Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine

CUI Yushi; GAO Yun; WANG Mingyuan; ZHANG Shuai; YANG Shengping; LI Xiaoyu; YAN Xin

doi:10.13422/j.cnki.syfjx.20230349

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Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine

更新时间：2023-06-20

- Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 14, Pages: 219-225(2023)
- 作者机构：
  
  中国中医科学院眼科医院，北京 100040
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20230349
  CLC： R22;R28;R96;G353.11
- Published：20 July 2023，
  
  Published Online：19 December 2022，
  
  Received：12 October 2022，
- 稿件说明：
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崔玉石,高云,王明远等.基于中西医临床病证特点的神经根型颈椎病动物模型分析[J].中国实验方剂学杂志,2023,29(14):219-225.

CUI Yushi,GAO Yun,WANG Mingyuan,et al.Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(14):219-225.
崔玉石,高云,王明远等.基于中西医临床病证特点的神经根型颈椎病动物模型分析[J].中国实验方剂学杂志,2023,29(14):219-225. DOI： 10.13422/j.cnki.syfjx.20230349.

CUI Yushi,GAO Yun,WANG Mingyuan,et al.Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(14):219-225. DOI： 10.13422/j.cnki.syfjx.20230349.

摘要

随着科学技术进步和社会节奏加快，“低头族”人数不断增加，颈椎退行性疾病的发病率亦逐年增加，神经根型颈椎病作为颈椎退变诱发的疾病之一，已严重危害人们的生活质量与身心健康。中医药治疗神经根型颈椎病确有疗效，但理论及基础实验依据尚不充分，且当前动物模型制定标准未统一。因此，笔者基于神经根型颈椎病的中西医临床指南及病证特点，对其现有动物模型进行系统归纳与分析，结果发现现有模型中微血管钳神经根压迫法的中西医指南吻合度较差，而椎管插线法、自体骨置入压迫法、不锈钢柱压迫法、固定架颈椎退变法等造模方法虽在西医指南体现出了较高的吻合度，但中医诊断标准吻合度较差。表明该疾病现有动物模型体现出的中医证候要素较少，且在动物行为学评价等方面缺乏类似中医四诊方面的信息采集与评估。总之，笔者旨在基于病证结合理念系统评价当前神经根型颈椎病动物模型建立现状，以期为更加符合临床发病特点、中西医病证特点模型的建立提供理论依据。

Abstract

With the acceleration of social rhythm， the progress of science and technology， and the increase of the number of phubbers， the incidence of cervical degenerative diseases is also increasing year by year. Cervical spondylotic radiculopathy（CSR）， as one of the diseases induced by cervical degeneration， has seriously affected people's quality of life and physical and mental health. Traditional Chinese medicine（TCM） is effective in the treatment of CSR， but the theoretical and basic experimental evidence is not sufficient， and the current formulation standard of animal model is not unified. Therefore， based on the clinical guidelines of Chinese and Western medicine for CSR and the characteristics of the disease and syndrome， the author systematically summarized and analyzed the existing animal models， and found that the existing models of microvascular clamp nerve root compression method had a poor agreement with the the Chinese and Western medical guidelines， while the modeling methods of spinal canal insertion， autologous bone insertion compression， stainless steel column compression， and fixed frame cervical degeneration reflected a high degree of agreement in the Western medical guidelines. However， the Chinese medical diagnostic criteria were poorly matched. This indicates that the existing animal models of this disease show few TCM syndrome elements， and lack information collection and evaluation in animal behavioral evaluation similar to the four diagnoses of TCM. In conclusion， this paper aims to systematically evaluate the current status of animal model establishment of CSR based on the concept of combination of disease and syndrome， so as to provide a theoretical basis for the model establishment of CSR that is more consistent with clinical characteristics and symptoms of Chinese and Western medicine.

关键词

神经根型颈椎病动物模型中西医结合病证结合临床指南吻合度颈椎退行性疾病

Keywords

cervical spondylotic radiculopathyanimal modelcombination of Chinese and Western medicinecombination of disease and syndromeclinical guidelinesanastomosiscervical degenerative diseases

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