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1.河北中医学院 研究生院,石家庄 050091
2.承德医学院,河北 承德 067000
3.沧州市第三医院,河北 沧州 061000
4.云南中医药大学 附属第一医院,昆明 650021
5.河北中医学院 附属沧州中西医结合医院,河北 沧州 061000
Received:31 March 2022,
Published Online:30 June 2022,
Published:05 December 2022
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潘保朝,李函舟,张辉等.中医药调控TGF-β1/Smad信号通路治疗糖尿病肾病的研究进展[J].中国实验方剂学杂志,2022,28(23):237-249.
PAN Baochao,LI Hanzhou,ZHANG Hui,et al.Chinese Medicine Regulating TGF-β1/Smad Signaling Pathway in Treatment of Diabetic Nephropathy: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(23):237-249.
潘保朝,李函舟,张辉等.中医药调控TGF-β1/Smad信号通路治疗糖尿病肾病的研究进展[J].中国实验方剂学杂志,2022,28(23):237-249. DOI: 10.13422/j.cnki.syfjx.20221308.
PAN Baochao,LI Hanzhou,ZHANG Hui,et al.Chinese Medicine Regulating TGF-β1/Smad Signaling Pathway in Treatment of Diabetic Nephropathy: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(23):237-249. DOI: 10.13422/j.cnki.syfjx.20221308.
糖尿病肾病(DN)是糖尿病的严重微血管并发症之一,是终末期肾脏的主要病因。糖尿病肾病的发生发展与肾脏纤维化进展息息相关,研究表明肾脏纤维化是各种慢性肾脏疾病的重要病理特征和最终病理结果。因此,针对肾脏纤维化的治疗有利于延缓DN的疾病进展。转化生长因子-
β
1
(TGF-
β
1
)/Smad信号通路是肾脏纤维化的关键信号通路之一,TGF-
β
1
是介导肾脏纤维化的关键因子,在与纤维化有关的肾脏疾病中呈现出高表达状态,Smads蛋白是TGF-
β
1
信号转导通路中下游主要效应分子,TGF-
β
1
通过激活Smads蛋白将信号从胞质异位到细胞核中,并调节与纤维化相关靶基因的转录,从而发挥生物学效应促进肾脏纤维化进程。近年来中医药在DN的防治中起到越来越重要的作用,探索中医药通过调控TGF-
β
1
/Smad信号通路预防和治疗DN的研究也日益增多。基于中医药研究现状,该文查阅相关文献,通过综述TGF-
β
1
/Smad信号通路的基本结构及其与DN的关系,中药单体及提取物、中成药及中药复方基于TGF-
β
1
/Smad信号通路改善和延缓肾脏纤维化的研究现状及其通过调节TGF-
β
1
/Smad信号通路起到缓解炎症反应及氧化应激、减少细胞外基质的累积和抑制上皮间质转化等作用,旨在为DN的防治提供新思路和方向。
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and the leading cause of end-stage kidney disease. The onset and progression of DN are linked to the progression of renal fibrosis which is an important pathological feature and final pathological result of various chronic kidney diseases. As a result, therapies against renal fibrosis can help delay the progression of DN. The transforming growth factor-
β
1
(TGF-
β
1
)/Smad signaling pathway is one of the key pathways in renal fibrosis. TGF-
β
1
, a crucial mediator of renal fibrosis, is highly expressed in the case of fibrosis-associated kidney diseases, and Smads are the main effectors in the TGF-
β
1
signal transduction pathway. By activating Smads, TGF-
β
1
transports signals from the cytoplasm to the nucleus and regulates the transcription of fibrosis-related target genes, thus exerting the biological effects and promoting the progression of renal fibrosis. In recent years, Chinese medicine has become prominent in the prevention and treatment of DN, and there has been an explosion of research on Chinese medicine in the prevention and treatment of DN through the TGF-
β
1
/Smad signaling pathway. Based on literature research, this paper reviewed the basic structure of the TGF-
β
1
/Smad signaling pathway, the relationship with DN, and monomers and extract of Chinese medicine, Chinese patent medicine, and compound Chinese medicine prescriptions in improving and delaying the renal fibrosis based on the TGF-
β
1
/Smad signaling pathway, and in alleviating inflammatory response and oxidative stress, reducing the accumulation of extracellular matrix, and inhibiting epithelial-mesenchymal transition by regulating the TGF-
β
1
/Smad signaling pathway. Thereby, this study is expected to provide new mindset for the treatment of DN.
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