浏览全部资源
扫码关注微信
Autophagy Regulated by Chinese Medicine Monomers in Embryo Implantation： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 4, Pages: 253-262(2023)
- 作者机构：
1.山东中医药大学，济南 250014
2.山东中医药大学 附属医院，济南 250011
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20230112
CLC： R714.12;R285;R289;R22;R2-031;R33Published：20 February 2023，
Published Online：28 November 2022，
Received：16 September 2022，
- 稿件说明：
扫 描 看 全 文
周芷聿,师伟.中药单体调控自噬干预胚胎植入的研究进展[J].中国实验方剂学杂志,2023,29(04):253-262.
ZHOU Zhiyu,SHI Wei.Autophagy Regulated by Chinese Medicine Monomers in Embryo Implantation： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(04):253-262.
周芷聿,师伟.中药单体调控自噬干预胚胎植入的研究进展[J].中国实验方剂学杂志,2023,29(04):253-262. DOI： 10.13422/j.cnki.syfjx.20230112.
ZHOU Zhiyu,SHI Wei.Autophagy Regulated by Chinese Medicine Monomers in Embryo Implantation： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(04):253-262. DOI： 10.13422/j.cnki.syfjx.20230112.
摘要
胚胎植入是生殖过程中最关键的步骤之一，植入失败的胚胎无法继续发育，是导致不孕的重要原因之一。胚胎植入的成功依赖于子宫内膜的高容受性和具有植入能力的胚胎。自噬是细胞质、细胞器和内含物被双膜囊泡吸收并运输到溶酶体进行降解和再循环的过程，是一种维持内环境稳态的方式。大量证据表明，自噬在胚胎植入的各个环节有着重要的作用。基于此探讨了自噬与子宫内膜容受性和胚胎植入能力的关系，并根据最新的研究进展，梳理了大黄素、梓醇、芍药苷、白藜芦醇、叶酸、玉米赤霉烯酮、姜黄素、汉黄芩素、槲皮素、白杨素、小檗碱、芹菜素、菲西汀、山柰酚在内的14种中药单体调控自噬干预胚胎植入的不同环节的5个机制，包括促进子宫内膜基质细胞蜕膜化、促进细胞凋亡、调节激素水平、协调炎症、促进排卵，希望对今后中药单体提高胚胎植入的成功率提供参考及思路。
Abstract
Embryo implantation is one of the most critical steps in the reproductive process. The failure of embryo implantation to continue development is one of the important reasons leading to infertility. The success of embryo implantation depends on the high receptivity of endometrium and the embryo with implantation ability. Autophagy is a process in which cytoplasm， organelles， and inclusions are absorbed by double-membrane vesicles and transported to lysosomes for degradation and recycling， which is a way to maintain the homeostasis. A large amount of evidence have shown that autophagy plays an important role in all aspects of embryo implantation. Based on this， this paper explored the relationship between autophagy and endometrial receptivity and embryo implantation ability. According to the latest research progress， this paper combed 5 mechanisms （promotion of decidualization of endometrial stromal cells， promotion of apoptosis， regulation of hormone levels， coordination of inflammation， and promotion of ovulation） of 14 kinds of Chinese medicine monomers， including emodin， catalpol， paeoniflorin， resveratrol， folic acid， zearalenone， curcumin， wogonin， quercetin， chrysin， berberine， apigenin， phisetine， and kaempferol， in regulating different links of autophagy intervention in embryo implantation. This paper is expected to provide references and ideas for future Chinese medicine monomers to improve the success rate of embryo implantation.
关键词
胚胎植入自噬中药单体影响机制综述
Keywords
embryo implantationautophagyChinese medicine monomersinfluence mechanismreview
references
MROZIKIEWICZ A E，OŻAROWSKI M，JĘDRZEJCZAK P.Biomolecular markers of recurrent implantation failure-a review［J］.Int J Mol Sci，2021，22（18）
BAUERSACHS S，WOLF E.Uterine responses to the preattachment embryo in domestic ungulates： Recognition of pregnancy and preparation for implantation［J］.Annu Rev Anim Biosci，2015，3：489-511.
MIRAVET-VALENCIANO J A，RINCON-BERTOLIN A，VILELLA F，et al.Understanding and improving endometrial receptivity［J］.Curr Opin Obstet Gynecol，2015，27（3）：187-192.
BELLVER J，SIMÓN C.Implantation failure of endometrial origin： What is new？［J］.Curr Opin Obstet Gynecol，2018，30（4）：229-236.
KIM S M，KIM J S.A Review of mechanisms of implantation［J］.Dev Reprod，2017，21（4）：351-359.
