Tannin Components of <italic style="font-style: italic">Geranium</italic> Plants in Prevention and Treatment of Alzheimer's Disease： A Review

CHEN Linyi; HE Bo; SHEN Zhiqiang

doi:10.13422/j.cnki.syfjx.20230913

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Tannin Components of Geranium Plants in Prevention and Treatment of Alzheimer's Disease： A Review

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- Tannin Components of Geranium Plants in Prevention and Treatment of Alzheimer's Disease： A Review
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 20, Pages: 257-264(2023)
- 作者机构：
  
  昆明医科大学药学院云南省天然药物药理重点实验室，昆明 650500
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20230913
  CLC： R284.2;R285;R289;R287;R22;R2-031;R33;R24
- Published：20 October 2023，
  
  Published Online：27 July 2023，
  
  Received：08 May 2023，
- 稿件说明：
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陈临宜,何波,沈志强.老鹳草属药用植物鞣质成分及防治阿尔茨海默病研究进展[J].中国实验方剂学杂志,2023,29(20):257-264.

CHEN Linyi,HE Bo,SHEN Zhiqiang.Tannin Components of Geranium Plants in Prevention and Treatment of Alzheimer's Disease： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(20):257-264.
陈临宜,何波,沈志强.老鹳草属药用植物鞣质成分及防治阿尔茨海默病研究进展[J].中国实验方剂学杂志,2023,29(20):257-264. DOI： 10.13422/j.cnki.syfjx.20230913.

CHEN Linyi,HE Bo,SHEN Zhiqiang.Tannin Components of Geranium Plants in Prevention and Treatment of Alzheimer's Disease： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(20):257-264. DOI： 10.13422/j.cnki.syfjx.20230913.

摘要

阿尔茨海默病（AD）是一种神经系统退行性疾病，其发病机制主要有

淀粉样蛋白（A

）过度沉积、神经炎症反应、微管相关蛋白（Tau蛋白）过度磷酸化等，目前临床还没有找到有效的治疗药物。而传统中草药可以通过多成分多靶点发挥抗AD作用成为研究热点。老鹳草作为我国的一味传统中药已有600余年的临床药用历史，其具备巨大的药用潜力和广阔的应用前景。老鹳草属药用植物的化学成分类型主要包括鞣质、黄酮、有机酸及挥发油等。研究表明，中药老鹳草中多种鞣质化学成分具有改善学习记忆能力和认知功能障碍等药理活性，其机制涉及抗A

、调节Tau蛋白、抗氧化、抗炎、抑制乙酰胆碱酯酶活性等，其能通过多途径、多靶点抑制神经元的退行性改变，从而有效防治阿尔茨海默病等神经退行性疾病。通过查阅分析相关文献后，着重对中药老鹳草属中多种鞣质组分及其在防治阿尔茨海默病方面的研究进行综述。并通过探讨中药老鹳草属植物中的鞣质组分及其作用机制，筛选出潜在治疗阿尔茨海默病等神经退行性疾病的药物组分，为其进一步开发和临床应用提供理论基础及研究思路。

Abstract

Alzheimer's disease （AD） is a neurodegenerative disorder characterized by mechanisms including excessive deposition of

amyloid （A

）， neuroinflammatory responses， and hyperphosphorylation of microtubule-associated protein （Tau protein）. Currently， there are no effective clinical treatments available for AD. Traditional Chinese herbal drugs have gained attention for their potential to exert anti-AD effects through multi-component， multi-target approaches. As a traditional Chinese herbal drug with over 600 years of clinical use， Geranii Herba has substantial medicinal potential and wide application prospects.

Geranium

medicinal plants contain chemical components such as tannins， flavonoids， organic acids， and volatile oils. Research has indicated that various tannin compounds found in Geranii Herba possess pharmacological activities like enhancing learning and memory abilities， and improving cognitive function. These effects are linked to mechanisms involving anti-A

effects， Tau protein regulation， antioxidation， anti-inflammation， and inhibition of acetylcholinesterase activity. These compounds can act through multiple pathways and targets to inhibit neurodegenerative changes in neurons， thus effectively preventing and treating neurodegenerative diseases like AD. Based on relevant literature， this study focused on reviewing various tannin components in

Geranium

plants

and their role in preventing and treating AD and identified potential drug components for treating neurodegenerative diseases such as AD by exploring the tannin components and their mechanisms in

Geranium

plants， thereby providing a theoretical foundation and research direction for further development and clinical application.

关键词

老鹳草鞣质化学成分阿尔滋海默

Keywords

Geraniumtanninchemical componentsAlzheimer's disease

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Tannin Components of Geranium Plants in Prevention and Treatment of Alzheimer's Disease： A Review

DOI：10.13422/j.cnki.syfjx.20230913

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