Chinese Medicine Intervention in Diabetic Cardiomyopathy Based on Autophagy：A Review

YU Yunfeng; HU Gang; ZHOU Manli; ZHOU Xiahui; ZHAO Yanzhen; JIAN Weixiong

doi:10.13422/j.cnki.syfjx.20222399

您当前的位置：

首页 >

文章列表页 >

Chinese Medicine Intervention in Diabetic Cardiomyopathy Based on Autophagy：A Review

更新时间：2023-10-20

- Chinese Medicine Intervention in Diabetic Cardiomyopathy Based on Autophagy：A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 22, Pages: 276-282(2023)
- 作者机构：
  
  1.湖南中医药大学中医学院，长沙 410208
  2.湖南中医药大学第一附属医院，长沙 410007
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20222399
  CLC： R2-0;R22;R285.5;R2-031;R259;R587.1;R542.2
- Published：20 November 2023，
  
  Published Online：30 August 2022，
  
  Received：04 May 2022，
- 稿件说明：
扫描看全文
俞赟丰,胡港,周曼丽等.基于自噬机制的中医药干预糖尿病心肌病的研究进展[J].中国实验方剂学杂志,2023,29(22):276-282.

YU Yunfeng,HU Gang,ZHOU Manli,et al.Chinese Medicine Intervention in Diabetic Cardiomyopathy Based on Autophagy：A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(22):276-282.
俞赟丰,胡港,周曼丽等.基于自噬机制的中医药干预糖尿病心肌病的研究进展[J].中国实验方剂学杂志,2023,29(22):276-282. DOI： 10.13422/j.cnki.syfjx.20222399.

YU Yunfeng,HU Gang,ZHOU Manli,et al.Chinese Medicine Intervention in Diabetic Cardiomyopathy Based on Autophagy：A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(22):276-282. DOI： 10.13422/j.cnki.syfjx.20222399.

摘要

自噬是一种细胞内溶酶体分解代谢的过程，也是糖尿病心肌病（DCM）发病的重要机制。自噬对DCM具有双向调节作用，在生理状态下，正常水平的自噬可促进受损心肌细胞及代谢产物的正常分解，从而减少有害物质对机体的损害，同时为心肌细胞提供能量。在病理状态下，心肌细胞的自噬过度抑制会引起受损细胞和代谢产物的不断蓄积，而受损细胞及代谢产物会对心肌细胞造成损害，最终加剧DCM患者的心功能障碍。而心肌细胞的自噬过度激活会导致大量心肌细胞自噬性死亡，引发心肌病理性重构和心功能障碍，从而导致DCM进展加重。因此，恢复正常自噬水平是保护心肌细胞和改善DCM预后的关键手段。中医药可通过干预自噬来发挥治疗DCM的作用，其作用效果可概括为促进细胞自噬（补其不足）和抑制细胞自噬（损其有余）2个方面，最终使自噬微环境恢复平衡，自噬强度调整到最佳水平，DCM渐趋缓解。

Abstract

Autophagy is a lysosome-dependent intracellular degradation process，and it is a key mechanism of diabetic cardiomyopathy （DCM）. Autophagy has dual regulatory effects on DCM. Under physiological conditions，normal autophagy can promote the decomposition of damaged cardiomyocytes and metabolites，so as to reduce the damage of harmful substances to the body and provide energy for cardiomyocytes. Under pathological conditions，the inhibited autophagy of cardiomyocytes will cause the accumulation of damaged cells and metabolites，which will cause damage to cardiomyocytes and eventually aggravate cardiac dysfunction in the patients with DCM. However，the over autophagy of cardiomyocytes will lead to autophagic death of a large number of cardiomyocytes and result in pathological myocardial remodeling and cardiac dysfunction，thus promoting the progression of DCM. Therefore，the restoration of a normal autophagy level is the key means to protect cardiomyocytes and improve the prognosis of DCM. Chinese medicine can regulate autophagy to treat DCM. Specifically，it can promote autophagy （making up for deficiency） or inhibit autophagy （removing excess） to restore the balance of autophagy，thereby alleviating DCM.

关键词

自噬糖尿病心肌病中医药研究进展

Keywords

autophagydiabetic cardiomyopathyChinese medicineresearch progress

references

GRUBIĆ ROTKVIĆ P，PLANINIĆ Z，LIBERATI PRŠO A M，et al. The mystery of diabetic cardiomyopathy：From early concepts and underlying mechanisms to novel therapeutic possibilities［J］. Int J Mol Sci，2021，22（11）：5973.

JIA G，WHALEY-CONNELL A，SOWERS J R. Diabetic cardiomyopathy：A hyperglycaemia and insulin resistance induced heart disease［J］. Diabetologia，2018，61（1）：21-28.

