浏览全部资源
扫码关注微信
河南中医药大学 药学院,郑州 450046
Published:05 March 2023,
Published Online:08 September 2022,
Received:30 March 2022,
扫 描 看 全 文
李紫东,方晓艳,苗明三.基于文献分析中药皂苷类治疗脑缺血再灌注的作用机制[J].中国实验方剂学杂志,2023,29(05):194-203.
LI Zidong,FANG Xiaoyan,MIAO Mingsan.Mechanism of Chinese Medicine Saponins in Treatment of Cerebral Ischemia-reperfusion Based on Literature Analysis[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(05):194-203.
李紫东,方晓艳,苗明三.基于文献分析中药皂苷类治疗脑缺血再灌注的作用机制[J].中国实验方剂学杂志,2023,29(05):194-203. DOI: 10.13422/j.cnki.syfjx.20221513.
LI Zidong,FANG Xiaoyan,MIAO Mingsan.Mechanism of Chinese Medicine Saponins in Treatment of Cerebral Ischemia-reperfusion Based on Literature Analysis[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(05):194-203. DOI: 10.13422/j.cnki.syfjx.20221513.
脑缺血再灌注是一种发病率高、死亡率高的严重脑血管疾病。近年来,以溶栓、取栓为基础的再灌注治疗是缺血性脑卒中患者的主要治疗方法。众多研究表明中药皂苷类成分可有效干预脑缺血再灌注,中药皂苷干预脑缺血再灌注具有多靶点、多途径的特点和显著效果,在治疗与预防脑缺血再灌注上显示巨大的潜力。该文以中国知网文献数据库和万方文献数据库为分析来源,SPSS统计归纳用于治疗脑缺血再灌注的中药皂苷的文献数量、CiteSpace对研究的高频关键词进行聚类分析,阐述用于治疗脑缺血再灌注的中药皂苷的研究热点及研究现状。基于文献分析总结近二十年对中药皂苷治疗脑缺血再灌注的动物实验,中药皂苷通过抗炎作用、抑制氧化应激、免疫调节、保护神经细胞、抑制血栓形成和促进溶栓、保护线粒体、修复血脑屏障等途径治疗脑缺血再灌注,归纳各中药皂苷的具体作用机制、治疗效果和信号通路,为中药皂苷治疗脑缺血再灌注的深入研究、新药研发与临床应用提供理论依据。
Cerebral ischemia-reperfusion is a serious cerebrovascular disease with high morbidity and mortality. In recent years, reperfusion therapy based on thrombolysis and thrombectomy has been the main treatment method for patients with ischemic stroke. Numerous studies have shown that Chinese medicine saponins can effectively interfere with cerebral ischemia-reperfusion in a multi-target and multi-way manner, which have great potential on the treatment and prevention of cerebral ischemia-reperfusion. Taking China National Knowledge Infrastructure (CNKI) literature database and Wanfang literature database as the analysis sources, this paper used SPSS statistics to summarize the number of papers on the treatment of cerebral ischemia-reperfusion with Chinese medicine saponins and CiteSpace to conduct cluster analysis on the high-frequency keywords of the research, thereby expounding the research hotspots and research status of Chinese medicine saponins in the treatment of cerebral ischemia-reperfusion. Based on literature analysis and summary of animal experiments on the treatment of cerebral ischemia-reperfusion with Chinese medicine saponins in the past two decades, Chinese medicine saponins exerted effects by anti-inflammation, inhibition of oxidative stress, immune regulation, protection of nerve cells, inhibition of thrombosis, promotion of thrombolysis, protection of mitochondria, blood-brain barrier repairing, and other ways. The specific mechanism, therapeutic effect, and signaling pathway of each Chinese medicine saponin have been summarized in this study, which provide a theoretical basis for the in-depth research, new drug development, and clinical application of Chinese medicine saponins for the treatment of cerebral ischemia- reperfusion.
脑缺血再灌注中药皂苷作用机制信号通路
cerebral ischemia-reperfusion injuryChinese medicine saponinsmechanismsignaling pathway
王林琳,康智能,刘文鹏,等.三七总皂苷抑制铁死亡和炎症反应减轻大鼠脑缺血再灌注损伤[J].中国免疫学杂志,2022,38(3):296-300.
曹利华,赵院院,白明,等.基于STAT5信号通路调控Treg免疫功能的毛冬青总皂苷抗脑缺血炎症损伤的分子机制研究[J].中华中医药杂志,2021,36(9):5477-5481.
王文杰,舒升,徐煜彬,等.绞股蓝皂苷ⅩⅦ调控PI3K/Akt信号通路对脑缺血再灌注模型大鼠的保护作用[J].中华中医药学刊,2021,39(3):233-236,276-278.
