Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine： A Bibliometric Analysis Based on Multiple Software

HUI Xiaoshan; LU Shichao; LIU Yongmei; WANG Shiqi; ZHOU Siyuan; ZHANG Jinsheng; WANG Jie

doi:10.13422/j.cnki.syfjx.20221115

您当前的位置：

首页 >

文章列表页 >

Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine： A Bibliometric Analysis Based on Multiple Software

更新时间：2022-12-08

- Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine： A Bibliometric Analysis Based on Multiple Software
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 1, Pages: 155-162(2023)
- 作者机构：
  
  1.中国中医科学院广安门医院，北京 100053
  2.广州中医药大学惠州医院，广东惠州 516000
  3.河南中医药大学第一附属医院，郑州 450046
  4.河南中医药大学第三附属医院，郑州 450046
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20221115
  CLC： R285;R289;R22;R2-031;R33
- Received：05 December 2021，
  
  Published Online：10 July 2022，
  
  Published：05 January 2023
- 稿件说明：
移动端阅览
惠小珊,陆诗超,刘咏梅等.基于多分析方法联合的中医药调控mTOR通路文献计量学及可视化分析[J].中国实验方剂学杂志,2023,29(01):155-162.

HUI Xiaoshan,LU Shichao,LIU Yongmei,et al.Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine： A Bibliometric Analysis Based on Multiple Software[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(01):155-162.
惠小珊,陆诗超,刘咏梅等.基于多分析方法联合的中医药调控mTOR通路文献计量学及可视化分析[J].中国实验方剂学杂志,2023,29(01):155-162. DOI： 10.13422/j.cnki.syfjx.20221115.

HUI Xiaoshan,LU Shichao,LIU Yongmei,et al.Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine： A Bibliometric Analysis Based on Multiple Software[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(01):155-162. DOI： 10.13422/j.cnki.syfjx.20221115.

摘要

目的

通过对中医药调控哺乳动物雷帕霉素靶蛋白（mTOR）通路文献进行多软件联系可视化计量分析，梳理该领域的研究进展为相关领域研究提供借鉴与参考。

方法

以Web of Science核心集数据库中医药调控mTOR通路相关文献为研究对象，运用Citespace、VOSviewer、carrort

等软件，对其进行文献计量学可视化分析。

结果

经检索符合要求文献245篇，可视化分析结果发现文章2010年后发文开始逐年呈波动性递增趋势，2018年研究成果大量涌现；中国是发文最多的国家；发文量较多的机构主要在北京与上海，多以北京和南京为中心的区域间合作为主；根据发文作者研究方向，结合研究聚焦热点发现近年来中医药干预mTOR通路领域主要集中在其抗肿瘤、抗凋亡及抗炎等方面；中医药干预mTOR通路调控细胞凋亡（cell apoptosis）、自噬（autophagy）、增殖（proliferation）、死亡（death）；AMP依赖蛋白激酶（AMPK）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）/mTOR通路等方面是目前及今后的研究热点。

结论

中医药调控mTOR通路研究发展前景良好，通过对此深入研究可能为心血管、肿瘤等重大疾病的治疗提供新的思路与导向。

Abstract

Objective

To summarize the research progress of mammalian target of rapamycin （mTOR） pathway regulated by traditional Chinese medicine（TCM） and provide reference for visualization and quantitative analysis of related research based on multiple software linkage.

Method

Literature related to TCM regulation of mTOR pathway in Web of Science was taken as the research object. Citespace，VOSviewer，and carrort

were used for biliometric analysis and visualization of the literature.

Result

A total of 245 papers that met the requirements were retrieved，and the visual analysis showed that the papers presented a fluctuating increase year by year after 2010，and numerous research results emerged in 2018. China had the most publications. Institutions with a large number of publications were mainly in Beijing and Shanghai，and most of the regional cooperation was centered in Beijing and Nanjing. According to the research direction and focus，it was found that the intervention of TCM in mTOR pathway in recent years mainly concentrated on the anti-tumor，anti-apoptotic and anti-inflammatory aspects， and TCM interfered with mTOR pathway to regulate cell apoptosis，autophagy，proliferation，and death. AMP-activated protein kinase （AMPK） and phosphatidylinositol 3-kinases（PI3K）/protein kinase B（Akt）/mTOR pathway were the current and future research hotspots.

Conclusion

Research on the regulation of mTOR pathway by TCM had a good prospect，and the in-depth study might provide new ideas and guidance for the treatment of cardiovascular diseases，tumor and other major diseases.

关键词

Keywords

references

CARRERA A C . TOR signaling in mammals ［J］. J Cell Sci . 2004 ， 117 （ 20 ）： 4615 - 4616 .

WULLSCHLEGER S ， LOEWITH R ， HALL M N . TOR signaling in growth and metabolism ［J］. Cell ， 2006 ， 124 （ 3 ）： 471 - 484 .

