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长春中医药大学,长春 130117
Published:20 May 2023,
Published Online:20 January 2023,
Received:26 September 2022,
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冯晨曦,殷澳,侯相竹等.中药多糖治疗骨质疏松症和骨关节炎作用机制的研究进展[J].中国实验方剂学杂志,2023,29(10):264-273.
FENG Chenxi,YIN Ao,HOU Xiangzhu,et al.Mechanism of Chinese Medicine Polysaccharide in Treating Osteoporosis and Osteoarthritis: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(10):264-273.
冯晨曦,殷澳,侯相竹等.中药多糖治疗骨质疏松症和骨关节炎作用机制的研究进展[J].中国实验方剂学杂志,2023,29(10):264-273. DOI: 10.13422/j.cnki.syfjx.20230236.
FENG Chenxi,YIN Ao,HOU Xiangzhu,et al.Mechanism of Chinese Medicine Polysaccharide in Treating Osteoporosis and Osteoarthritis: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(10):264-273. DOI: 10.13422/j.cnki.syfjx.20230236.
骨质疏松症(OP)和骨关节炎(OA)是临床常见的骨病,OP是一种全身性骨骼疾病,OA是一种慢性退行性关节疾病,均具有患病率高、致残率高等特点。随着人口老龄化的到来,OP和OA的发病率逐年上升,成为老年人的常发疾病,严重影响了患者的生活质量和身心健康。中药治疗骨病历史悠久,在预防和治疗OP和OA等骨病上具有临床疗效好、不良反应小等优点,是治疗骨病的常用方法之一。多糖作为中药的活性物质之一,具有多种药理活性,且来源广泛,不良反应小,其作用不容忽视。多糖在骨病治疗中的作用研究越来越深入,人们发现中药多糖治疗OP和OA的作用机制涉及多层次、多靶点、多通路。通过对中药多糖治疗OP和OA作用机制的相关文献的分析归纳,发现中药多糖主要通过调控成骨细胞与破骨细胞的骨动态平衡、影响骨髓间质干细胞和骨微结构治疗OP;通过调控软骨细胞生长、提高软骨基质中蛋白聚糖和胶原含量、降低氧自由基含量和炎症介质水平治疗OA,旨在进一步探讨中药多糖治疗不同骨病作用机制之间的内在联系,为中药多糖治疗骨病的研究提供相关思路。
Osteoporosis (OP) and osteoarthritis (OA) are common bone diseases in clinic. OP is a systemic skeletal disease, and OA is a chronic degenerative joint disease with high prevalence and disability rates. With the advent of the aging population, the incidence rate of OA and OP is increasing year by year, and they have become common diseases of the elderly. The quality of life and physical and mental health of patients are severely affected by the above two bone diseases. Chinese medicine has a long history of treating bone diseases, with a good clinical effect on preventing and treating OP, OA, and other bone diseases with few side effects. It is one of the commonly used methods to treat bone diseases. Polysaccharides, as one of the active substances of Chinese medicine, have various pharmacological activities and a wide range of sources with low toxicity, and their effect cannot be ignored. The role of polysaccharides in the treatment of bone diseases has been deeply studied. It has been found that the mechanism of Chinese medicine polysaccharides in treating OP and OA involves multiple levels, targets, and pathways. Through the analysis and summary of the relevant literature on the mechanism of Chinese medicine polysaccharides in treating OP and OA, it was found that Chinese medicine polysaccharides mainly treated OP by regulating the bone dynamic balance between osteoblasts and osteoclasts and affecting bone marrow mesenchymal stem cells and bone microstructure. The mechanism of Chinese medicine polysaccharides in the treatment of OA is related to the regulation of chondrocyte growth, the increase in the proteoglycan and collagen content in the cartilage matrix, and the reduction of oxygen free radical content and inflammatory mediator level. This study aimed to further explore the internal relationship among mechanisms of Chinese medicine polysaccharides in the treatment of bone diseases, to provide relevant ideas for the study of Chinese medicine polysaccharides in the treatment of bone diseases.
多糖骨质疏松症骨关节炎研究进展
polysaccharidesosteoporosisosteoarthritisreview
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