Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining

Lingxiao ZHAO; Hong LYU; Xinghua HU; Yuan GAO; Houli LIU; Ling LI; Jianqin XU

doi:10.13422/j.cnki.syfjx.20220911

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Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining

更新时间：2022-09-01

- Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 28, Issue 14, Pages: 158-164(2022)
- 作者机构：
  
  1.陕西中医药大学研究生院，陕西咸阳 710042
  2.陕西省中医医院，西安 710003
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20220911
  CLC： R285;R289;R22;R2-031;R33
- Received：01 February 2022，
  
  Published Online：20 May 2022，
  
  Published：20 July 2022
- 稿件说明：
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赵凌霄,吕红,呼兴华等.基于数据挖掘探讨黄连在糖尿病及其并发症复方中的应用规律[J].中国实验方剂学杂志,2022,28(14):158-164.

ZHAO Lingxiao,LYU Hong,HU Xinghua,et al.Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(14):158-164.
赵凌霄,吕红,呼兴华等.基于数据挖掘探讨黄连在糖尿病及其并发症复方中的应用规律[J].中国实验方剂学杂志,2022,28(14):158-164. DOI： 10.13422/j.cnki.syfjx.20220911.

ZHAO Lingxiao,LYU Hong,HU Xinghua,et al.Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(14):158-164. DOI： 10.13422/j.cnki.syfjx.20220911.

摘要

目的

基于数据挖掘探讨黄连在糖尿病及其并发症复方中的应用规律。

方法

检索并收集现代医家的医案中含有黄连治疗糖尿病及其并发症的方剂及对应的证型、症状的数据共288条（其中黄连治疗糖尿病218条，黄连治疗糖尿病并发症70条），运用“中医传承计算平台（V3.0）”对该方药组成进行数据挖掘分析，利用该平台的频数统计、方剂分析、症状分析、关联规则、网络可视化图、聚类分析等进行数据挖掘。

结果

对288条数据挖掘分析，方案1：218首含黄连治疗糖尿病的方剂中，共包含中药190味，对含有黄连的处方证型频率统计，出现频数≥6次的证候有12种，其中出现频率最高的是气阴两虚证，其后依次为肺胃热盛证、阴虚火旺证、热盛津伤证等。黄连治疗糖尿病的用量为1.5~30 g，频数最高位于前三的用量为10、6、5 g，相对应医案中症状频数最高是大便干结、口干舌燥、消谷善饥，通过关联规则和聚类分析共得出26条核心药对、17条关联规则、3张药物关系图以及3个核心组合。方案2：70首含黄连治疗糖尿病并发症的方剂中，共包含有184味中药，黄连治疗糖尿病并发症的疾病分布排名前3的为糖尿病肾病、糖尿病周围神经病变、糖尿病胃肠病变，黄连治疗糖尿病并发症的用量及频数分析可见黄连的用量为2~15 g，频数最高位于前三的用量为10、6、5 g。

结论

含黄连治疗糖尿病及其并发症的方剂，多兼有湿热化火、热盛伤阴症状。本次总结黄连用量规律，为临床规范使用黄连防治糖尿病及其并发症提供了参考。

Abstract

Objective

To explore the application law of compound prescriptions containing Coptidis Rhizoma to diabetes and its complications based on data mining.

Method

A total of 288 records on formulas containing Coptidis Rhizoma in the treatment of diabetes and its complications and the corresponding syndromes and symptoms were retrieved from the medical records of modern physicians， with 218 on the treatment of diabetes and 70 on the treatment of diabetes complications. The Traditional Chinese Medicine Inheritance Computing Platform （V3.0） was used or data mining on the compositions of the formulas. Moreover， it was employed for the frequency statistics， formula analysis， symptom analysis， association rules analysis， network visualization， and cluster analysis.

Result

The 218 formulas containing Coptidis Rhizoma for the treatment of diabetes involved 190 Chinese medicinals. A total of 12 syndromes showed the occurrence frequency ≥ 6， and the one with the highest frequency was deficiency of both qi and yin， followed by the syndrome of excessive heat in lung and stomach， syndrome of Yin deficiency and effulgent fire， and syndrome of excessive heat and fluid consumption. The dose of Coptidis Rhizoma for the treatment of diabetes ranged from 1.5-30 g， and the most frequently used doses were 10， 6， and 5 g. The medicinal was frequently applied for the traditional Chinese medicine symptoms of dry stool， dry mouth and tongue， and swift digestion with rapid hungering. Moreover， 26 core medicinal pairs， 17 association rules， 3 diagrams on medicinal relationship， and 3 core combinations were yielded. The 70 formulas containing Coptidis Rhizoma for the treatment of diabetes complications involved 184 Chinese medicinals， and the top 3 complications were diabetic nephropathy， diabetic peripheral neuropathy， and diabetic gastroenteropathy. The dose of Coptidis Rhizoma in the treatment of diabetes complications fell in the range of 2-15 g， and 10， 6， and 5 g were most frequently used.

Conclusion

Formulas containing Coptidis Rhizoma for the treatment of diabetes and its complications mainly target the syndrome of dampness-heat transforming into fire and the syndrome of excessive heat damaging yin. This study can serve as a reference for standard use of Coptidis Rhizoma in the prevention and treatment of diabetes and its complications.

关键词

Keywords

references

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