MEIJER A J ， CODOGNO P . Signalling and autophagy regulation in health，aging and disease ［J］. Mol Aspects Med ， 2006 ， 27 （ 5/6 ）： 411 - 425 .

MIZUSHIMA N ， LEVINE B ， CUERVO A M ， et al . Autophagy fights disease through cellular self-digestion ［J］. Nature ， 2008 ， 451 （ 7182 ）： 1069 - 1075 .

陈悦，陈超美，胡志刚，等 . 引文空间分析原理与应用CiteSpace实用指南［M］. 北京：科学出版社， 2014 ： 27 - 69 .

CHEN C ， CHEN Y . Searching for clinical evidence in CiteSpace ［J］. AMIA Annu Symp Proc ， 2005 ， 2005 ： 121 - 125 .

陈悦，陈超美，刘则渊，等 . CiteSpace知识图谱的方法论功能［J］. 科学学研究， 2015 ， 33 （ 2 ）： 242 - 253 .

SARBASSOV D D ， GUERTIN D A ， ALI S M ， et al . Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex ［J］. Science ， 2005 ， 307 （ 5712 ）： 1098 - 1101 .

LEE D F ， KUO H P ， CHEN C T ， et al . IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway ［J］. Cell ， 2007 ， 130 （ 3 ）： 440 - 455 .

CHEN W ， ZHENG R ， BAADE P D ， et al . Cancer statistics in China，2015 ［J］. CA Cancer J Clin ， 2016 ， 66 （ 2 ）： 115 - 132 .

MIZUSHIMA N ， YOSHIMORI T ， LEVINE B . Methods in mammalian autophagy research ［J］. Cell ， 2010 ， 140 （ 3 ）： 313 - 326 .

SIEGEL R ， MA J ， ZOU Z ， et al . Cancer statistics，2014 ［J］. CA Cancer J Clin ， 2014 ， 64 （ 1 ）： 9 - 29 .

LAPLANTE M ， SABATINI D M . mTOR signaling in growth control and disease ［J］. Cell ， 2012 ， 149 （ 2 ）： 274 - 293 .

BUTLER D E ， MARLEIN C ， WALKER H F ， et al . Inhibition of the PI3K/Akt/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer ［J］. Oncotarget ， 2017 ， 8 （ 34 ）： 56698 - 56713 .

邱均平 . 信息计量学［M］武汉：武汉大学出版社， 2007 ： 91 ．

ZHANG L ， LIANG H ， XIN Y . Cucurbitacin E inhibits esophageal carcinoma cell proliferation， migration， and invasion by suppressing Rac1 expression through PI3K/Akt/mTOR pathway ［J］. Anticancer Drugs ， 2020 ， 31 （ 8 ）： 847 - 855 .

WANG Y ， ZHAO B ， FEI Y ， et al . Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats ［J］. Biosci Rep . 2020 ， 40 （ 7 ）： 1 - 14 .

WU R M ， JIANG B ， LI H ， et al . A network pharmacology approach to discover action mechanisms of Yangxinshi Tablet for improving energy metabolism in chronic ischemic heart failure ［J］. J Ethnopharmacol ， 2020 ， 246 ： 112227 .

WANG L ， HUANG Y ， YIN G ， et al . Antimicrobial activities of Asian ginseng， American ginseng， and notoginseng ［J］. Phytother Res ， 2020 ， 34 （ 6 ）： 1226 - 1236 .

XIE Y ， TIAN L ， FANG Z ， et al . Bushen Kangshuai tablet inhibits progression of atherosclerosis by intervening in macrophage autophagy and polarization ［J］. J Tradit Chin Med ， 2020 ， 40 （ 1 ）： 28 - 37 .

FINDLAY G M ， YAN L ， PROCTER J ， et al . A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling ［J］. Biochem J ， 2007 ， 403 （ 1 ）： 13 - 20 .

CHUANG H C ， TAN T H . MAP4K3/GLK in autoimmune disease，cancer and aging ［J］. J Biomed Sci ， 2019 ， 26 （ 1 ）： 82 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Visual Analysis of Current Status and Hotspots of Research on Ancient Classical Formulas Based on CiteSpace

Antitumor Effect of Fagopyri Dibotryis Rhizoma Extract on Colorectal Cancer Cells Through ROS/MAPK Signaling Pathway

Visualization Analysis of Henoch-schonlein Purpura Treated by Traditional Chinese Medicine Based on Citespace

Improved Learning and Memory in Sleep-deprived Mice by Anmeidan via Cellular Autophagy Regulation Through PI3K/Akt/mTOR Signaling Pathway

Related Author

LI Yu

WANG Jiahao

XUE Hao

WANG Luning

CHEN Renshou

XU Guangya

ZHOU Wenyue

ZHOU Senlin

Related Institution

Nanjing University of Chinese Medicine

College of Food and Bioengineering， School of Preclinical Medicine， Clinical Medical College/Affiliated Hospital， Chengdu University

Beijing University of Chinese Medicine

School of Traditional Chinese Medicine， Hubei University of Chinese Medicine

Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