孙健淇,付旭阳,张若琛,等.瓜子金皂苷己对脑缺血再灌注损伤大鼠NKCC1及炎症因子表达的影响[J].包头医学院学报,2021,37(4):59-63.
黄茸茸,陆松侠,孙玲玲,等.人参皂苷Rg1下调NOX2-NLRP1减轻PC12细胞缺氧再复氧损伤的作用[J].中国药理学通报,2021,37(8):1068-1075.
马大亮,崔红莉,荣卫江,等.柴胡皂苷A减轻脑缺血再灌注大鼠海马神经元损伤[J].中国临床解剖学杂志,2021,39(5):569-574.
段晋宁,向常清,钱爱红,等.珠子参皂苷通过激活PI3K/Akt通路对小鼠脑缺血再灌注损伤的保护作用研究[J].中国临床药理学与治疗学,2019,24(7):750-758.
张三利,盛明月,吴琪,等.鲁斯可皂苷元对脑缺血再灌注损伤小鼠时钟基因的调控作用[J].中国药理学与毒理学杂志,2021,35(7):502-506.
董娜娜,陈晓兰,邓铋莉,等.基于偏最小二乘法分析猪牙皂不同组分对大鼠脑缺血再灌注损伤的影响[J].中国现代应用药学,2022,39(2):141-146.
李媛,靳晓飞,周晓红,等.黄芪甲苷对脑缺血/再灌注损伤大鼠细胞自噬的影响[J].中国病理生理杂志,2018,34(11):2037-2042.
黄亚光,欧炳金,冯家腾,等.竹节参总皂苷调节大鼠海马区自噬减轻脑缺血再灌注损伤[J].中成药,2020,42(7):1721-1726.
LUO T,LIU G,MA H,et al.Inhibition of autophagy via activation of PI3K/Akt pathway contributes to the protection of ginsenoside Rb1 against neuronal death caused by ischemic insults[J].Int J Mol Sci,2014,15(9):15426-15442.
FU X,LIU Y,ZHANG H,et al.Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia[J].Exp Neurol,2021,338:113598.
XU H T,NING N C,XIANG L.Ginsenoside Rg1 improves ischemic brain injury by balancing mitochondrial biogenesis and mitophagy[J].Tropical J Pharmaceut Res,2017,16(10):2469-2475.
丁玲,胡毅,刘洁,等.知母皂苷对大鼠局灶性脑缺血/再灌注损伤的保护作用[J].中国现代应用药学,2018,35(12):1821-1825.
ZHANG X,LIU X,HU G,et al.Ginsenoside Rd attenuates blood-brain barrier damage by suppressing proteasome-mediated signaling after transient forebrain ischemia[J].Neuroreport,2020,31(6):466-472.
丁煌,唐三,杨筱倩,等.冰片配伍黄芪甲苷与三七总皂苷对脑缺血/再灌注后血脑屏障通透性的影响[J].中国药理学通报,2019,35(11):1516-1523.
LIANG C,NI G X,SHI X L,et al.Astragaloside Ⅳ regulates the HIF/VEGF/Notch signaling pathway through miRNA-210 to promote angiogenesis after ischemic stroke[J].Restor Neurol Neurosci,2020,38(3):271-282.
LIU X,ZHANG M,LIU H,et al.Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes[J].Exp Neurol,2021,341:113700.
李艳玲,丁煌,杨芙蓉,等.黄芪甲苷配伍三七总皂苷对脑缺血大鼠BMSCs移植后血管新生的影响[J].中国实验方剂学杂志,2021,27(21):73-79.
CHEN J,ZHANG X,LIU X,et al.Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice[J].Eur J Pharmacol,2019,856:172418.
林军,梁萍,黄清,等.三七总皂苷对脑缺血再灌注大鼠神经血管单元的影响[J].中国药业,2019,28(13):10-14.
徐士欣,马惠宁,王成益,等.三七总皂苷对脑缺血再灌注损伤大鼠缺氧诱导因子1α和基质金属蛋白酶表达的影响[J].中华老年心脑血管病杂志,2016,18(8):859-862.
LI L,GAN H,JIN H,et al.Astragaloside Ⅳ promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats[J].Int Immunopharmacol,2021,92:107335.
黄小平,王蓓,邱咏园,等.黄芪甲苷、人参皂苷Rg1、Rb1和三七皂苷R1抗小鼠脑缺血再灌注氧化应激损伤和促进能量代谢的配伍研究[J].湖南中医药大学学报,2014,34(7):5-11.
HUANG Q,SU H,QI B,et al.A SIRT1 Activator,ginsenoside Rc,promotes energy metabolism in cardiomyocytes and Neurons[J].J Am Chem Soc,2021,143(3):1416-1427.
