Application Regularity and Mechanism of Chinese Marine Drug Pair Haliotidis Concha-Oystreae Concha Based on Literature Mining Technology

ZHUANG Peijun; HAO Erwei; LI Zeyu; DU Zhengcai; HOU Xiaotao; DENG Jiagang

doi:10.13422/j.cnki.syfjx.20230811

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Application Regularity and Mechanism of Chinese Marine Drug Pair Haliotidis Concha-Oystreae Concha Based on Literature Mining Technology

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- Application Regularity and Mechanism of Chinese Marine Drug Pair Haliotidis Concha-Oystreae Concha Based on Literature Mining Technology
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 19, Pages: 211-219(2023)
- 作者机构：
  
  1.广西中药药效研究重点实验室，南宁 530200
  2.广西农作物废弃物功能成分研究协同创新中心，南宁 530200
  3.广西中医湿病方药理论与转化重点实验室，南宁 530200
  4.广西中医药大学药学院，南宁 530200
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20230811
  CLC： R284;R285;R289;R287;R22;R2-031;R33;R24
- Published：05 October 2023，
  
  Published Online：25 June 2023，
  
  Received：26 April 2023，
- 稿件说明：
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庄培钧,郝二伟,李泽宇等.基于文献挖掘技术的海洋中药药对“石决明-牡蛎”应用规律及作用机制[J].中国实验方剂学杂志,2023,29(19):211-219.

ZHUANG Peijun,HAO Erwei,LI Zeyu,et al.Application Regularity and Mechanism of Chinese Marine Drug Pair Haliotidis Concha-Oystreae Concha Based on Literature Mining Technology[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(19):211-219.
庄培钧,郝二伟,李泽宇等.基于文献挖掘技术的海洋中药药对“石决明-牡蛎”应用规律及作用机制[J].中国实验方剂学杂志,2023,29(19):211-219. DOI： 10.13422/j.cnki.syfjx.20230811.

ZHUANG Peijun,HAO Erwei,LI Zeyu,et al.Application Regularity and Mechanism of Chinese Marine Drug Pair Haliotidis Concha-Oystreae Concha Based on Literature Mining Technology[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(19):211-219. DOI： 10.13422/j.cnki.syfjx.20230811.

摘要

目的

对石决明-牡蛎的临床应用热点、发展趋势、配伍特点、应用规律及组方作用机制进行分析，为该药对临床用药及深入研究提供参考。

方法

基于中国知网等多种现代文献数据库，检索含有石决明-牡蛎药对临床应用热点及现代临床处方，对药对临床应用热点及发展趋势利用Citespace进行可视化分析，对处方的药物组成、功效主治、药物剂量等进行统计，运用SPSS Modeler 18.0等多种统计软件对石决明-牡蛎药对主治病症及配伍用药规律进行分析。

结果

可视化分析中共纳入90篇文献，该领域近几年发文逐渐下降，其中临床应用热点关键词为高血压、络虚生风、失眠等。临床处方共检索到80首，涉及121味中药，配伍用药频次分析表明应用频率前10位的药物分别是钩藤、天麻、龙骨、牛膝、白芍、菊花、黄芩、栀子、甘草、首乌藤。关联规则分析表明核心配伍主要有“钩藤-牛膝” “龙骨-地龙-川芎”等，并结合因子可靠性分析，得到的新药物组合为“天麻-首乌藤-杜仲-桑寄生-益母草”“牛膝-钩藤” “黄芩-甘草-珍珠-夏枯草”“龙骨-地龙-僵蚕”“菊花-川芎” “茯苓-石菖蒲” “白芍-栀子-茯神”。石决明-牡蛎药对配伍主要用于治疗肝阳上亢型的病证，其中高血压占40.00%、偏头痛占30.00%、眩晕占15.00%；该药对用于治疗肝阳上亢病证时，主要的配伍药物分类为平肝息风药占19.86%、活血化瘀药占12.13%、安神药占10.08%。组方高频中药通过提高血浆一氧化氮（NO）水平、下调血管紧张素Ⅱ（Ang Ⅱ）、抑制血管紧张素转换酶（ACE）等多途径发挥降低血压的作用。

结论

通过对该研究结果的综合分析，石决明-牡蛎药对临床应用多用于肝阳上亢型高血压，多与补虚药、平肝息风药、清热药、安神药为主进行配伍，目的在于在息风止痉、平肝潜阳的同时，兼顾清热泻里、安定神智，增强该药对平肝潜阳之功效。

Abstract

Objective

To analyze the clinical application hotspots， development trends， compatibility characteristics， application rules， and formulation mechanisms of the Chinese marine drug pair Haliotidis Concha-Oystreae Concha in order to provide references for its clinical medication and further research.

