Theoretical Exploration of Luobing Theory Guides Study on Alzheimer's Disease Based on Neurovascular Protection

CHANG Liping; ZHANG Baoyu; LI Mengnan; GAO Lini; MA Jing; WEI Cong

doi:10.13422/j.cnki.syfjx.20230450

您当前的位置：

首页 >

文章列表页 >

Theoretical Exploration of Luobing Theory Guides Study on Alzheimer's Disease Based on Neurovascular Protection

更新时间：2023-05-17

- Theoretical Exploration of Luobing Theory Guides Study on Alzheimer's Disease Based on Neurovascular Protection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 7, Pages: 216-221(2023)
- 作者机构：
  
  1.络病研究与创新中药国家重点实验室，石家庄 050035
  2.河北以岭医药研究院，国家中医药管理局重点研究室（心脑血管络病），河北省络病重点实验室，石家庄 050035
  3.河北以岭医院吴以岭名老中医药专家传承工作室，石家庄 050090
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20230450
  CLC： R22;R24;R287;R592
- Published：05 April 2023，
  
  Published Online：30 January 2023，
  
  Received：02 January 2023，
- 稿件说明：
扫描看全文
常丽萍,张宝瑜,李梦南等.络病理论指导基于神经-血管保护的阿尔茨海默病理论探讨[J].中国实验方剂学杂志,2023,29(07):216-221.

CHANG Liping,ZHANG Baoyu,LI Mengnan,et al.Theoretical Exploration of Luobing Theory Guides Study on Alzheimer's Disease Based on Neurovascular Protection[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(07):216-221.
常丽萍,张宝瑜,李梦南等.络病理论指导基于神经-血管保护的阿尔茨海默病理论探讨[J].中国实验方剂学杂志,2023,29(07):216-221. DOI： 10.13422/j.cnki.syfjx.20230450.

CHANG Liping,ZHANG Baoyu,LI Mengnan,et al.Theoretical Exploration of Luobing Theory Guides Study on Alzheimer's Disease Based on Neurovascular Protection[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(07):216-221. DOI： 10.13422/j.cnki.syfjx.20230450.

摘要

基于中医气血相关理论，络病理论提出脑之气络与脉络相偕而行，在结构和功能方面“唇齿相依”，为脑主神明功能的重要基础；提出络气虚滞/郁滞、脉络瘀阻、神识失用为阿尔茨海默病主要病机，有别于现代医学重点关注神经元的研究策略；提出从神经元保护——清除

-淀粉样蛋白、磷酸化tau蛋白等病理产物和脑微血管保护——脑微血管结构与功能保护、促进治疗性血管新生、增加脑血流2个方面治疗阿尔茨海默病的必要性。在“络以通为用”治疗原则指导下研制的通络代表药物通心络胶囊具有微血管保护优势，可发挥血管保护介导的神经保护作用，临床研究证实其可有效治疗阿尔茨海默病、血管性痴呆及认知障碍相关疾病，可为从神经-血管保护全面防治阿尔茨海默病提供新思路和新途径。

Abstract

Based on the correlation between Qi and blood in traditional Chinese medicine， the collateral disease theory puts forward that the Qi-collateral go hand in hand with the vessel-collateral of the brain， and to be as close as lips to teeth in structure and function， which is an important basis for the function of brain governing mind. And this theory proposes that deficiency/stagnancy of collateral-Qi， stagnation of collaterals and loss of consciousness are the main pathogenesis of Alzheimer's disease（AD）， which is different from the research strategy of modern medicine focusing on neurons. It is suggested that it is necessary to treat AD from two aspects， including neuronal protection（elimination of pathological products such as

-amyloid and phosphorylated tau protein） and cerebral microvascular protection（protection of cerebral microvascular structure and function， promotion of therapeutic angiogenesis and increase of cerebral blood flow. Tongxinluo capsules is a representative drug for dredging collaterals developed under the guidance of the therapeutic principle of collaterals need circulation， it can protect microvessels and play a neuroprotective role mediated by vascular protection. Clinical studies have confirmed that Tongxinluo capsules can effectively treat AD， vascular dementia and cognitive impairment related diseases， which can provide new ideas and effective treatment ways to prevent and treat AD from neurovascular protection in a comprehensive manner.

关键词

络病理论阿尔茨海默病（AD）通心络胶囊神经保护脑微血管保护β-淀粉样蛋白tau蛋白

Keywords

collateral diseaseAlzheimer's diseaseTongxinluo capsulesneuroprotectioncerebral microvascular protectionβ-amyloidtau protein

references

田金洲，解恒革，王鲁宁，等.中国阿尔茨海默病痴呆诊疗指南（2020年版）［J］.中华老年医学杂志，2021，40（3）：269-283.

