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Research Progress of Active Components of Traditional Chinese Medicine in Treatment of Hyperlipidemia by Activating PPAR
α Pathway- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 11, Pages: 247-254(2023)
- 作者机构：
江西中医药大学 院士工作站，南昌 330004
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20221903
CLC： R2-0;R22;R285.5;R284;R33Published：05 June 2023，
Published Online：18 October 2022，
Received：19 July 2022，
- 稿件说明：
扫 描 看 全 文
吴一冰,周小青,颜冬梅等.中药激活PPARα通路治疗高脂血症的活性成分及作用机制研究进展[J].中国实验方剂学杂志,2023,29(11):247-254.
WU Yibing,ZHOU Xiaoqing,YAN Dongmei,et al.Research Progress of Active Components of Traditional Chinese Medicine in Treatment of Hyperlipidemia by Activating PPARα Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(11):247-254.
吴一冰,周小青,颜冬梅等.中药激活PPARα通路治疗高脂血症的活性成分及作用机制研究进展[J].中国实验方剂学杂志,2023,29(11):247-254. DOI： 10.13422/j.cnki.syfjx.20221903.
WU Yibing,ZHOU Xiaoqing,YAN Dongmei,et al.Research Progress of Active Components of Traditional Chinese Medicine in Treatment of Hyperlipidemia by Activating PPARα Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(11):247-254. DOI： 10.13422/j.cnki.syfjx.20221903.
摘要
高脂血症是由血脂代谢紊乱引发的血脂异常疾病，可分为原发性和继发性2类，目前临床诊断标准主要为血脂水平变化，是动脉粥样硬化、胰腺炎、冠心病等高危心血管疾病的诱因。过氧化物酶体增殖物激活受体
α
（PPAR
α
）作为脂质代谢中承上启下的关键靶点，参与了包括脂肪酸降解、合成、运输、储存、脂蛋白代谢等多种代谢活动，激活PPAR
α
可通过多种方式维持脂代谢平衡，是治疗高脂血症的重要途径。目前临床上治疗高脂血症主要使用他汀类、贝特类等化学药物，虽然可以在一定程度上减缓病势，但不良反应多且存在耐药性。笔者通过查阅近几年文献总结发现，中药激活PPAR
α
通路治疗高脂血症效果显著且不良反应小，降脂活性成分包括黄酮类、生物碱类、酚类和萜类等多类型化合物，这些活性成分主要通过激活PPAR
α
通路影响下游效应因子表达进而抑制总胆固醇合成和促进脂肪酸氧化，发挥治疗高脂血症的作用。该文系统综述激活PPAR
α
通路的中药活性成分的结构类型及作用机制，为降脂中药新药的合理开发和临床应用提供指导。
Abstract
Hyperlipidemia is a dyslipidemia caused by dyslipidemia of lipid metabolism， which can be divided into primary and secondary types. The current clinical diagnostic criteria are mainly changes in lipid levels， which are the inducers of high-risk cardiovascular diseases such as atherosclerosis， pancreatitis and coronary heart disease. As a key target in lipid metabolism， peroxisome proliferator-activated receptor
α
（PPAR
α
） is involved in a variety of metabolic activities， including fatty acid degradation， synthesis， transport， storage， lipoprotein metabolism， etc. Activation of PPAR
α
can maintain the balance of lipid metabolism through a variety of ways， which is an important way to treat hyperlipidemia. At present， chemical drugs such as statins and bettes are mainly used in the clinical treatment of hyperlipidemia. Although they can slow down the disease to a certain extent， there are many adverse reactions and drug resistance. By reviewing the literature in recent years， the author found that the activation of PPAR
α
pathway by traditional Chinese medicine in the treatment of hyperlipidemia has significant effect and small adverse reactions. The lipid-lowering active ingredients include flavonoids， alkaloids， phenols， terpenoids and other compounds. These active components mainly affect the expression of downstream effectors through the activation of PPAR
α
pathway， thereby inhibiting the synthesis of total cholesterol and promoting fatty acid oxidation， and play a role in the treatment of hyperlipidemia. In this paper， we systematically reviewed the structure types and mechanism of active components of traditional Chinese medicine that activate PPAR
α
pathway， so as to provide guidance for the rational development and clinical application of lipid-lowering traditional Chinese medicine new drugs.
关键词
过氧化物酶体增殖物激活受体α（PPARα）高脂血症活性成分作用机制。
Keywords
peroxisome proliferator-activated receptor α （PPARα）hyperlipidemiaactive constituentmechanism of action
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