HUANG X P,TAN H,CHEN B Y,et al.Combination of total Astragalus extract and total Panax notoginseng saponins strengthened the protective effects on brain damage through improving energy metabolism and inhibiting apoptosis after cerebral ischemia-reperfusion in mice[J].Chin J Integr Med,2017,23(6):445-452.
ZHU T,XIE W J,WANG L,et al.Notoginsenoside R1 activates the NAMPT-NAD(+)-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling[J].Biomed Pharmacother,2021,140:111693.
HAN J Y,LI Q,MA Z Z,et al.Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion[J].Pharmacol Ther,2017,177:146-173.
刘韬,朱万芸.微生物发酵三七皂苷抗脑缺血和抗血栓形成作用的研究[J].医学食疗与健康,2020,18(10):1-4,22.
李晶,昌友权,曲红光,等.奇可力皂苷抗脑缺血作用研究[J].食品科学,2005,26(8):392-394.
XIAO B,CHAI Y,LV S,et al.Endothelial cell-derived exosomes protect SH-SY5Y nerve cells against ischemia/reperfusion injury[J].Int J Mol Med,2017,40(4):1201-1209.
吴云虎,陆晖,张永全.酸枣仁皂苷A对大鼠脑缺血海马区氨基酸递质水平及细胞凋亡的影响[J].浙江中西医结合杂志,2009,19(7):403-405.
王璟,卢敏.蒺藜总皂苷对缺血再灌注损伤大鼠视网膜神经细胞凋亡的影响[J].湖北科技学院学报:医学版,2015(3):194-196.
姜红玉,睢大员,于晓风,等.刺五加叶皂苷对实验性脑缺血大鼠血液流变学及血小板功能的影响[J].吉林大学学报:医学版,2004,30(3):384-386.
刘力,徐华丽,曲绍春,等.人参果皂苷注射液对大鼠实验性脑缺血的保护作用[J].中国老年学杂志,2006,26(9):1242-1244.
吴艺帆,傅晨,罗超琴,等.三七总皂苷调控cGAS/STING/NF-κB通路对急性脑梗死大鼠炎症反应的影响[J].北京中医药,2021,40(10):1061-1065.
周玉嘉,张允岭,周晶,等.三七总皂苷对脑缺血再灌注大鼠TLR4/NF-κB信号通路及炎性细胞因子的影响[J].中国中医急症,2021,30(8):1340-1344.
欧阳波,刘晓丹,杨筱倩,等.冰片配伍黄芪甲苷和三七总皂苷通过Notch信号通路对大鼠脑缺血再灌注损伤模型的神经保护作用[J].中草药,2020,51(23):5990-5997.
贾壮壮,袁庆,陈红阳,等.丹参多酚酸配伍三七总皂苷通过调节PI3K/Akt信号通路对大鼠脑缺血/再灌注损伤神经元凋亡的影响[J].中国药理学通报,2020,36(9):1214-1220.
李慢中,欧阳俊摇,杨乐,等.延龄草甾体皂苷对脑缺血大鼠星形胶质细胞GFAP、Cx43及Wnt3a/Dvl3信号通路的影响[J].中国中医药信息杂志,2022,29(5):75-80.
徐玥玮,王丽,高晓明,等.黄芪甲苷对局灶性脑缺血后适应中Wnt/β-catenin信号通路关键因子表达的影响[J].贵州医科大学学报,2022,47(2):171-178.
鄢宇梅,米佳佳,付英豪,等.基于Nrf2/HO-1通路的黄芪-灯盏细辛成分配伍对缺氧缺糖PC12细胞氧化损伤研究[J].中药药理与临床,2022,38(2):159-164.
欧阳波,刘晓丹,杨筱倩,等.冰片配伍黄芪甲苷和三七总皂苷通过Notch信号通路对大鼠脑缺血再灌注损伤模型的神经保护作用[J].中草药,2020,51(23):5990-5997.
史楠,张燕,李晋峰,等.黄芪甲苷通过AKT-mTOR信号通路促进脑缺血的自噬改善脑缺血再灌注损伤[J].中国临床神经科学,2017,25(6):601-612.
任凯迪,彭紫梅,罗秀菊,等.川续断皂苷B抑制线粒体E3泛素连接酶1减轻缺血性中风大鼠脑损伤[J].中国药理学与毒理学杂志,2021,35(10):795.
WANG A R,MI L F,ZHANG Z L,et al.Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway[J].Behav Brain Res,2021,403:113138.
王睿智,陈志文,邵乐,等.人参皂苷Rb1通过调控Nrf2/ARE信号通路抗氧糖剥夺/复氧后神经细胞焦亡的研究[J].中国药理学通报,2021,37(10):1383-1390.
石智珍,白宇,程记伟,等.人参皂苷通过调节HIF-1α-VEGF通路对大鼠脑缺血再灌注损伤的保护作用[J].四川中医,2019,37(6):43-46.