冯菲，李珩玉，赵宏伟，等.细叶远志皂苷治疗痴呆的研究进展［J］.中国实验方剂学杂志，2022，28（9）：258-265.

TIME MAGAZINE，THE GUARDIAN，THE SUNDAY TIME.World Alzheimer Report 2018［EB/OL］.（2018-09-21）［2023-01-01］.https：//www.alz.co.uk/news/world-alzheimer-report-2018-state-of-art-of-dementia-research-new-frontiershttps://www.alz.co.uk/news/world-alzheimer-report-2018-state-of-art-of-dementia-research-new-frontiers.

WITKOWSKA-PŁUSA U，DUBIELIS A，PŁUSA T.Recognizing Alzheimer's disease in daily practice［J］.Pol Merkur Lekarski，2022，50（298）：253-256.

ALZHEIMER'S ASSOCIATION.2015 Alzheimer's disease facts and figures［J］.Alzheimer's Dement，2015，11（3）：332-384.

JIA L F，DU Y F，CHU L，et al.Prevalence，risk factors，and management of dementia and mild cognitive impairment in adults aged 60 years or older in China：A cross-sectional study［J］.Lancet Public Health，2020，5（12）：e661-e671.

《中国痴呆与认知障碍诊治指南》写作组，中国医师协会神经内科医师分会认知障碍疾病专业委员会.中国阿尔茨海默病一级预防指南［J］.中华医学杂志，2020，100（35）：2721-2735.

《中国心血管健康与疾病报告》编写组.中国心血管健康与疾病报告2020概要［J］.中国循环杂志，2021，36（6）：521-545.

WANG Z B，WANG Z T，SUN Y，et al.The future of stem cell therapies of Alzheimer's disease［J］.Ageing Res Rev，2022，80：101655.

PASSERI E，ELKHOURY K，MORSINK M，et al.Alzheimer's disease：Treatment strategies and their limitations［J］.Int J Mol Sci，2022，23（22）：13954.

MACCIONI R B，CALFÍO C，GONZÁLEZ A，et al.Novel nutraceutical compounds in Alzheimer prevention［J］.Biomolecules，2022，12（2）：249.

田金洲，解恒革，秦斌，等.适用于中国人群的阿尔茨海默病筛查和诊断框架［J］.中华内科杂志，2019，58（2）：91-101.

REDDY P H，OLIVER D M.Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease［J］.Cells，2019，8（5）：488.

KOUTSODENDRIS N，NELSON M R，RAO A，et al.Apolipoprotein E and Alzheimer's disease：Findings，hypotheses，and potential mechanisms［J］.Annu Rev Pathol，2022，17：73-99.

MA C，HONG F F，YANG S L.Amyloidosis in Alzheimer's disease：Pathogeny，etiology，and related therapeutic directions［J］.Molecules，2022，27（4）：1210.

OSSENKOPPELE R，VAN-DER-KANT R，HANSSON O.Tau biomarkers in Alzheimer's disease：Towards implementation in clinical practice and trials［J］.Lancet Neurol，2022，21（8）：726-734.

HUR J Y.γ-Secretase in Alzheimer's disease［J］.Exp Mol Med.2022，54（4）：433-446.

TIWARI S，ATLURI V，KAUSHIK A，et al.Alzheimer's disease：Pathogenesis，diagnostics，and therapeutics［J］.Int J Nanomedicine，2019，14：5541-5554.

GIREUD-GOSS M，MACK A F，MCULLOUGH L D，et al.Cerebral amyloid angiopathy and blood-brain barrier dysfunction［J］.Neuroscientist，2020，27（6）：668-684.

TATULIAN S A.Challenges and hopes for Alzheimer's disease［J］.Drug Discov Today，2022，27（4）：1027-1043.

TRIGIANI L J，ROYEA J，LACALLE-AURIOLES M，et al.Pleiotropic benefits of the angiotensin receptor blocker candesartan in a mouse model of Alzheimer disease［J］.Hypertension，2018，72（5）：1217-1226.

王虎平，米彩云，周君.从“肝肾同调”探析黑逍遥散干预AD免疫炎症的研究思路［J］.中国实验方剂学杂志，2022，28（17）：180-187.

金硕果，刘福友，杨东东，等.基于胶质淋巴系统探讨“毒损脑络”［J］.中国实验方剂学杂志，2020，26（10）：186-191.

李红蓉，吴以岭.络病研究的传承与创新［J］.南京中医药大学学报，2022，doi：10.14148/j.issn.1672-0482.2022.1075http://dx.doi.org/10.14148/j.issn.1672-0482.2022.1075.

