Regulation of Mitochondrial Quality Control in Treatment of Diabetic Kidney Disease by Traditional Chinese Medicine： A Review

ZHANG Mengting; LI Yuying; ZHANG Lan

doi:10.13422/j.cnki.syfjx.202201723

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Regulation of Mitochondrial Quality Control in Treatment of Diabetic Kidney Disease by Traditional Chinese Medicine： A Review

更新时间：2023-01-17

- Regulation of Mitochondrial Quality Control in Treatment of Diabetic Kidney Disease by Traditional Chinese Medicine： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 4, Pages: 236-245(2023)
- 作者机构：
  
  1.辽宁中医药大学，沈阳 110847
  2.辽宁中医药大学附属医院，沈阳 110847
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.202201723
  CLC： R22;R242;R2-031;R285.5
- Published：20 February 2023，
  
  Published Online：20 July 2022，
  
  Received：19 February 2022，
- 稿件说明：
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张梦婷,李昱颖,张兰.中医药调控线粒体质量控制治疗糖尿病肾病研究进展[J].中国实验方剂学杂志,2023,29(04):236-245.

ZHANG Mengting,LI Yuying,ZHANG Lan.Regulation of Mitochondrial Quality Control in Treatment of Diabetic Kidney Disease by Traditional Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(04):236-245.
张梦婷,李昱颖,张兰.中医药调控线粒体质量控制治疗糖尿病肾病研究进展[J].中国实验方剂学杂志,2023,29(04):236-245. DOI： 10.13422/j.cnki.syfjx.202201723.

ZHANG Mengting,LI Yuying,ZHANG Lan.Regulation of Mitochondrial Quality Control in Treatment of Diabetic Kidney Disease by Traditional Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(04):236-245. DOI： 10.13422/j.cnki.syfjx.202201723.

摘要

糖尿病肾病典型表现为早期肾脏高滤过和蛋白尿漏出，随后是进行性肾功能下降、球管系统上皮细胞肥大及间质纤维化，是慢性肾病的主因之一。目前，现代医学缺少较好的治疗手段，主要以控制原发疾病来降低肾脏损伤风险为主，而中医药通过辨证合参，利水消肿以治标、补虚培元以调本，能起到一定治疗和延缓肾病进展的作用，具有综合调理患者体质和不良反应小等优势。肾脏线粒体含量位居脏腑第二，参与水液代谢等生理过程，为人体元阴元阳之本。线粒体是细胞能量生产器，具有细胞呼吸、活性氧生成和氧化磷酸化产生三磷酸腺苷的功能。线粒体质量控制是维持线粒体动态平衡的有效方式，其失调与糖尿病肾病的发生发展密切相关，包括线粒体氧化应激、线粒体自噬、线粒体动力学改变及钙调节异常等，一般认为机体代谢异常下的线粒体结构破坏是其成因。近年来，中医药因在糖尿病肾病治疗中标本兼治、多靶点协同作用的独特优势使其疗效机制研究受到国内外学者关注，但具体作用机制并不明朗。多项研究显示线粒体可能是中医药治疗糖尿病肾病的作用靶点之一，目前有关中医药通过干预线粒体质量控制治疗糖尿病肾病综述尚且缺乏，因此拟对近10年中医药通过调节线粒体质量控制治疗糖尿病肾病进行总结梳理，以期为中医药治疗糖尿病肾病提供新的方向。

Abstract

Diabetic kidney disease （DKD） is characterized by the hyperfiltration and albuminuria in the early phase which are followed by progressive renal function decline， renal tubular epithelial cell hypertrophy， and tubulointerstitial fibrosis. Thus， it is one of the leading causes of chronic kidney diseases. The currently available therapies mainly aim to control the primary diseases and reduce the risk of kidney injury. Based on syndrome differentiation， traditional Chinese medicine （TCM） relieves the symptoms by excreting water and alleviating edema and eliminates the root cause by tonifying deficiency and supplementing the original Qi， thereby showing therapeutic effect and delaying the progression of DKD. It excels in comprehensively regulating the constitution of patients with little side effects. Among the Zang-fu organs， kidney takes the second place in the content of mitochondria which participate in the metabolism of water and fluid and are the foundation of kidney Yin and kidney Yang. Mitochondria are energy producers within a cell， which carry out cellular respiration， produce reactive oxygen species， and generate adenosine triphosphate by oxidative phosphorylation. Mitochondrial quality control （MQC） is an effective way to maintain mitochondrial dynamic balance， whose imbalances， such as mitochondrial oxidative stress， mitophagy， mitochondrial dynamic changes， and abnormal calcium regulation， are related to the occurrence and development of DKD. It is generally believed that the destruction of mitochondrial structure in the case of metabolic disorder is the main cause of the disease. In recent years， TCM has attracted the attention of both Chinese and foreign researchers for the unique advantages of treating both symptoms and root cause at the same time and multi-target synergy in the treatment of DKD. However， the specific mechanism is still unclear. It has been frequently verified that mitochondria may be one of the targets of TCM in the treatment of DKD. At the moment， no review on the treatment of DKD by TCM through the intervention of MQC is available. Therefore， this paper aims to summarize the research on TCM treatment of DKD by regulating MQC in the past 10 years， which is expected to provide a new direction for the treatment of DKD by TCM.

关键词

糖尿病肾病线粒体中医药综述

Keywords

diabetic kidney disease （DKD）mitochondriontraditional Chinese medicinereview

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