Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous

Hao HE; Hui-qin YANG; Rong ZOU

doi:10.13422/j.cnki.syfjx.20212193

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous

更新时间：2021-10-14

- Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 27, Issue 21, Pages: 138-143(2021)
- 作者机构：
  
  武汉市第一医院，武汉 430000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20212193
  CLC： R22;R242;R2-031;R287;R593.24
- Received：10 May 2021，
  
  Published Online：22 September 2021，
  
  Published：05 November 2021
- 稿件说明：
移动端阅览
何浩,杨惠琴,邹荣.青蒿扶正解毒汤治疗系统性红斑狼疮临床疗效观察[J].中国实验方剂学杂志,2021,27(21):138-143.

HE Hao,YANG Hui-qin,ZOU Rong.Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(21):138-143.
何浩,杨惠琴,邹荣.青蒿扶正解毒汤治疗系统性红斑狼疮临床疗效观察[J].中国实验方剂学杂志,2021,27(21):138-143. DOI： 10.13422/j.cnki.syfjx.20212193.

HE Hao,YANG Hui-qin,ZOU Rong.Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(21):138-143. DOI： 10.13422/j.cnki.syfjx.20212193.

摘要

目的

研究青蒿扶正解毒汤治疗系统性红斑狼疮（SLE）的临床疗效。

方法

选取2019年12月至2020年10月武汉市第一医院风湿免疫科收治的109例SLE患者为研究对象，采用随机数字表法分为观察组（55例）和对照组（54例），其中观察组脱落2例，合计53例，对照组脱落1例，合计53例，对照组给予泼尼松片和硫唑嘌呤治疗，观察组患者在对照组基础上加用青蒿扶正解毒汤治疗，比较两组临床疗效、中医证候积分、中医证候疗效、免疫球蛋白（Ig）G，IgA，IgM及补体C3，C4变化情况，统计两组患者治疗后抗核抗体（ANA）及抗双链脱氧核糖核酸抗体（ds-DNA）转阴情况。

结果

观察组临床治疗总有效率（92.45%）明显高于对照组总有效率（73.58%），差异有统计学意义（

=6.692，

0.05）。治疗前，两组IgG，IgA，IgM及补体C3，C4水平，血清ANA，ds-DNA滴度比较差异无统计学意义；治疗后，两组IgG，IgA，IgM水平，血清ANA，ds-DNA滴度与治疗前比较明显下降，补体C3，C4水平明显上升（

0.05），与对照组比较，观察组患者IgG，IgA，IgM水平，血清ANA，ds-DNA滴度明显降低，补体C3，C4水平明显上升（

0.05），观察组ANA，ds-DNA转阴率明显高于对照组（

=8.040，

0.05）。与治疗前比较，两组中医证候积分均明显下降，且对照组中医证候积分明显高于观察组（

0.05）；观察组中医证候疗效总有效率（94.34%）明显高于对照组中医证候治疗总有效率（50.94%），差异有统计学意义（

=25.112，

0.05）。

结论

青蒿扶正解毒汤治疗SLE疗效确切，具有一定临床应用价值。

Abstract

Objective

To study the clinical effect of Qinghao Fuzheng Jiedu decoction on systemic lupus erythematous （SLE）.

Method

A total of 109 SLE patients admitted to the Rheumatology and Immunology Department of Wuhan No. 1 Hospital from December 2019 to October 2020 were selected and divided into an observation group （55 cases） and a control group （54 cases） using the random number table. Two cases in the observation group dropped out， leaving a total sample of 53， and one case in the control group dropped out， with 53 cases finally included. Patients in the control group were treated with prednisone tablet and azathioprine. On this basis， those in the observation group further received Qinghao Fuzheng Jiedu decoction. The clinical efficacy， traditional Chinese medicine （TCM） syndrome score， TCM syndrome efficacy， immunoglobulin （Ig） G， IgA， IgM， and complements C3 and C4 of the two groups were compared. The conversion of positive antinuclear antibody （ANA） and anti-double-stranded deoxyribonucleic acid antibody （DS-DNA） titers to negative in two groups after treatment was analyzed.

Result

The total clinical efficacy rate of the observation group was significantly higher than that of control group （92.45% vs 73.58%，

=6.692，

0.05）. Before treatment， there were no significant differences in IgG， IgA， IgM， complements C3 and C4， and serum ANA and ds-DNA titers between two groups. After treatment， the levels of IgG， IgA， and IgM and serum ANA and ds-DNA titers in both groups obviously declined， whereas the levels of complements C3 and C4 rose （

0.05）. Besides， the levels of IgG， IgA， and IgM and serum ANA and ds-DNA titers in the observation group were lower than those in the control group， while the levels of complements C3 and C4 were higher （

0.05）. The negative rates of ANA and ds-DNA in observation group were significantly higher than those in control group （

=8.040，

0.05）. TCM syndrome scores were decreased in both groups after treatment （

0.05）， and the score in observation group was lower than that in control group （

0.05）. In terms of TCM syndrome efficacy， the total effective rate of observation group was significantly increased as compared with that of the control group （94.34% vs 50.94%，

=25.112，

0.05）.

Conclusion

Qinghao Fuzheng Jiedu decoction is effective in treating SLE and has a certain clinical application value.

关键词

Keywords

references

MCKEON K P ， JIANG S H . Treatment of systemic lupus erythematosus ［J］. Australian Prescriber ， 2020 ， 43 （ 3 ）： 85 - 90 .