余录,胡光强,陈碧琼,等.人参皂苷Rbl对大鼠脑缺血再灌注JAK2/STAT3信号转导通路的影响[J].重庆医学,2013,42(17):1932-1934.
高龙龙,尹丽君,孟祎凡,等.麦冬及其有效成分抗心脑血管疾病的药理研究进展[J].中国中医药现代远程教育,2021,19(13):182-185.
王敏,张秋霞,邹海艳,等.竹节参总皂苷对慢性脑缺血大鼠海马GFAP、GAP-43表达的影响[J].世界中医药,2013,8(2):183-185.
杨璐平,刘方永,徐凯,等.穿山龙总皂苷对脑缺血损伤大鼠的保护作用[J].泰山医学院学报,2020,41(11):817-821.
王春燕,黄萍,张朕华.3β-双水杨酰薯蓣皂苷元对脑缺血/再灌注损伤大鼠的梗死体积及PI3K/Akt信号通路的影响[J].中国药理学通报,2013,29(12):1672-1675.
刘学红,潘阳,王剑波.太白楤木总皂苷对小鼠脑缺血/再灌注的脑保护作用机制[J].中国新药杂志,2019,28(11):1360-1365.
王爱华,王丽丽,刘英梅,等.西洋参茎叶总皂苷对大鼠局灶性脑缺血损伤及其炎症反应的影响[J].中南药学,2019,17(4):522-526.
吴非,郭胜蓝,程玉芳,等.知母总皂苷对大鼠脑缺血及再灌注损伤的保护作用[J].中国药学杂志,2006,41(9):668-671.
龚其海,谭丹枫,李菲,等.党参总皂苷对大鼠局灶性脑缺血性损伤的保护作用[J].中国新药与临床杂志,2011,30(5):339-342.
翟凤国,李厚忠,周福波,等.蒺藜皂苷对局灶性脑缺血大鼠脑组织PPARγ和NF-κB炎症信号途径表达的影响[J].医学综述,2015,21(24):4539-4540,4546.
李琳琳,冉新建,毛新民,等.胡芦巴总皂苷对脑缺血保护作用[J].中国药理学通报,2001,17(1):92-94.
张旭,李彬,高博闻,等.茅莓化学成分及药理活性研究[J].中医学报,2014,29(9):1332-1334.
刘金林,龙子江,张道福,等.无患子皂苷对脑缺血再灌注损伤模型大鼠炎症因子的影响[J].中医药临床杂志,2011,23(7):635-637.
曹光昭,徐核,张毅,等.灯盏生脉胶囊抗慢性脑缺血的分子作用机制分析[J].中国实验方剂学杂志,2022,28(7):49-56.
李艳,陈雨,杨柳,等.参附注射液治疗心脑血管疾病相关物质基础及作用机制研究进展[J].中药新药与临床药理,2019,30(4):499-503.
臧卫平,张志军,封倩,等.盐酸氟西汀联合三七通舒胶囊对缺血性脑卒中老年患者NIHSS评分及血清CGRP、IGF-1水平的影响[J].中国老年学杂志,2021,41(19):4178-4181.
袁庆,殷孟兰,赵磊,等.注射用血栓通对脑缺血损伤的药理研究现状[J].中国临床药理学杂志,2020,36(16):2521-2524.
任周新,李丽,李君,等.黄芪总皂苷和三七总皂苷配伍对大鼠局灶性脑缺血的影响[J].中国实验方剂学杂志,2006,12(12):56-58.
万凤,刘峻崎,田沫,等.黄芪甲苷、麦冬皂苷作用于大鼠星形胶质细胞和脑微血管内皮细胞对中风后神经干细胞增殖和分化的影响[J].中国民康医学,2015(14):174.
董利平,崔玉环,赵宝民,等.柴胡皂苷d联合黄芩苷对大鼠缺血/再灌注损伤中Th1/Th2平衡的影响[J].中国老年学杂志,2016,36(16):3918-3920.
杨先浩,陈涛.中药皂苷类成分抗肿瘤的作用机制[J].生命的化学,2020,40(8):1375-1381.
汪悦,邬颖华.中药皂苷类化合物治疗糖尿病肾病研究进展[J].亚太传统医药,2018,14(5):114-117.
吴朋,李银华,谭心海,等.桔梗总皂苷对支气管肺发育不良新生大鼠肺损伤的作用及机制研究[J].中国现代医学杂志,2022,32(5):52-57.
王新红,张迟,刘琳,等.皂苷类成分与肠道菌群相互作用研究进展[J].中成药,2021,43(7):1834-1839.
LI X,LI S,MA C,et al.Preparation of baicalin-loaded ligand-modified nanoparticles for nose-to-brain delivery for neuroprotection in cerebral ischemia[J].Drug Deliv,2022,29(1):1282-1298.
0
Views
15
下载量
1
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution