20211091

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Discussion on Connotation of "Essence Generating Marrow " Based on Intervention of Guilu Erxian Gum in Perivascular Space of Alzheimer's Disease Patients

Clinic | 更新时间：2021-05-17

- Discussion on Connotation of "Essence Generating Marrow " Based on Intervention of Guilu Erxian Gum in Perivascular Space of Alzheimer's Disease Patients
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 27, Issue 11, Pages: 106-111(2021)
- 作者机构：
  
  1.南京中医药大学中医学院，中西医结合学院，南京 210046
  2.江苏省沭阳县中医院，陈亦人学术传承工作室，江苏沭阳 223600
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20211091
  CLC： R22;R242;R2-031;R287;R277.7
- Received：10 January 2021，
  
  Published Online：25 March 2021，
  
  Published：05 June 2021
- 稿件说明：
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马俊杰,周春祥,王小龙.基于龟鹿二仙胶干预阿尔茨海默病血管周围间隙探讨“精生髓”内涵[J].中国实验方剂学杂志,2021,27(11):106-111.

MA Jun-jie,ZHOU Chun-xiang,WANG Xiao-long.Discussion on Connotation of "Essence Generating Marrow " Based on Intervention of Guilu Erxian Gum in Perivascular Space of Alzheimer's Disease Patients[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(11):106-111.
马俊杰,周春祥,王小龙.基于龟鹿二仙胶干预阿尔茨海默病血管周围间隙探讨“精生髓”内涵[J].中国实验方剂学杂志,2021,27(11):106-111. DOI： 10.13422/j.cnki.syfjx.20211091.

MA Jun-jie,ZHOU Chun-xiang,WANG Xiao-long.Discussion on Connotation of "Essence Generating Marrow " Based on Intervention of Guilu Erxian Gum in Perivascular Space of Alzheimer's Disease Patients[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(11):106-111. DOI： 10.13422/j.cnki.syfjx.20211091.

摘要

目的

从调节血管周围间隙（PVS）角度研究龟鹿二仙胶干预阿尔茨海默病（AD）的效应机制，进而探索“精生髓”的科学内涵。

方法

80 例西医诊断为AD，中医诊断为肾虚髓空证的患者随机分成两组，每组 40 例。两组患者均口服胆碱酯酶抑制剂盐酸多奈哌齐片，每次1片（5 mg），于晚上睡前服用，在此基础上对照组给予安慰剂，治疗组采用龟鹿二仙胶治疗，疗程为 60 d，两组治疗前（第0天），治疗第31天及第61天分别采用简易智力状态量表（MMSE），韦氏成人记忆表（WMS）和生活功能量表（ADL）进行评分，并进行头颅核磁共振成像（MRI）检查，计数中脑、基底节区、岛叶深部白质、半卵圆中心PVS的数目总和并测量其直径，此外，第61天根据MMSE评分评价疗效。

结果

两组各项指标在第31天时差异无统计学意义；第61天时，与各组第0天相比，两组MMSE评分，WMS评分升高，ADL评分下降，差异有统计学意义（

0.01），两组间上述3项指标及临床有效率比较，差异有统计学意义（

0.05，

0.01），此外，两组患者PVS数目与治疗前及组间比较差异无统计学意义，两组患者PVS直径与治疗前及组间比较差异有统计学意义（

0.01）。

结论

龟鹿二仙胶治疗AD疗效确切，且具有改善患者PVS直径的作用，此可能与该方参与“精生髓”的机制有关。

Abstract

Objective

To study the effect mechanism of Guilu Erxian gum on Alzheimer's disease （AD） from the perspective of regulating perivascular space （PVS），and to explore the scientific connotation of "essence generating marrow".

Method

The 80 patients with AD diagnosed by western medicine and kidney deficiency and marrow empty syndrome diagnosed by traditional Chinese medicine were randomly divided into two groups，with 40 cases in each group. Both groups of patients were orally administered with cholinesterase inhibitor Alison，one tablet （5 mg） each time before sleep at night. On this basis，the control group additionally received placebo，while the treatment group was additionally treated with Guilu Erxian gum for 60 days. The Mini-Mental State Examination scale （MMSE）， Wechsler Memory Scale and Activity of Daily Living Scale （ADL） were used before treatment （0 d），as well as 31 d and 61 d after treatment. The number and diameter of PVS in midbrain，basal ganglia，deep insular white matter and semiovale center were counted and their diameters were measured with use of nuclear magnetic resonance imaging （MRI） for head. In addition，the curative effect was evaluated according to MMSE scores on 61 d.

Result

There was no significant difference between the two groups 31 d. On 61 d，MMSE and WMS scores increased，while ADL scores decreased as compared with the conditions on 0 d（

0.01），and there were significant differences in the three indexes and clinical effective rate between two groups （

0.05，

0.01） . In addition，there was no significant difference in the number of PVS as compared with the number before treatment and in the comparison between the two groups after treatment，but there was a significant difference in the diameter of PVS（

0.01）.

Conclusion

Guilu Erxian gum is effective in the treatment of AD，and it can improve the PVS diameter in patients，which may be related to the mechanism of "essence generating marrow ".

关键词

Keywords

references

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