Method

By means of various modern literature databases such as China National Knowledge Infrastructure （CNKI）， modern clinical prescriptions containing Haliotidis Concha-Oystreae Concha， as well as the clinical application hotspots， were retrieved， followed by visualized analysis of hotspots and development trends of their clinical applications using Citespace. The drug composition， efficacy and indications， and drug dosages in the prescriptions were statistically analyzed. Additionally， various statistical software including SPSS Modeler 18.0 were employed to analyze the indications， syndromes， and formulation rules of Haliotidis Concha-Oystreae Concha.

Result

The visualized analysis included 90 articles， revealing a gradual decrease in publications in this field in recent years. Key clinical application keywords were identified as hypertension， collateral deficiency producing wind， insomnia， etc. Eighty clinical prescriptions were retrieved， involving 121 drugs. Frequency analysis of compatibility demonstrated that the top 10 drugs were Uncariae Ramulus cum Uncis， Gastrodiae Rhizoma， Os Draconis， Achyranthis Bidentatae Radix， Paeoniae Radix Alba， Chrysanthemi Flos， Scutellariae Radix， Gardeniae Frucuts， Glycyrrhizae Radix et Rhizoma， and Polygoni Multiflori Caulis

Association rule analysis showed that core combinations included "Uncariae Ramulus cum Uncis-Achyranthis Bidentatae Radix" and "Os Draconis-Pheretima-Chuanxiong Rhizoma". Through factor reliability analysis， new drug combinations were derived， such as "Gastrodiae Rhizoma-Polygoni Multiflori Caulis-Eucommiae Cortex-Taxilli Herba-Leonuri Herba"， "Achyranthis Bidentatae Radix-Uncariae Ramulus cum Uncis"， "Scutellariae Radix-Glycyrrhizae Radix et Rhizoma-Margarita-Prunellae Spica"， "Os Draconis-Pheretima-Bombyx Batryticatus"， "Chrysanthemi Flos-Chuanxiong Rhizoma"， "Poria-Acori Tatarinowii Rhizoma"， and "Paeoniae Radix Alba-Gardeniae Fructus-Sclerotium Poriae Pararadicis". The Haliotidis Concha-Oystreae Concha drug pair was mainly used to treat diseases with liver Yang hyperactivity syndrome， with hypertension accounting for 40.00%， migraines for 30.00%， and dizziness for 15.00%. In the treatment of liver Yang hyperactivity syndrome， the main categories of compatible drugs were liver-pacifying and wind-extinguishing ones （19.86%）， blood-activating and stasis-resolving ones （12.13%）， and spirit-calming ones （10.08%）. High-frequency drugs in the prescriptions function to reduce blood pressure through multiple pathways， such as increasing nitric oxide （NO） levels， downregulating angiotensin Ⅱ （Ang Ⅱ）， and inhibiting angiotensin-converting enzyme （ACE）.

Conclusion

Through comprehensive analysis of the results， the Haliotidis Concha-Oystreae Concha drug pair is commonly used for hypertension with liver Yang hyperactivity syndrome， and is often combined with deficiency-tonifying， liver-pacifying and wind-extinguishing， heat-clearing， and spirit-calming drugs， aiming to simultaneously extinguish wind， relieve spasms， and pacify the liver to subdue Yang， while also clearing heat to relax bowels， stabilizing the mind， and enhancing the liver-pacifying and Yang-subduing effects of this drug pair.

关键词

海洋中药药对石决明-牡蛎应用规律作用机制

Keywords

Chinese marine drugdrug pairHaliotidis Concha-Oystreae Conchaapplication regularitymechanism of action

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