刘婷，胥魏，陈海凤，等 . 住院死亡系统性红斑狼疮91例患者临床特点分析［J］. 中华风湿病学杂志， 2019 ， 23 （ 8 ）： 530 - 535 .

胡素侠 . 36例系统性红斑狼疮患者体液免疫功能测定的临床研究［J］. 国际检验医学杂志， 2017 ， 38 （ 10 ）： 1419 - 1421 .

MORIMOTO C ， REINHERZ E L ， DISTASO J A ， et al . Relationship between systemic lupus erythematosus T cell subsets，anti-T cell antibodies，and T cell functions ［J］. J Clin Invest ， 2018 ， 73 （ 3 ）： 689 - 700 .

刘莹，陈龙 . 青蒿汤方联合泼尼松片治疗系统性红斑狼疮疗效观察［J］. 湖北中医杂志， 2018 ， 40 （ 5 ）： 26 - 28 .

中国系统性红斑狼疮研究协作组专家组．糖皮质激素在系统性红斑狼疮患者合理应用的专家共识［J］．中华内科杂志， 2014 ， 53 （ 6 ）： 502 - 504 .

国家中医药管理局 . 中药新药临床研究指导原则［M］. 北京：中国医药科技出版社， 2002 ： 112 - 115 .

田园，杨月 . 补肾活血法治疗系统性红斑狼疮临床疗效和安全性的Meta分析［J］. 辽宁中医杂志， 2019 ， 10 （ 2 ）： 32 - 35 .

何晶晶，马隽，任柄睿，等 . mTOR信号通路在系统性红斑狼疮发病机制中的研究进展［J］. 中国免疫学杂志， 2019 ， 35 （ 22 ）： 2801 - 2805 .

WANG R ， WANG C F ， QIN H M ， et al . Association between polymorphisms in the promoter region of miR cluster and systemic lupus erythematosus in a Chinese population ［J］. J J Cell Mol Med ， 2018 ， 10 （ 2 ）： 21 - 23 .

梁一晨，姚洋，张芮君，等 . 外周血效应型滤泡辅助性T细胞和滤泡辅助性T细胞亚型在系统性红斑狼疮发病机制中的作用［J］. 中华医学杂志， 2019 ， 99 （ 3 ）： 164 - 168 .

PAN L ， LU M P ， WANG J H ， et al . Immunological pathogenesis and treatment of systemic lupus erythematosus ［J］. World J Pediatr ， 2019 ， 10 （ 2 ）： 14 - 16 .

CROW M K . Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus ［J］. J Clin Invest ， 2018 ， 76 （ 2 ）： 807 - 815 .

MAGRO R . Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus ［J］. Ther Adv Musculoskelet Dis ， 2019 ， 11 （ 2 ）： 412 - 414 .

杨梓，范永升 . 从"邪伏少阴"探讨系统性红斑狼疮的发病机制与临床辨治［J］. 中华中医药杂志， 2019 ， 34 （ 5 ）： 371 - 373 .

蔡悦，薛斌 . 基于中药传承辅助平台研究系统性红斑狼疮的用药规律［J］. 华西药学杂志， 2019 ， 34 （ 2 ）： 192 - 197 .

白琳，赵君 . 青蒿鳖甲汤对阴虚内热型系统性红斑狼疮患者血清免疫球蛋白和补体C3，C4的影响［J］. 实用临床医药杂志， 2019 ， 23 （ 19 ）： 53 - 56 .

HONDA M ， SAKANE T ， STEINBERG A D ， et al . Studies of immune functions of patients with systemic lupus erythematosus：antibodies to desialized，rather than intact，T cells preferentially bind to and eliminate suppressor effector T cells ［J］. J Clin Invest ， 2018 ， 69 （ 4 ）： 940 - 949 .

常杰，李忱，张文 . 青蒿、青蒿素及其衍生物治疗系统性红斑狼疮研究现状［J］. 中国中西医结合杂志， 2019 ， 39 （ 3 ）： 377 - 380 .

汪金华 . 狼疮解毒汤联合针刺治疗系统性红斑狼疮疗效及安全性研究［J］. 四川中医， 2018 ， 36 （ 9 ）： 186 - 188 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Efficacy of Ditantang on Pediatric Epilepsy with Phlegm and Stasis-type Tonic-clonic Seizure and Its Effect on Immunoglobulin, Peripheral Blood Th17 Cells and Relevant Factors

Clinical Efficacy of Zhuyuwan in Treatment of Hyperlipidemia with Syndrome of Phlegm Turbidity and Obstruction

Clinical Randomized Controlled Trial of Traditional Chinese Medicine Compound Shenlong Decoction Granules in Treatment of Idiopathic Pulmonary Fibrosis

Clinical Efficacy of Jinwei Pingchuan Decoction in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm-heat Obstruction in Lung Syndrome

Clinical Efficacy of Fuyuan Tongluo Prescription in Prevention and Treatment of Restenosis with Collateral Obstruction Syndrome After Interventional Operation of Lower Limb Arteriosclerosis Obliterans

Related Author

Xiao-li HUANG

Yi-qin LONG

Bin YU

YANG Lele

LUO Danmei

CHEN Jiao

ZHANG Xiaobo

SONG Wei

Related Institution

The First Affiliated Hospital of Guangzhou University of Chinese Medicine

Liuzhou Maternity and Child Healthcare Hospital

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

Chengdu University of TCM

Liaoning University of Traditional Chinese Medicine（TCM）

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