KHAN R N，HAMOUD H，WARREN A，et al.Relaxant action of sildenafil citrate （Viagra） on human myometrium of pregnancy［J］.Am J Obstet Gynecol，2004，191（1）：315-321.
VALDES C T，SCHUTT A，SIMON C.Implantation failure of endometrial origin：It is not pathology， but our failure to synchronize the developing embryo with a receptive endometrium［J］.Fertil Steril，2017，108（1）：15-18.
BINDER N K，EVANS J，GARDNER D K，et al.Endometrial signals improve embryo outcome： Functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice［J］.Hum Reprod，2014，29（10）：2278-2286.
YANG J H，CHEN C D，CHOU C H，et al.Intentional endometrial injury increases embryo implantation potentials through enhanced endometrial angiogenesis†［J］.Biol Reprod，2019，100（2）：381-389.
SHAULOV T，SIERRA S，SYLVESTRE C.Recurrent implantation failure in IVF： A canadian fertility and andrology society clinical practice guideline［J］.Reprod Biomed Online，2020，41（5）：819-833.
BUSNELLI A，SOMIGLIANA E，CIRILLO F，et al.Efficacy of therapies and interventions for repeated embryo implantation failure： A systematic review and meta-analysis［J］.Sci Rep，2021，11（1）：1747.
CECCHINO G N，GARCÍA-VELASCO J A.Endometrioma，fertility， and assisted reproductive treatments：Connecting the dots［J］.Curr Opin Obstet Gynecol，2018，30（4）：223-228.
MA Y，CAO X，SONG J，et al.Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis： Study protocol for a prospective， multicenter， randomized double-blind study［J］.Trials，2021，22（1）：917.
TANG X，CHEN J，OU P，et al.Chinese herbal compound prescription for Endometriosis：A protocol for systematic review and Meta-analysis［J］.Medicine （Baltimore），2020，99（42）：e22698.
ZHANG Y，GAO R，ZHANG L，et al.AMPK/mTOR downregulated autophagy enhances aberrant endometrial decidualization in folate-deficient pregnant mice［J］.J Cell Physiol，2021，236（11）：7376-7389.
KONRAD L，KORTUM J，NABHAM R，et al.Composition of the stroma in the human endometrium and endometriosis［J］.Reprod Sci，2018，25（7）：1106-1115.
AMĂLINEI C，PĂVĂLEANU I，GRIGORAŞ A，et al.The endometrial regeneration frontiers： From mechanisms to applications in regenerative medicine［J］.Rom J Morphol Embryol，2018，59（2）：407-425.
VALENTIJN A J，PALIAL K，AL-LAMEE H，et al.SSEA-1 isolates human endometrial basal glandular epithelial cells： Phenotypic and functional characterization and implications in the pathogenesis of endometriosis［J］.Hum Reprod，2013，28（10）：2695-2708.
CHOI J，JO M，LEE E，et al.The role of autophagy in human endometrium［J］.Biol Reprod，2012，86（3）：70.
SU Y，ZHANG J J，HE J L，et al.Endometrial autophagy is essential for embryo implantation during early pregnancy［J］.J Mol Med （Berl），2020，98（4）：555-567.
LAMB C A，YOSHIMORI T，TOOZE S A.The autophagosome：Origins unknown， biogenesis complex［J］.Nat Rev Mol Cell Biol，2013，14（12）：759-774.
ICHIMURA Y，KIRISAKO T，TAKAO T，et al.A ubiquitin-like system mediates protein lipidation［J］.Nature，2000，408（6811）：488-492.
TANIDA I，MINEMATSU-IKEGUCHI N，UENO T，et al.Lysosomal turnover，but not a cellular level，of endogenous LC3 is a marker for autophagy［J］.Autophagy，2005，1（2）：84-91.
OESTREICH A K，CHADCHAN S B，MEDVEDEVA A，et al.The autophagy protein，FIP200 （RB1CC1） mediates progesterone responses governing uterine receptivity and decidualization［J］.Biol Reprod，2020，102（4）：843-851.
CHOI J，JO M，LEE E，et al.Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts［J］.Mol Hum Reprod，2014，20（4）：309-317.
YADAV P K，TIWARI M，GUPTA A，et al.Germ cell depletion from mammalian ovary：Possible involvement of apoptosis and autophagy［J］.J Biomed Sci，2018，25（1）：36.
RAMATHAL C Y，BAGCHI I C，TAYLOR R N，et al.Endometrial decidualization： Of mice and men［J］.Semin Reprod Med，2010，28（1）：17-26.
GELLERSEN B，BROSENS J J.Cyclic decidualization of the human endometrium in reproductive health and failure［J］.Endocr Rev，2014，35（6）：851-905.
