Clinical Treatment of Insomnia with Syndrome of Qi Stagnation and Blood Stasis by Uyghur Medicine Yangxin Dawayimicol Honey Ointment

Ke XUE; Shu-zhang YUAN; Lan-hua AN; Xiao-shan HUI; Jin-sheng ZHANG

doi:10.13422/j.cnki.syfjx.20220493

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Clinical Treatment of Insomnia with Syndrome of Qi Stagnation and Blood Stasis by Uyghur Medicine Yangxin Dawayimicol Honey Ointment

更新时间：2022-01-13

- Clinical Treatment of Insomnia with Syndrome of Qi Stagnation and Blood Stasis by Uyghur Medicine Yangxin Dawayimicol Honey Ointment
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 28, Issue 4, Pages: 124-129(2022)
- 作者机构：
  
  1.新乡市第一人民医院，河南新乡 453000
  2.河南中医药大学，郑州 450046
  3.中国中医科学院广安门医院，北京 100053
  4.河南中医药大学第三附属医院，郑州 450008
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20220493
  CLC： R242;R285.5;R2-031;R259;R256.23
- Received：02 June 2021，
  
  Published Online：17 December 2021，
  
  Published：20 February 2022
- 稿件说明：
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薛珂,袁书章,安兰花等.养心达瓦依米西克蜜膏治疗气滞血瘀证失眠的临床观察[J].中国实验方剂学杂志,2022,28(04):124-129.

XUE Ke,YUAN Shu-zhang,AN Lan-hua,et al.Clinical Treatment of Insomnia with Syndrome of Qi Stagnation and Blood Stasis by Uyghur Medicine Yangxin Dawayimicol Honey Ointment[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(04):124-129.
薛珂,袁书章,安兰花等.养心达瓦依米西克蜜膏治疗气滞血瘀证失眠的临床观察[J].中国实验方剂学杂志,2022,28(04):124-129. DOI： 10.13422/j.cnki.syfjx.20220493.

XUE Ke,YUAN Shu-zhang,AN Lan-hua,et al.Clinical Treatment of Insomnia with Syndrome of Qi Stagnation and Blood Stasis by Uyghur Medicine Yangxin Dawayimicol Honey Ointment[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(04):124-129. DOI： 10.13422/j.cnki.syfjx.20220493.

摘要

目的

评价养心达瓦依米西克蜜膏治疗气滞血瘀证失眠的临床疗效及安全性。

方法

选择2019年11月至2020年10月就诊于河南中医药大学第三附属医院脑病科门诊部符合纳入标准的80例失眠患者，按治疗方法随机分为观察组48例、对照组32例。观察组给予养心达瓦依米西克蜜膏+血府逐瘀胶囊模拟剂，对照组给予血府逐瘀胶囊+养心达瓦依米西克蜜膏模拟剂，两组疗程均为8周。对比两组匹兹堡睡眠质量评分（PSQI），中医证候积分，失眠严重程度指数评分（ISI），神经递质指标［

-氨基丁酸（GABA），谷氨酸（Glu）和5-羟色胺（5-HT）］，血清炎症指标［白细胞介素-6（IL-6）和白细胞介素-10（IL-10）］及安全性指标的变化情况。

结果

观察组总有效率为97.83%（45/46），明显高于对照组的68.75%（22/32），差异有统计学意义（

=-4.292，

0.01）；治疗后，与对照组比较，观察组PSQI评分，ISI评分，中医证候积分，睡眠时长方面均优于对照组，差异有统计学意义（

0.05），在缩短入睡时间及不良反应发生率上两组疗效相当；观察组能提升患者血清中GABA，5-HT，IL-10含量，抑制Glu，IL-6含量。

结论

养心达瓦依米西克蜜膏治疗失眠（气滞血瘀证）疗效确切，安全可靠。

Abstract

Objective

To evaluate the clinical efficacy and safety of Yangxin Dawayimicol honey ointment （YDHO） in the treatment of insomnia with the syndrome of Qi stagnation and blood stasis.

Method

Eighty insomnia patients who met the inclusion criteria in the Department of Encephalopathy of the Third Affiliated Hospital of Henan University of Chinese Medicine from November 2019 to October 2020 were randomly divided into an experimental group （48 cases） and a control group （32 cases）. The experimental group was treated with YDHO + Xuefu Zhuyu capsule simulators，and the control group was treated with Xuefu Zhuyu capsules + YDHO simulators for eight weeks. The changes in Pittsburgh sleep quality index（PSQI）score，traditional Chinese medicine （TCM） syndrome score，insomnia severity index （ISI），neurotransmitter indexes ［

-aminobutyric acid（GABA），glutamic acid（Glu），and 5-hydroxy tryptamine（5-HT）］，serum inflammatory indexes ［interleukin-6（IL-6）and interleukin-10（IL-10）］， and safety index of the two groups were compared.

