ZHAO Panpan,WANG Zulong,CHEN Rubing.Effect of Wuwei Fuzheng Yijing Decoction on Sperm DNA Integrity in Male Infertility Patients[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(03):127-132.
ZHAO Panpan,WANG Zulong,CHEN Rubing.Effect of Wuwei Fuzheng Yijing Decoction on Sperm DNA Integrity in Male Infertility Patients[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(03):127-132. DOI: 10.13422/j.cnki.syfjx.20230397.
Effect of Wuwei Fuzheng Yijing Decoction on Sperm DNA Integrity in Male Infertility Patients
To observe the effect of Wuwei Fuzheng Yijing decoction on sperm DNA integrity in male infertility patients.
Method
2
One hundred male infertility patients with sperm DNA damage (spleen and kidney Qi deficiency and blood stasis) that met the inclusion criteria were randomly divided into an observation group (Wuwei Fuzheng Yijing decoction) and a control group (
L
-carnitine oral solution), with 50 cases in each group. After 12 weeks of treatment, the DNA fragmentation index (DFI) and traditional Chinese medicine (TCM) syndrome score, progressive sperm motility (PR), sperm survival rate, and sperm concentration of the two groups before and after treatment were observed and compared.
Result
2
The total effective rate of the observation group was 89.80% (44/49) higher than 62.50% (30/48) of the control group (
P
<
0.05). Compared with the conditions before treatment, the DFI and TCM syndrome score of the two groups were reduced after treatment, while the PR, sperm survival rate, and sperm concentration were increased (
P
<
0.05), and the observation group was superior to the control group in terms of the above indexes (
P
<
0.05).
Conclusion
2
Wuwei Fuzheng Yijing decoction obviously repairs sperm DNA of male infertility patients and improves sperm quality, with high safety.
关键词
Keywords
references
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Inhibition of Oxidative Stress by Wuzi Yanzongwan to Ameliorate Idiopathic Oligoasthenospermia: A Review
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