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Regulation of Signaling Pathways Associated with Gastric Cancer by Chinese Medicine： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 16, Pages: 217-228(2023)
- 作者机构：
1.广西中医药大学 研究生院，南宁 530001
2.广西中医药大学 附属瑞康医院，南宁 530000
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20230836
CLC： R2-0;R33;R353.11;R735.2Published：20 August 2023，
Published Online：20 June 2023，
Received：14 May 2023，
- 稿件说明：
扫 描 看 全 文
杨靖芸,谢家诚,马晓聪等.胃癌相关信号通路的中药调控研究进展[J].中国实验方剂学杂志,2023,29(16):217-228.
YANG Jingyun,XIE Jiacheng,MA Xiaocong,et al.Regulation of Signaling Pathways Associated with Gastric Cancer by Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(16):217-228.
杨靖芸,谢家诚,马晓聪等.胃癌相关信号通路的中药调控研究进展[J].中国实验方剂学杂志,2023,29(16):217-228. DOI： 10.13422/j.cnki.syfjx.20230836.
YANG Jingyun,XIE Jiacheng,MA Xiaocong,et al.Regulation of Signaling Pathways Associated with Gastric Cancer by Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(16):217-228. DOI： 10.13422/j.cnki.syfjx.20230836.
摘要
胃癌是一种常见的消化道恶性肿瘤，其发病机制尚未完全阐明。尽管手术、放疗、化疗、靶向治疗和免疫治疗等在治疗胃癌方面取得了较好的临床疗效，但是这些治疗方法存在并发症多、不良反应大等问题。中药在近年来的基础实验和临床研究中被证实能够治疗胃癌，并取得了良好的疗效。中药的特点是多成分、多靶点，而胃癌的发病机制尚未完全明确，这决定了中药防治胃癌存在相关作用机制不明等问题。因此，需要从现代医学的角度出发，从分子生物学、网络药理学等层面揭示中药防治胃癌的作用机制。中医学认为胃癌的发生主要归结于肝气郁结、痰瘀气滞、津亏热结、正气衰败、癌毒胶结等因素。在文献中，中药复方主要为补益剂、清热解毒剂，如三草调胃汤、小建中汤、益气化瘀解毒汤等，而中药单体主要为攻毒杀虫类、清热类、活血化瘀药和理气药等。这些中药与中医学所认为的胃癌发生的病因病机相符合。研究发现，中药还可以通过调控磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）信号通路、丝裂原活化蛋白激酶（MAPK）信号通路、核转录因子-
κ
B（NF-
κ
B）信号通路、转化生长因子-
β
（TGF-
β
）/Smad信号通路、Wnt/
β
-catenin信号通路、Hedgehog信号通路发挥促进细胞凋亡、促进细胞自噬、阻滞细胞周期、逆转细胞耐药等作用来治疗胃癌，但缺乏系统认识。该研究通过系统总结中药调控胃癌的相关信号通路，旨在明确中药治疗在胃癌分子机制发生发展及侵袭转移等过程中的相关作用机制，以期为胃癌的治疗提供新的靶点、新的视角和新的思路，促进中医药现代化发展。
Abstract
Gastric cancer is a common malignant tumor of the gastrointestinal tract， with the pathogenesis remains to be fully elucidated. Although surgery， radiotherapy， chemotherapy， targeted therapy， and immunotherapy have demonstrated obvious clinical efficacy in the treatment of gastric cancer， the patients suffer from complications and adverse effects. Basic experiments and clinical studies have proved that Chinese medicine can treat gastric cancer in a multi-component and multi-target manner， the mechanisms of which remain to be deciphered. Therefore， the mechanism of Chinese medicine against gastric cancer needs to be unveiled by network pharmacology and tools of molecular biology. According to Chinese medicine， the occurrence of gastric cancer is mainly attributed to liver Qi stagnation， phlegm stasis and Qi stagnation， body fluid deficiency and heat accumulation， deficiency of healthy Qi， and cancer toxin accumulation. According to the available literature， herbal compound formulas such as Sancao Tiaowei decoction， Xiaojianzhong decoction， and Yiqi Huayu Jiedu decoction focus on tonifying， clearing heat， and detoxifying， while herbal active components are mainly insecticidal， heat-clearing， blood-activating， stasis-removing， and Qi-regulating drugs. The therapeutic effects of these Chinese medicines are consistent with the etiology and pathogenesis of gastric cancer. It has been demonstrated that Chinese medicines play a role in promoting apoptosis and autophagy， blocking cell cycle， and reversing cellular drug resistance to treat gastric cancer by regulating phosphatidylinositol-3 kinase/protein kinase B （PI3K/Akt）， mitogen-activated protein kinase （MAPK）， nuclear factor-kappa B （NF-
κ
B）， transforming growth factor-
β
（TGF-
β
）/Smad， Wnt/
β
-catenin， and Hedgehog signaling pathways， while there is a lack of systematic understanding. By systematically summarizing the signaling pathways related to the regulation of gastric cancer by Chinese medicine， this study aims to clarify the molecular mechanisms of Chinese medicine against the development， invasion， and metastasis of gastric cancer， with a view to providing new targets， perspectives， and ideas for the treatment of gastric cancer and promoting the modernization of traditional Chinese medicine.
关键词
胃癌中药信号通路研究进展
Keywords
gastric cancerChinese medicinesignaling pathwayresearch progress
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