MESTRE CITRINOVITZ A C，STROWITZKI T，GERMEYER A.Decreased autophagy impairs decidualization of human endometrial stromal cells： A role for ATG proteins in endometrial physiology［J］.Int J Mol Sci，2019，20（12）：23-28.
AVAGLIANO L，TERRANEO L，VIRGILI E，et al.Autophagy in Normal and Abnormal Early Human Pregnancies［J］.Reprod Sci，2015，22（7）：838-844.
ZHENG Q，LI S，LI X，et al.Advances in the study of emodin： An update on pharmacological properties and mechanistic basis［J］.Chin Med，2021，16（1）：102.
ZHENG Q，XU Y，LU J，et al.Emodin inhibits migration and invasion of human endometrial stromal cells by facilitating the mesenchymal-epithelial transition through targeting ILK［J］.Reprod Sci，2016，23（11）：1526-1535.
CHANG M H，HUANG F J，CHAN W H.Emodin induces embryonic toxicity in mouse blastocysts through apoptosis［J］.Toxicology，2012，299（1）：25-32.
PYO J O，NAH J，JUNG Y K.Molecules and their functions in autophagy［J］.Exp Mol Med，2012，44（2）：73-80.
REN H，WANG D，ZHANG L，et al.Catalpol induces autophagy and attenuates liver steatosis in ob/ob and high-fat diet-induced obese mice［J］.Aging （Albany NY），2019，11（21）：9461-9477.
WEI M，LU Y，LIU D，et al.Ovarian failure-resistant effects of catalpol in aged female rats［J］.Biol Pharm Bull，2014，37（9）：1444-1449.
SALLEH N，GIRIBABU N.Leukemia inhibitory factor：Roles in embryo implantation and in nonhormonal contraception［J］.Sci World J，2014，2014：201514.
ROSARIO G X，STEWART C L.The multifaceted actions of leukaemia inhibitory factor in mediating uterine receptivity and embryo implantation［J］.Am J Reprod Immunol，2016，75（3）：246-255.
PARK H R，CHOI H J，KIM B S，et al.Paeoniflorin enhances endometrial receptivity through leukemia inhibitory factor［J］.Biomolecules，2021，11（3）：113-119.
KURODA K，OCHIAI A，BROSENS J J.The actions of resveratrol in decidualizing endometrium： acceleration or inhibition？［J］.Biol Reprod，2020，103（6）：1152-1156.
OCHIAI A，KURODA K，IKEMOTO Y，et al.Influence of resveratrol supplementation on IVF-embryo transfer cycle outcomes［J］.Reprod Biomed Online，2019，39（2）：205-210.
MONSIVAIS D，CLEMENTI C，PENG J，et al.Uterine ALK3 is essential during the window of implantation［J］.Proc Natl Acad Sci U S A，2016，113（3）：E387-E395.
SHINDOH H，OKADA H，TSUZUKI T，et al.Requirement of heart and neural crest derivatives-expressed transcript 2 during decidualization of human endometrial stromal cells in vitro［J］.Fertil Steril，2014，101（6）：1781-1790.
SHI H C，YANG L L.Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle［J］.Pharm Biol，2012，50（6）：760-765.
MA W G，SONG H，DAS S K，et al.Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation［J］.Proc Natl Acad Sci U S A，2003，100（5）：2963-2968.
ZHANG S，KONG S，WANG B，et al.Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms［J］.Cell Res，2014，24（8）：925-942.
DENG L，SONG D，GUO J，et al.Study on ingredients of Scutellaria Radix extract penetrable through placental barrier of pregnant rat［J］.Zhongguo Zhong Yao Za Zhi，2012，37（3）：327-330.
BOLOUKI A，ZAL F，MOSTAFAVI-POUR Z，et al.Protective effects of quercetin on uterine receptivity markers and blastocyst implantation rate in diabetic pregnant mice［J］.Taiwan J Obstet Gynecol，2020，59（6）：927-934.
SHAHZAD H，GIRIBABU N，KARIM K，et al.Quercetin interferes with the fluid volume and receptivity development of the uterus in rats during the peri-implantation period［J］.Reprod Toxicol，2017，71：42-54.
CRITCHLEY H O，JONES R L，LEA R G，et al.Role of inflammatory mediators in human endometrium during progesterone withdrawal and early pregnancy［J］.J Clin Endocrinol Metab，1999，84（1）：240-248.
VERCELLINI P，VIGANÒ P，SOMIGLIANA E，et al.Endometriosis：Pathogenesis and treatment［J］.Nat Rev Endocrinol，2014，10（5）：261-275.
WINGFIELD M，MACPHERSON A，HEALY D L，et al.Cell proliferation is increased in the endometrium of women with endometriosis［J］.Fertil Steril，1995，64（2）：340-346.