佟红娜，张晨阳，韩美欣.糖尿病心肌病的发病机制及药物干预研究进展［J］.中国实验方剂学杂志，2022，28（2）：257-265.

SUN X，CHEN R，YANG Z，et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis［J］. Food Chem Toxico，2014，63：221-232.

刘婷婷.自噬与糖尿病心肌病关系的研究进展［J］.山东医药，2018，58（1）：102-105.

位晨晨，钟明.糖尿病心肌病的发病机制［J］.心血管病学进展，2020，41（2）：135-139.

李帅，鲍翠玉，李晶.自噬相关通路在糖尿病心肌病中的研究进展［J］.中国药理学通报，2019，35（6）：753-756.

TAN Y，ZHANG Z，ZHENG C，et al. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies：Preclinical and clinical evidence［J］. Nat Rev Cardio，2020，17（9）：585-607.

吕超，马治，朱峰.中药有效成分治疗糖尿病心肌病的研究进展［J］.医学综述，2022（8）：1591-1597.

SHIRAKABE A，IKEDA Y，SCIARRETTA S，et al. Aging and autophagy in the heart［J］. Circ Res，2016，118（10）：1563-1576.

ZAHOOR M，FARHAN H. Crosstalk of autophagy and the secretory pathway and its role in diseases［J］. Int Rev Cell Mol Biol，2018，337：153-184.

DEWANJEE S，VALLAMKONDU J，KALRA R S，et al. Autophagy in the diabetic heart：A potential pharmacotherapeutic target in diabetic cardiomyopathy［J］. Ageing Res Rev，2021，68：101338.

LEVINE B，KROEMER G. Biological functions of autophagy genes：A disease perspective［J］. Cell，2019，176（1/2）：11-42.

QIN C，LU Y，BAI L，et al. The molecular regulation of autophagy in antimicrobial immunity［J］. J Mol Cell Biol，2022，doi： 10.1093/jmcb/mjac015http://dx.doi.org/10.1093/jmcb/mjac015.

CAO W，LI J，YANG K，et al. An overview of autophagy：Mechanism，regulation and research progress［J］. Bull Cancer，2021，108（3）：304-322.

NISHIDA K，TANEIKE M，OTSU K. The role of autophagic degradation in the heart［J］. J Mol Cell Cardiol，2015，78：73-79.

KAUR N，RAJA R，RUIZ-VELASCO A，et al. Cellular protein quality control in diabetic cardiomyopathy：From bench to bedside［J］. Front Cardiovasc Med，2020，doi：10.3389/fcvm.2020.585309http://dx.doi.org/10.3389/fcvm.2020.585309.

连燚沛，金海群，王旭.氧化还原稳态与自噬在糖尿病心肌病中的研究进展［J］.中国医药生物技术，2019，14（5）：449-452.

LI X，BAI C，WANG H，et al. LncRNA MEG3 regulates autophagy and pyroptosis via FOXO1 in pancreatic β-cells［J］. Cell Signal，2022，92：110247.

CHEN D，ZHANG M. GAS5 regulates diabetic cardiomyopathy via miR‑221‑3p/p27 axis‑associated autophagy［J］. Mol Med Rep，2021，23（2）：135.

YANG F，QIN Y，WANG Y，et al. Metformin inhibits the NLRP3 inflammasome via AMPK/mTOR-dependent effects in diabetic cardiomyopathy［J］. Int J Biol Sci，2019，15（5）：1010-1019.

LIN C，ZHANG M，ZHANG Y，et al. Helix B surface peptide attenuates diabetic cardiomyopathy via AMPK-dependent autophagy［J］. Biochem Biophys Res Commun，2017，482（4）：665-671.

TUOHETAERBAIKE B，ZHANG Y，TIAN Y，et al. Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and Akt/mTOR signaling pathway［J］. J Ethnopharmacol，2020，250：112479.

GUO X，LIN H，LIU J，et al. 1，25-Dihydroxyvitamin D attenuates diabetic cardiac autophagy and damage by vitamin D receptor-mediated suppression of FoxO1 translocation［J］.J Nutr Biochem，2020，80：108380.

FENG Y，XU W，ZHANG W，et al. LncRNA DCRF regulates cardiomyocyte autophagy by targeting miR-551b-5p in diabetic cardiomyopathy［J］. Theranostics，2019，9（15）：4558.

CHEN C，YANG S，LI H，et al. Mir30c is involved in diabetic cardiomyopathy through regulation of cardiac autophagy via BECN1［J］. Mol Ther Nucleic Acids，2017，7：127-139.

KANAMORI H，NARUSE G，YOSHIDA A，et al. Morphological characteristics in diabetic cardiomyopathy associated with autophagy［J］. J Cardiol，2021，77（1）：30-40.

王志丹，贾连群，宋囡.从阴阳自和角度论肝脏脂质代谢与细胞自噬的关系［J］.时珍国医国药，2017，28（4）：924-925.

孟鑫，李颖，安铭立.从中医阴阳理论探讨细胞自噬与子宫内膜异位症肾阳虚血瘀病机的关系［J］.河北中医药学报，2021，36（6）：5-8.

许文婷，杨佩颖，贾英杰.从中医角度论细胞自噬［J］.四川中医，2015，33（5）：34-35.

XU K，LIU X，KE Z，et al. Resveratrol modulates apoptosis and autophagy induced by high glucose and palmitate in cardiac cells［J］. Cell Physiol Biochem，2018，46（5）：2031-2040.

WANG G Y，BI Y G，LIU X D，et al. Upregulation of connexin 43 and apoptosis‑associated protein expression by high glucose in H9c2 cells was improved by resveratrol via the autophagy signaling pathway［J］. Mol Med Rep，2017，16（3）：3262-3268.

FEIDANTSIS K，MELLIDIS K，GALATOU E，et al. Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy［J］. Nutr Metab Cardiovasc Dis，2018，28（9）：952-961.

叶婷，马国庆，魏明慧，等.黄芪多糖对糖尿病心肌病大鼠AMPK-mTOR通路的调控机制研究［J］.世界中医药，2022，17（7）：977-982.

YAO Q，KE Z，GUO S，et al. Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis［J］. J Mol Cell Cardiol，2018，124：26-34.

胡鹏飞，陆明，杨明.炙甘草汤对糖尿病性心肌病模型大鼠心功能的影响［J］.浙江中西医结合杂志，2020，30（6）：444-448.

马振旺，姜德友，袁星星.白藜芦醇通过Mst1/Sirt3信号通路介导的细胞自噬改善糖尿病心肌损伤的机制研究［J］.海南医学院学报，2022，28（4）：251-257.

魏东明，徐臣年，刘洋.积雪草苷通过Notch1/Hes1信号上调自噬减轻糖尿病心肌病心肌损伤的作用及机制［J］.山西医科大学学报，2022，53（3）：305-311.

LIANG R K，ZHAO Y Y，SHI M L，et al. Skimmin protects diabetic cardiomyopathy in streptozotocin‐induced diabetic rats［J］. Kaohsiung J Med Sci，2021，37（2）：136-144.

LIU Y，WU S，ZHAO Q，et al. Trehalose Ameliorates Diabetic Cardiomyopathy：Role of the PK2/PKR Pathway［J］. Oxid Med Cell Longev，2021，2021：6779559.

叶婷，陈晶，马国庆.黄芪多糖对糖尿病心肌病大鼠自噬的调控机制研究［J］.时珍国医国药，2022，33（2）：312-316.

孙波，张晓晓，刘廪.齐墩果酸对糖尿病大鼠心肌保护作用及机制研究［J］.中华急诊医学杂志，2020，29（9）：1191-1195.

ZHOU H，CHEN Y，HUANG S，et al. Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy［J］. J Zhejiang Univ Sci B，2018，19（5）：333-341.

ZHU Y，QIAN X，LI J，et al. Astragaloside-Ⅳ protects H9C2（2-1） cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway［J］. Artif Cells Nanomed Biotechnol，2019，47（1）：4172-4181.

SONG R，ZHAO X，CAO R，et al. Irisin improves insulin resistance by inhibiting autophagy through the PI3K/Akt pathway in H9c2 cells［J］. Gene，2021，769：145209.

吴冰，张莲，郭烽.淫羊藿苷通过AMPK/mTOR信号抑制自噬减轻糖尿病心肌肥厚研究［J］.海南医学院学报，2021，27（20）：1547-1551.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Traditional Chinese Medicine Treats Ischemic Stroke by Regulating mTOR Signaling Pathway： A Review

Research Progress on Dual Role of Autophagy in Cancer and Intervention of Traditional Chinese Medicine

Traditional Chinese Medicine Regulates Autophagy to Prevent and Treat Osteoarthritis： A Review

Chinese Medicine Regulates NLRP3 Inflammasomes to Treat Diabetic Nephropathy： A Review

Related Author

MA Yugang

WANG Xingchen

WANG Xuebin

LI Yahui

MA Yugang

WANG Xingchen

WANG Xuebin

LI Yahui

Related Institution

Shandong University of Traditional Chinese Medicine(TCM)

The Second Affiliated Hospital of Shandong University of TCM

Shandong University of Traditional Chinese Medicine

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Henan University of Chinese Medicine

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