Objective

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To explore the therapeutic principles and medication regularity of Chinese medicine for the treatment of urolithiasis based on data mining and literature research.

Method

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Chinese National Knowledge Infrastructure（CNKI） was searched for the clinical research papers on Chinese medicinal compounds for the treatment of urolithiasis published from database inception to November 10，2020. Therapeutic methods and Chinese medicinal compounds were extracted from the included papers，and the frequencies of therapeutic methods and the drugs in the Chinese medicinal compounds，as well as the efficacies were analyzed. The medication regularity of high-frequency drugs was explored by association rule analysis and cluster analysis.

Result

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A total of 247 papers and 247 Chinese medicinal compounds were included，and 209 drugs were involved. Those with high frequencies included Lysimachiae Herba，Galli Gigerii Endothelium Corneum，Lygodii Spora，Achyranthis Bidentatae Radix，Pyrrosiae Folium，Plantaginis Semen，and Talcum. The drugs with the highest frequency were effective in promoting urination，draining dampness，and activating blood to resolve stasis，followed by those in tonifying deficiency，regulating Qi，and purgation. Galli Gigerii Endothelium Corneum，Clematidis Radix et Rhizoma，and Succinum were used as specialized drugs targeting the syndrome. Association rule analysis showed that Lysimachiae Herba，Galli Gigerii Endothelium Corneum，and Lygodii Spora were commonly used in pairwise or ternary combination，followed by the pairwise combinations of Lysimachiae Herba with Achyranthis Bidentatae Radix，Pyrrosiae Folium，and Plantaginis Semen. High-frequency drugs were clustered into four categories by clustering analysis. Thirty-one therapeutic principles were employed in the 247 Chinese medicinal compounds. The ones with the highest frequency were clearing heat and eliminating dampness，resolving stasis and promoting urination，and tonifying kidney and replenishing qi.

Conclusion

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For the treatment of urolithiasis，promoting urination and draining dampness is the core therapeutic principle，and activating blood to resolve stasis is the important therapeutic principle，while tonifying is the potential therapeutic principle. The medication for urolithiasis is featured by specialized drugs targeting the syndrome.