李红蓉，魏聪，贾振华，等.气络学说指导抗衰老研究［J］.中国实验方剂学杂志，2022，28（1）：7-15.

吴以岭.血管保护——脑梗死治疗的新靶点［J］.疑难病杂志，2006，5（5）：356-358.

常成成，魏聪.从脉络学说角度探讨通络治疗脉络-血管系统病规律［J］.中国中医基础医学杂志，2019，25（4）：487-489，500.

常成成，魏聪，常丽萍，等.络病理论研究概述及对当前临床的影响［J］.时珍国医国药，2021，32（6）：1432-1434.

张运旭.络病理论在心脑血管病治未病中的应用初探［J］.中国药理学通报，2021，37（3）：446.

刘深.“孙络—微血管”病变在缺血性中风发病中的作用探讨及通心络干预研究［D］.北京：北京中医药大学，2018.

阿不都克尤木·亚生，麦尔普·艾尼，努尔斯曼古丽·斯迪克.血管内介入联合静脉溶栓治疗急性缺血性脑血管病对患者脑神经功能缺损与血流动力学的影响［J］.现代医学与健康研究电子杂志，2020，4（5）：41-43.

李雅文，常丽萍，秘红英，等.基于脉络学说探析慢性冠脉综合征的病机及治疗［J］.中国实验方剂学杂志，2021，27（1）：196-202.

TRIPATHI S M，MURRAY A D.Alzheimer's dementia：The emerging role of positron emission tomography［J］.Neuroscientist，2022，28（5）：507-519.

周英奕，时晶，魏明清，等.基于动脉自旋磁共振技术探讨阿尔茨海默病脑血流特点与认知功能的关系［J］.中华脑血管病杂志：电子版，2021，15（5）：302-307.

ZHANG M，LIU Y，XU M J，et al.Carotid artery plaque intervention with Tongxinluo capsule （CAPITAL）：A multicenter randomized double-blind parallel-group placebo-controlled study［J］.Sci Rep，2019，9（1）：4545.

SHUANG S，HOU Y L，WU Y L.Tongxinluo preserves the renal function in diabetic kidney disease via protecting the HK-2 cells from the patterns of programmed cell death［J］.J Paediatr Child Health，2021（16）：52-64.

LIU S，CHANG L P，WEI C.The sonic hedgehog pathway mediates Tongxinluo capsule-induced protection against blood-brain barrier disruption after ischaemic stroke in mice［J］.Basic Clin Pharmacol Toxicol，2019，124（6）：660-669.

张志慧，贾振华，康健生，等.Aβ损伤人脑微血管内皮细胞培养液对正常神经元凋亡的影响及通心络胶囊的干预作用［J］.中国实验方剂学杂志，2017，23（17）：166-171.

杨萍，李然，郑程程，等.通心络胶囊佐治腔隙性脑梗死伴血管性认知功能障碍患者的疗效及对细胞因子、血液流变学的影响［J］.疑难病杂志，2016，15（7）：742-746.

陈阳昊，孔丽娅，毛盈颖，等.通心络胶囊治疗血管性痴呆临床疗效及安全性的Meta分析［J］.浙江中医药大学学报，2019，43（5）：504-511.

何穗智，邓卓燊，吴伟康，等.通心络胶囊治疗脑血管病的Meta分析［C］//中华中医药学会.络病理论及其应用经典论文选编，2014年卷.出版者不详，2014：167-171.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Neuroprotective Effect of Chinese Medicinal Compounds Effective in Supplementing Qi and Resolving Phlegm on Alzheimer's Disease： A Review

Mechanism of Dihuang Yinzi in Improving Astrocyte Injury and Glycolysis in AD Mice via PI3K/Akt Pathway

Effect of Danzhi Xiaoyaosan on Phosphorylation of Tau Protein in Rats with Alzheimer's Disease Based on PP2A and GSK-3β

Role of Autophagy in Alzheimer's Disease and Its Research Progress in Traditional Chinese Medicine： A Review

Mechanisms of Danggui Shaoyaosan in Improving Cognitive Ability in SAMP8 Mice by Regulating Gut Microbiota via 16S rDNA Sequencing

Related Author

WANG Shaofeng

HAO Yanwei

LI Jiaxin

YUE Shengnan

LIU Qingsong

LI Bin

YU Hongni

SUN Mengjie

Related Institution

Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Japan Friendship Hospital

School of Traditional Chinese Medicine,Beijing University of Chinese Medicine

Dongfang Hospital,Beijing University of Chinese Medicine

Gansu Key Laboratory of Traditional Chinese Medicine（TCM）Excavation and Innovative Transformation， Gansu Engineering Laboratory for New Products of TCM

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