Result

The total effective rate was 97.83%（45/46） in the experimental group， higher than 68.75%（22/32） in the control group（

=-4.292，

0.01）. The experimental group was superior to the control group in PSQI score，ISI score，TCM syndrome score， and sleep duration（

0.05）. The curative effects were equivalent between the two groups in shortening the time to fall asleep. The experimental group showed increased serum content of GABA，5-HT， and IL-10 and reduced content of Glu and IL-6，with few adverse reactions （

0.05）.

Conclusion

YDHO is effective，safe， and reliable in the treatment of insomnia with Qi stagnation and blood stasis syndrome.

关键词

Keywords

references

VARGAS I ， NGUYEN A M ， MUENCH A ， etal . Acute and chronic insomnia：what has time and/or hyperarousal got to do with it？［J］. Brain Sci ， 2020 ， 10 （ 2 ）， 71 .

王丽敏，关云琦 . 睡眠状况与主要慢性病患病的关系［J］. 中华流行病学杂志， 2020 ， 41 （ 8 ）： 1237 - 1241 .

李越峰，吴红伟，李东辉，等 . 信号通路与失眠相关性研究进展［J］. 中国临床药理学杂志， 2021 ， 37 （ 14 ）： 1928 - 1931，1946 .

胡尔西代姆·热合麦提 . 维药宝心艾维西木口服液联合养心达瓦依米西克蜜膏治疗慢性稳定型心绞痛的临床疗效观察［J］. 世界最新医学信息文摘（连续型电子期刊）， 2019 ， 19 （ 65 ）： 242 - 243 .

American Psychiatric Association . Diagnostic and statistical manual of mental disorders，fifth edition（DSM-5）［M］. Arlington ： American Psychiatric Association ， 2013 .

张伯礼，吴勉华 . 中医内科学［M］. 10版 . 北京：中国中医药出版社， 2017 ： 146 - 153 .

郑筱萸 . 中药新药临床研究指导原则［M］. 北京：中国医药科技出版社， 2002 ： 4 .

麦麦提艾力·依甘拜尔迪，穆丹丹，宋菲 . 维吾尔药养心达瓦依米西克蜜膏临床应用研究进展［J］. 临床医药文献电子杂志， 2019 ， 6 （ 27 ）： 195 - 196 .

安素红，魏玉群 . 血府逐瘀胶囊联合地西泮片治疗顽固性失眠40例［J］. 河北中医， 2007 ， 29 （ 3 ）： 253 .

梅世明 . 血府逐瘀汤治疗顽固性失眠临床观察［J］. 中医学报， 2011 ， 26 （ 10 ）： 1244 - 1245 .

师卿杰 . 血府逐瘀汤加减治疗老年人顽固性失眠60例［J］. 山东中医杂志， 2010 ， 29 （ 7 ）： 446 - 448 .

杜中平，石可松 . 血府逐瘀汤配合针灸治疗冠心病心绞痛的疗效研究［J］. 中国全科医学， 2021 ， 24 （ S1 ）： 158 - 160 .

姚高磊，郑晓燕，陆丽明，等 . 血府逐瘀汤加味治疗顽固性失眠的Meta分析［J］. 按摩与康复医学， 2021 ， 12 （ 9 ）： 67 - 72 .

沈子涵，王仁和，张栏译，等 . 先秦两汉时期对不寐病因病机的认识［J］. 中国中医基础医学杂志， 2019 ， 25 （ 9 ）： 1197 - 1199 .

蒋晓江，许志强，刘娟 . 内因性失眠症患者中枢抑制源GABA震荡的脑电涨落变化［J］. 中国临床神经科学， 2005 ， 13 （ 3 ）： 236 - 238 .

付乙 . 中药对运动性失眠单胺类神经递质和免疫功能的影响［J］. 四川中医， 2004 ， 22 （ 4 ）： 13 - 15 .

楚仁 . 与失眠及疲倦有关的白细胞介素-6 ［J］. 国外医学情报， 1999 （ 9 ）： 45 - 46 .

IRWIN M R ， OLMSTEAD R ， CARROLL J E . Sleep disturbance，sleep duration，and inflammation：a systematic review and Meta-analysis of cohort studies and experimentalsleep deprivation ［J］. Biol Psychiatry ， 2016 ， 80 （ 1 ）： 40 - 52 .

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