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Active Components of Chinese Medicine Against Liver Fibrosis Based on PI3K/Akt Signaling Pathway： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 13, Pages: 230-240(2023)
- 作者机构：
1.河南中医药大学，郑州 450046
2.河南中医药大学 第一附属医院，郑州 450000
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20230202
CLC： R2-0;R22;R285.5;R284;R33Published：05 July 2023，
Published Online：05 January 2023，
Received：13 September 2022，
- 稿件说明：
扫 描 看 全 文
杨星,王振,李淑娣等.基于PI3K/Akt信号通路探讨中药活性成分抗肝纤维化的研究现状[J].中国实验方剂学杂志,2023,29(13):230-240.
YANG Xing,WANG Zhen,LI Shudi,et al.Active Components of Chinese Medicine Against Liver Fibrosis Based on PI3K/Akt Signaling Pathway： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(13):230-240.
杨星,王振,李淑娣等.基于PI3K/Akt信号通路探讨中药活性成分抗肝纤维化的研究现状[J].中国实验方剂学杂志,2023,29(13):230-240. DOI： 10.13422/j.cnki.syfjx.20230202.
YANG Xing,WANG Zhen,LI Shudi,et al.Active Components of Chinese Medicine Against Liver Fibrosis Based on PI3K/Akt Signaling Pathway： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(13):230-240. DOI： 10.13422/j.cnki.syfjx.20230202.
摘要
肝纤维化是肝脏对慢性损伤的一种病理性修复反应，是慢性肝病进展的关键环节，主要以肝星状细胞活化与细胞外基质弥漫性沉积为主要特征。目前临床上尚无理想的治疗肝纤维化的特效药物。近年来，随着中医药抗肝纤维化的发展和进步，中医药以其治疗效果明显，不良反应少等优势受到了广泛的关注。磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）信号通路是影响肝纤维化形成与发展重要的信号通路，其主要通过抑制肝星状细胞的活化与增殖、促进肝星状细胞的凋亡、减轻肝细胞氧化应激、减少细胞外基质沉积及增强肝细胞自噬等发面发挥肝纤维化效应。该文通过梳理中药单体靶向调控PI3K/Akt信号通路，总结中药单体调控PI3K/Akt发挥肝纤维化的作用机制及与其他信号通路的相互协同作用，以期为中医药治疗肝纤维化和临床新药研发给予一定的理论依据与参考。
Abstract
Hepatic fibrosis is a pathological reparative response of the liver to chronic injury and a crucial step in the progression of chronic liver disease， characterized mainly by the activation of hepatic stellate cells and diffuse deposition of extracellular matrix. Currently， there is no ideal specific drug for the treatment of liver fibrosis in clinical practice. In recent years， with the development and progress of traditional Chinese medicine （TCM） in the treatment of liver fibrosis， TCM has been widely recognized for its significant therapeutic effect and fewer adverse reactions. The phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway is an important pathway that affects the formation and development of liver fibrosis. It mainly plays a role in liver fibrosis by inhibiting the activation and proliferation of hepatic stellate cells， promoting their apoptosis， reducing oxidative stress in liver cells， decreasing the deposition of extracellular matrix， and enhancing liver cell autophagy. This article summarized the mechanisms by which Chinese medicinal monomers regulated the PI3K/Akt pathway to exert their effects on liver fibrosis and their synergistic effects with other signaling pathways， providing a theoretical basis and references for the development of new drugs for the treatment of liver fibrosis with TCM.
关键词
中药单体磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）信号通路肝纤维化肝星状细胞
Keywords
Chinese medicinal monomerphosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）signaling pathwayliver fibrosishepatic stellate cells
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