Modified Qianghuo Shengshitang Combined with Ozone Injection and Radiofrequency Thermocoagulation Target Puncture in Treatment of Cervical Spondylotic Radiculopathy with Wind-cold Blockage Type

ZHANG Pan; WANG Qinjian; XU Dongkang; JIANG Xingfu; LI Bobo

doi:10.13422/j.cnki.syfjx.202201729

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Modified Qianghuo Shengshitang Combined with Ozone Injection and Radiofrequency Thermocoagulation Target Puncture in Treatment of Cervical Spondylotic Radiculopathy with Wind-cold Blockage Type

更新时间：2022-12-08

- Modified Qianghuo Shengshitang Combined with Ozone Injection and Radiofrequency Thermocoagulation Target Puncture in Treatment of Cervical Spondylotic Radiculopathy with Wind-cold Blockage Type
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 1, Pages: 91-96(2023)
- 作者机构：
  
  河南省中医院/河南中医药大学第二附属医院，郑州 450002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.202201729
  CLC： R22;R242;R2-031;R287
- Received：07 May 2022，
  
  Published Online：21 July 2022，
  
  Published：05 January 2023
- 稿件说明：
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张攀,王勤俭,徐冬康等.羌活胜湿汤加减联合臭氧注射、射频热凝靶点穿刺术治疗神经根型颈椎病风寒痹阻型临床观察[J].中国实验方剂学杂志,2023,29(01):91-96.

ZHANG Pan,WANG Qinjian,XU Dongkang,et al.Modified Qianghuo Shengshitang Combined with Ozone Injection and Radiofrequency Thermocoagulation Target Puncture in Treatment of Cervical Spondylotic Radiculopathy with Wind-cold Blockage Type[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(01):91-96.
张攀,王勤俭,徐冬康等.羌活胜湿汤加减联合臭氧注射、射频热凝靶点穿刺术治疗神经根型颈椎病风寒痹阻型临床观察[J].中国实验方剂学杂志,2023,29(01):91-96. DOI： 10.13422/j.cnki.syfjx.202201729.

ZHANG Pan,WANG Qinjian,XU Dongkang,et al.Modified Qianghuo Shengshitang Combined with Ozone Injection and Radiofrequency Thermocoagulation Target Puncture in Treatment of Cervical Spondylotic Radiculopathy with Wind-cold Blockage Type[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(01):91-96. DOI： 10.13422/j.cnki.syfjx.202201729.

摘要

目的

观察羌活胜湿汤加减联合臭氧注射、射频热凝靶点穿刺术治疗神经根型颈椎病（风寒痹阻型）的临床疗效。

方法

选择2020年8月至2021年5月于河南省中医院治疗的68例神经根型颈椎病患者，以随机数字表法分组，34例患者为观察组，患者为对照组，对照组给予羌活胜湿汤安慰剂颗粒，同时予臭氧注射、射频热凝靶点穿刺术治疗，观察组给予羌活胜湿汤加减联合臭氧注射、射频热凝靶点穿刺术治疗，治疗前后检测两组患者肿瘤坏死因子-

（TNF-

）、降钙素原（PCT）、白细胞介素-2（IL-2）、白细胞介素-1

（IL-1

）、6-酮前列腺素E1

（6-keto-PGE1

）、血浆P物质（SP）、

内啡肽（

-EP）、脂质过氧化物（LPO）、丙二醛（MDA）、超氧化物歧化酶（SOD）水平，给予患者疼痛视觉量表（VAS）、颈椎功能障碍指数量表（NDI）、颈椎病临床评价量表（CASCS）评价，观察临床疗效。

结果

与本组治疗前比较，治疗后两组患者IL-1

、PCT、TNF-

水平降低，IL-2水平升高（

0.05）；治疗后与对照组比较，观察组IL-1

、PCT、TNF-

、IL-2改善更明显（

0.05）。与本组治疗前比较，治疗后两组患者SOD水平升高，LPO、MDA水平降低（

0.05）；治疗后与对照组比较，观察组SOD、LPO、MDA改善更明显（

0.05）。与本组治疗前比较，治疗后两组患者SP、6-keto-PGE1

水平降低，

-EP水平升高（

0.05）；治疗后与对照组比较，观察组SP、6-keto-PGE1

、

-EP改善更明显（

0.05）。与本组治疗前比较，治疗后观察组VAS、NDI评分降低，CASCS评分升高（

0.05）；治疗后与对照组比较，观察组VAS、NDI、CASCS评分改善更明显（

0.05）。治疗后，观察组患者总有效率高于对照组（

=2.018，

0.05）。

结论

羌活胜湿汤加减联合臭氧注射、射频热凝靶点穿刺术治疗神经根型颈椎病（风寒痹阻型）患者，可抑制患者炎症，清除氧自由基，改善疼痛介质水平，缓解患者疼痛，提升颈椎功能及临床疗效。

Abstract

Objective

To observe the clinical efficacy of Qianghuo Shengshitang combined with ozone injection and radiofrequency thermocoagulation target puncture in the treatment of cervical spondylotic radiculopathy （wind-cold blockage type）.

Method

Sixty-eight patients with cervical spondylotic radiculopathy who were treated in Henan Province Hospital of Traditional Chinese Medicine from August 2020 to May 2021 were included and grouped into a control group and a research group by random number table， with 34 patients in each group. The control group was administrated with placebo granules of Qianghuo Shengshitang， and treated with ozone injection and radiofrequency thermocoagulation target puncture at the same time. The research group was given modified Qianghuo Shengshitang combined with ozone injection and radiofrequency thermocoagulation target puncture. Before and after treatment， patients in two groups were tested for the levels of tumor necrosis factor-

（TNF-

）， procalcitonin （PCT）， interleukin-2 （IL-2）， interleukin-1

（IL-1

）， 6-ketoprostaglandin E1

（6-keto-PGE1

）， plasma substance P （SP），

-endorphin （

-EP）， lipid peroxide （LPO）， malondialdehyde （MDA）， and superoxide dismutase （SOD）. The pain visual scale （VAS）， cervical dysfunction index （NDI）， and clinical evaluation scale for cervical spondylosis （CASCS） were given to patients to evaluate the clinical efficacy.

Result

Compared with those before treatment， the levels of IL-1

， PCT， and TNF-

in two groups were decreased， and the level of IL-2 was increased （

0.05）. The improvement of IL-1

， PCT， TNF-

， and IL-2 was more obvious in the research group as compared with the control group （

0.05）. After treatment， the levels of SOD in two groups were increased， while the levels of LPO and MDA were decreased （

0.05）. After treatment， the improvement of SOD， LPO， and MDA was more obvious in the research group as compared with the control group （

0.05）. Compared with those before treatment， the levels of SP and 6-keto-PGE1

in two groups were decreased after treatment， and the level of

-EP was increased （

0.05）. The improvement of -keto-PGE1

and

-EP was more obvious in the research group as compared with the control group after treatment （

0.05）. Compared with those before treatment， the VAS and NDI scores of the research group were decreased， and the CASCS scores were increased （

0.05）. After treatment， the improvement of VAS， NDI， and CASCS of the research group was more obvious as compared with the control group （

0.05）. After treatment， the total effective rate of patients in the research group was higher than that in the control group （

=2.018，

0.05）.

Conclusion

Modified Qianghuo Shengshitang combined with ozone injection and radiofrequency thermocoagulation target puncture in the treatment of patients with cervical spondylotic radiculopathy （wind-cold blockage type） can inhibit inflammation， remove oxygen free radicals， improve the level of pain mediators， relieve pain， and improve cervical spine function and clinical efficacy.

关键词

Keywords

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