Mechanism of Huangqintang in Treatment of Ulcerative Colitis and Related Colon Cancer： A Review

FENG Xue; LIU Yaqing; LIU Bin; MA Xuran; WANG Dunfang; YANG Weipeng

doi:10.13422/j.cnki.syfjx.20222003

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Mechanism of Huangqintang in Treatment of Ulcerative Colitis and Related Colon Cancer： A Review

更新时间：2023-05-17

- Mechanism of Huangqintang in Treatment of Ulcerative Colitis and Related Colon Cancer： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 7, Pages: 1-10(2023)
- 作者机构：
  
  1.中国中医科学院中药研究所,北京 100700
  2.黑龙江中医药大学,哈尔滨 150040
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20222003
  CLC： R2-0;R22;R285.5;R284;R33
- Published：05 April 2023，
  
  Published Online：02 November 2022，
  
  Received：18 August 2022，
- 稿件说明：
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冯雪,刘雅清,刘滨等.黄芩汤治疗溃疡性结肠炎及相关结肠癌的机制研究进展[J].中国实验方剂学杂志,2023,29(07):1-10.

FENG Xue,LIU Yaqing,LIU Bin,et al.Mechanism of Huangqintang in Treatment of Ulcerative Colitis and Related Colon Cancer： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(07):1-10.
冯雪,刘雅清,刘滨等.黄芩汤治疗溃疡性结肠炎及相关结肠癌的机制研究进展[J].中国实验方剂学杂志,2023,29(07):1-10. DOI： 10.13422/j.cnki.syfjx.20222003.

FENG Xue,LIU Yaqing,LIU Bin,et al.Mechanism of Huangqintang in Treatment of Ulcerative Colitis and Related Colon Cancer： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(07):1-10. DOI： 10.13422/j.cnki.syfjx.20222003.

摘要

溃疡性结肠炎是一种病因尚不明确的慢性肠道疾病，主要症状为腹痛、腹泻、黏液脓血便等，并可伴有多种并发症，转化为结肠癌的风险较高。近年来溃疡性结肠炎和相关结肠癌的发病率有上升的趋势，严重影响人体健康和生活质量。手术和免疫抑制剂等是现代临床治疗溃疡性结肠炎和相关结肠癌的主要方法，但这些方法均有不同的不良反应，治疗效果不理想。多年来，中医药由于其不良反应小，疗效显著，在治疗溃疡性结肠炎和相关结肠癌方面备受关注。黄芩汤出自《伤寒论》，由黄芩、芍药、甘草和大枣组成，具有清热止利、和中止痛之功效，用于治疗溃疡性结肠炎疗效显著。黄芩汤成分复杂，以多靶点多途径发挥作用。经文献查阅并结合本课题组多年的研究成果，发现黄芩汤治疗溃疡性结肠炎和相关结肠癌的作用机制可能与保护肠黏膜屏障，抑制炎症反应，促进线粒体自噬，抑制氧化应激，调控肠道菌群、细胞周期、基因表达，抑制细胞增殖和促进细胞凋亡等多种机制相关。现将近年来的研究情况进行较为详尽的综述，以期能够为黄芩汤作用机制的深入研究及临床用药提供理论参考。

Abstract

Ulcerative colitis （UC） is a chronic intestinal disease with unknown etiology， with main symptoms of abdominal pain， diarrhea， mucus， pus， and blood in the stool. It can be accompanied by various complications and has a high risk of developing to colon cancer. In recent years， the incidence of UC and related colon cancer has been increasing， which seriously affects human health and quality of life. The operation， immunosuppressant， etc. are the main approaches in the modern clinical treatment of UC and related colon cancer， but these methods all have different toxic and side effects， and the therapeutic effect is not ideal. For many years， traditional Chinese medicine （TCM） has attracted much attention in the treatment of UC and related colon cancer due to its slightly toxic side effects and remarkable curative efficacy. Huangqintang， derived from the

Shang Han Lun

（伤寒论）， is composed of Scutellariae Radix， Paeoniae Radix Alba， Glycyrrhizae Radix et Rhizoma， and Jujubae Fructus

with the functions of clearing heat， checking diarrhea， harmonizing the middle， and relieving pain， and has a significant effect on the treatment of UC. Huangqintang has complex compositions and plays roles with multiple targets and pathways. According to the literature and the research results of this research group for many years， it was found that the mechanism of Huangqintang in the treatment of UC and related colon cancer was presumably related to the protection of the intestinal mucosal barrier， inhibition of inflammatory response， promotion of mitophagy， inhibition of oxidative stress， regulation of intestinal flora， cell cycle， and gene expression， suppression of cell proliferation， and promotion of apoptosis. To provide theoretical references for an in-depth study of the mechanism and clinical use of Huangqintang， this paper reviewed the research advances in recent years.

关键词

溃疡性结肠炎结肠癌黄芩汤机制

Keywords

ulcerative colitiscolon cancerHuangqintangmechanism

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