HONDA H，BARRUETO F F，GOGUSEV J，et al.Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis［J］.Reprod Biol Endocrinol，2008，6：59.
AZAMI S H，NAZARIAN H，ABDOLLAHIFAR M A，et al.The antioxidant curcumin postpones ovarian aging in young and middle-aged mice［J］.Reprod Fertil Dev，2020，32（3）：292-303.
DEVI Y S，DEVINE M，DEKUIPER J，et al.Inhibition of IL-6 signaling pathway by curcumin in uterine decidual cells［J］.PLoS One，2015，10（5）：e0125627.
POLLARD J W，PACEY J，CHENG S V，et al.Estrogens and cell death in murine uterine luminal epithelium［J］.Cell Tissue Res，1987，249（3）：533-540.
TAN J，RAJA S，DAVIS M K，et al.Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation［J］.Mech Dev，2002，111（1/2）：99-113.
AKCALI K C，KHAN S A，MOULTON B C.Effect of decidualization on the expression of bax and Bcl-2 in the rat uterine endometrium［J］.Endocrinology，1996，137（7）：3123-3131.
LIAO X G，LI Y L，GAO R F，et al.Folate deficiency decreases apoptosis of endometrium decidual cells in pregnant mice via the mitochondrial pathway［J］.Nutrients，2015，7（3）：1916-1932.
CHEN Q，GAO R，GENG Y，et al.Decreased autophagy was implicated in the decreased apoptosis during decidualization in early pregnant mice［J］.J Mol Histol，2018，49（6）：589-597.
LI Y，GAO R，LIU X，et al.Folate deficiency could restrain decidual angiogenesis in pregnant mice［J］.Nutrients，2015，7（8）：6425-6445.
WU L，DUAN Q，GAO D，et al.Zearalenone blocks autophagy flow and induces cell apoptosis during embryo implantation in gilts［J］.Toxicol Sci，2020，175（1）：126-139.
PAN L Z，CHENG H，ZHANG J，et al.Invivo zearalenone exposure dose-dependently compromises mouse oocyte competence by impairing chromatin configuration and gene transcription［J］.Reprod Fertil Dev，2021，33（3）：229-238.
YIN N，WU C，QIU J，et al.Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+ CD28- T cells［J］.Stem Cell Res Ther，2020，11（1）：49.
MELEKOGLU R，CIFTCI O，ERASLAN S，et al.The protective effects of glycyrrhetinic acid and chrysin against ischemia-reperfusion injury in rat ovaries［J］.Biomed Res Int，2018，2018：5421308.
HUANG C H，WANG F T，CHAN W H.Dose-dependent beneficial and harmful effects of berberine on mouse oocyte maturation and fertilization and fetal development［J］.Toxicol Res （Camb），2020，9（4）：431-443.
EHTESHAMFAR S M，AKHBARI M，AFSHARI J T，et al.Anti-inflammatory and immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation［J］.J Cell Mol Med，2020，24（23）：13573-13588.
TALEBI A，HAYATI ROODBARI N，REZA SAMENI H，et al.Impact of coadministration of apigenin and bone marrow stromal cells on damaged ovaries due to chemotherapy in rat：An experimental study［J］.Int J Reprod Biomed，2020，18（7）：551-560.
SAFARI M，PARSAIE H，SAMENI H R，et al.Anti-oxidative and anti-apoptotic effects of apigenin on number of viable and apoptotic blastomeres，zona pellucida thickness and hatching rate of mouse embryos［J］.Int J Fertil Steril，2018，12（3）：257-262.
MIHANFAR A，NOURI M，ROSHANGAR L，et al.Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome［J］.J Steroid Biochem Mol Biol，2021，213：105954.
LI Y，LIU Y，CHEN J，et al.Protective effect of fisetin on the lipopolysaccharide-induced preeclampsia-like rats［J］.Hypertens Pregnancy，2022，41（1）：23-30.
SANTOS J，LINS T，BARBERINO R S，et al.Kaempferol promotes primordial follicle activation through the phosphatidylinositol 3-kinase/protein kinase B signaling pathway and reduces DNA fragmentation of sheep preantral follicles cultured in vitro［J］.Mol Reprod Dev，2019，86（3）：319-329.
CRUZ L L，FERREIRA SILVA B S，ARAUJO G G，et al.Phytochemical and antidiabetic analysis of Curatella americana L. aqueous extract on the rat pregnancy［J］.J Ethnopharmacol，2022，293：115287.
0
Views
15
下载量
3
CSCD
- H-PDFDownload
- L-PDFDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Postal code：100700
- Tel：010-84076882 Email：syfjx_2010@188.com
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
