Clinical Observation on Treatment of Diabetic Foot Ulcer of Wagner Grade 1-2 by Compound Huangbai Liquid Fomentation

XU Lei; FAN Weijing; WANG Xuhong; LIU Guobin

doi:10.13422/j.cnki.syfjx.202202125

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Clinical Observation on Treatment of Diabetic Foot Ulcer of Wagner Grade 1-2 by Compound Huangbai Liquid Fomentation

更新时间：2023-02-15

- Clinical Observation on Treatment of Diabetic Foot Ulcer of Wagner Grade 1-2 by Compound Huangbai Liquid Fomentation
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 6, Pages: 104-110(2023)
- 作者机构：
  
  上海中医药大学附属曙光医院，上海 200120
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.202202125
  CLC： R22;R242;R2-031;R287
- Published：20 March 2023，
  
  Published Online：13 September 2022，
  
  Received：19 April 2022，
- 稿件说明：
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徐磊,樊炜静,王徐红等.复方黄柏液中医外治溻渍法治疗Wagner1~2级糖尿病足的临床观察[J].中国实验方剂学杂志,2023,29(06):104-110.

XU Lei,FAN Weijing,WANG Xuhong,et al.Clinical Observation on Treatment of Diabetic Foot Ulcer of Wagner Grade 1-2 by Compound Huangbai Liquid Fomentation[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(06):104-110.
徐磊,樊炜静,王徐红等.复方黄柏液中医外治溻渍法治疗Wagner1~2级糖尿病足的临床观察[J].中国实验方剂学杂志,2023,29(06):104-110. DOI： 10.13422/j.cnki.syfjx.202202125.

XU Lei,FAN Weijing,WANG Xuhong,et al.Clinical Observation on Treatment of Diabetic Foot Ulcer of Wagner Grade 1-2 by Compound Huangbai Liquid Fomentation[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(06):104-110. DOI： 10.13422/j.cnki.syfjx.202202125.

摘要

目的

观察复方黄柏液中医外治溻渍法治疗Wagner1~2级糖尿病足溃疡的临床疗效。

方法

通过使用随机对照试验设计的方式，将两组患者分为观察组与对照组，每组41例，两组患者在采用常规治疗的基础上分别采用复方黄柏液中医外治溻渍法与纳米银医用抗菌敷料的治疗方式，并观察两组患者治疗前后的溃疡面积、溃疡深度、中医证候评分、踝肱指数、经皮氧分压、血管内皮生长因子、表皮生长因子、晚期糖基化终末产物、超敏C-反应蛋白、白细胞介素-6、红细胞沉降率、不良事件。

结果

与本组治疗前比较，两组患者治疗后溃疡面积、溃疡深度、中医证候评分、晚期糖基化终末产物、超敏C-反应蛋白、白细胞介素-6、红细胞沉降率均明显降低（

0.05），踝肱指数、经皮氧分压、血管内皮生长因子、表皮生长因子均明显升高（

0.05）；治疗后与对照组比较，观察组溃疡面积、溃疡深度、中医证候评分、血管内皮生长因子、表皮生长因子、晚期糖基化终末产物、超敏C-反应蛋白、白细胞介素-6、红细胞沉降率明显降低（

0.05），踝肱指数、经皮氧分压、血管内皮生长因子、表皮生长因子明显升高（

0.05）；观察组临床疗效优于对照组（

=4.561，

0.05）；两组不良事件与终点事件发生差异无统计学意义。

结论

复方黄柏液中医外治溻渍法对Wagner1~2级糖尿病足溃疡的治疗有显著效果，有利于促进糖尿病足溃疡的愈合，为复方黄柏液与中药溻渍法的进一步临床推广提供了临床证据。

Abstract

Objective

To observe the clinical efficacy of compound Huangbai liquid fomentation on diabetic foot ulcer of Wagner grade 1-2.

Method

Patients were classified into the observation group and control group， with 41 cases in either group. The observation group received routine therapy and compound Huangbai liquid fomentation， while the control group was treated by routine therapy and medical silver nanoparticles-containing dressing. Ulcer area， ulcer depth， traditional Chinese medicine （TCM） syndrome score， ankle-brachial index， transcutaneous oxygen pressure， vascular endothelial growth factor， epidermal growth factor， advanced glycation end product， high-sensitivity C-reactive protein， interleukin-6， erythrocyte sedimentation rate， and adverse events were observed before and after treatment in two groups.

Result

After treatment， the ulcer area， ulcer depth， TCM syndrome score， vascular endothelial growth factor， epidermal growth factor， advanced glycation end product， high-sensitivity C-reactive protein， interleukin-6（IL-6）， and erythrocyte sedimentation rate were lower than those before treatment in two groups （

0.05）， and ankle-brachial index， transcutaneous oxygen pressure， vascular endothelial growth factor， and epidermal growth factor were higher than those before treatment in two groups （

0.05）. After treatment， the ulcer area， ulcer depth， TCM syndrome score， advanced glycation end product， high-sensitivity C-reactive protein， IL-6， and erythrocyte sedimentation rate were lower in the observation group than in the control group （

0.05）， and ankle-brachial index， transcutaneous oxygen pressure， vascular endothelial growth factor， and epidermal growth factor were higher in the observation group than in the control group （

0.05）. The clinical efficacy of observation group was better than that of the control group （

0.05）. There was no significant difference in the incidence of adverse events and endpoint events between two groups.

Conclusion

Compound Huangbai liquid fomentation is effective for diabetic foot ulcer of Wagner grade 1-2， as it is beneficial to the healing of the ulcer. This study provides clinical evidence for the further promotion of Chinese medicine fomentation.

关键词

糖尿病足溃疡Wagner1~2级复方黄柏液中药溻渍法中医外治

Keywords

diabetic foot ulcerWagner grade 1-2compound Huangbai liquidChinese medicine fomentationexternal treatment of Chinese medicine

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