Antidepressant Effects of Oligosaccharides and Polysaccharides in Chinese Medicine： A Review

WANG Yulu; CAI Shuo; LI Bin

doi:10.13422/j.cnki.syfjx.20231164

您当前的位置：

首页 >

文章列表页 >

Antidepressant Effects of Oligosaccharides and Polysaccharides in Chinese Medicine： A Review

更新时间：2023-11-20

- Antidepressant Effects of Oligosaccharides and Polysaccharides in Chinese Medicine： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 24, Pages: 210-217(2023)
- 作者机构：
  
  中国药科大学天然药物活性组分与药效国家重点实验室，南京 210009
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20231164
  CLC： R22;R28;R971+.43;G353.11
- Published：20 December 2023，
  
  Published Online：07 June 2023，
  
  Received：27 April 2023，
- 稿件说明：
扫描看全文
王雨露,蔡朔,李彬.中药寡糖与多糖的抗抑郁作用研究进展[J].中国实验方剂学杂志,2023,29(24):210-217.

WANG Yulu,CAI Shuo,LI Bin.Antidepressant Effects of Oligosaccharides and Polysaccharides in Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(24):210-217.
王雨露,蔡朔,李彬.中药寡糖与多糖的抗抑郁作用研究进展[J].中国实验方剂学杂志,2023,29(24):210-217. DOI： 10.13422/j.cnki.syfjx.20231164.

WANG Yulu,CAI Shuo,LI Bin.Antidepressant Effects of Oligosaccharides and Polysaccharides in Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(24):210-217. DOI： 10.13422/j.cnki.syfjx.20231164.

摘要

抑郁症是一种常见的精神类疾病，严重影响患者的身心健康与生活质量，已成为全球重大疾病负担之一。抑郁症病因复杂，其发病机制尚未形成定论，存在多种发病机制假说。目前临床上使用的抗抑郁药物主要通过选择性抑制中枢神经突触前膜对单胺类神经递质的再摄取发挥作用，但这类药物普遍存在起效慢、疗效不佳、耐药性明显等问题。研究人员逐渐将目光转向研发具有新作用机制的抗抑郁药物。中药寡糖与多糖是一类来源丰富的中药活性成分，多项研究表明巴戟天寡糖、远志寡糖酯、茯苓多糖、黄芪多糖等具有较好的抗抑郁活性，其药理作用涉及多种作用机制，包括提高脑内单胺类神经递质水平、抑制下丘脑-垂体-肾上腺轴（HPA轴）亢进、增加神经营养因子（NTF）表达、调节免疫炎症反应及调节微生物-肠-脑轴等。因此，中药寡糖与多糖可能通过发挥整合调节作用改善抑郁症，成为了安全高效抗抑郁新药研发的重要来源之一。本文系统总结了近年来的研究情况，以期为阐明中药寡糖与多糖的抗抑郁作用机制提供参考。

Abstract

Depression is a common psychiatric disease that seriously affects the physical and mental health and quality of life of patients， and has become one of the major global disease burdens. The etiology of depression is intricate， and despite extensive research， its pathogenesis remains inconclusive， resulting in various hypotheses of its onset mechanisms. Presently， the primary approach for clinically treating depression involves the utilization of selective inhibitors targeting the reuptake of monoamine neurotransmitters within the central nervous system. However， these drugs are generally characterized by delayed onset of action， limited efficacy and obvious resistance. Recently， researchers have gradually turned their attention to the development of antidepressant drugs with novel mechanisms. Notably， as a category of abundantly available active ingredients in Chinese medicine， numerous pharmacological studies have demonstrated that oligosaccharides and polysaccharides possess promising antidepressant properties， such as Morindae Officinalis Radix oligosaccharides， Polygalae Radix oligosaccharide esters， Poria polysaccharides and Astragali Radix polysaccharides. Their pharmacological mechanisms are various， including enhancing the levels of monoamine neurotransmitters in the brain， inhibiting the hyperactivation of the hypothalamic-pituitary-adrenal axis（HPA axis）， increasing the expression of neurotrophic factors（NTF）， regulating immune-inflammatory responses and modulating the microbiota-gut-brain axis. Therefore， oligosaccharides and polysaccharides from Chinese medicine have become a vital source of safe and effective novel antidepressant candidates due to the potential to improve depression through integrated regulatory effects. This article aims to provide a comprehensive and systematic review of recent progress to contribute to the elucidation of the mechanisms underlying the antidepressant effects of oligosaccharides and polysaccharides derived from Chinese medicine.

关键词

中医药寡糖多糖抗抑郁作用神经递质下丘脑-垂体-肾上腺轴（HPA轴）免疫炎症反应

Keywords

traditional Chinese medicineoligosaccharidespolysaccharidesantidepressant effectsneurotransmittershypothalamic-pituitary-adrenal axis（HPA axis）immunoinflammatory response

references

YAO C，JIANG X，YE X，et al.Antidepressant drug discovery and development：Mechanism and drug design based on small molecules［J］.Adv Ther，2022，5（5）：2200007.

ZHAO Y J，CHEN J B，LIU Q L，et al.Profiling the structural determinants of aryl benzamide derivatives as negative allosteric modulators of mGluR5 by in silico study［J］.Molecules，2020，25（2）：406.

刘强，李洪超，马爱霞.一线抗抑郁药临床疗效的网状Meta分析［J］.中国药物评价，2016，33（2）：106-110.

于冰清，邵欣欣，付晓凡，等.抗抑郁中药复方的组方特点及作用机制研究［J］.中草药，2021，52（11）：3344-3352.

WANG Y S，SHEN C Y，JIANG J G.Antidepressant active ingredients from herbs and nutraceuticals used in TCM： Pharmacological mechanisms and prospects for drug discovery［J］.Pharmacol Res，2019，150：104520.

LIU M，CAI M，DING P.Oligosaccharides from traditional Chinese herbal medicines： A review of chemical diversity and biological activities［J］.Am J Chinese Med，2021，49（3）：577-608.

GUO Y，CHEN X，GONG P，et al.Advances in the mechanisms of polysaccharides in alleviating depression and its complications［J］.Phytomedicine，2022，109：154566.

蔡兵，崔承彬，陈玉华，等.巴戟天中菊淀粉型低聚糖类单体成分对小鼠的抗抑郁作用［J］.中国药理学与毒理学杂志，1996，10（2）：109-111.

HU Y，LIU M，LIU P，et al.Possible mechanism of the antidepressant effect of 3，6′-disinapoyl sucrose from Polygala tenuifolia Willd［J］.J Pharm Pharmacol，2011，63（6）：869-874.

陈可琢，陈实，任洁贻，等.茯苓酸性多糖抗抑郁作用及其调节神经递质和NLRP3通路机制研究［J］.中国中药杂志，2021，46（19）：5088-5095.

张武霞，陈露，段金友.三种中药多糖的抗抑郁活性及其机制研究［J］.山西农业大学学报：自然科学版，2017，37（12）：905-912.

CHEN P，HEI M，KONG L，et al.One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome［J］.Food Funct，2019，10（12）：8161-8171.

DAI W，FENG K，SUN X，et al.Natural products for the treatment of stress-induced depression：Pharmacology，mechanism and traditional use［J］.J Ethnopharmacol，2022，285：114692.

LI Y F，YUAN L，XU Y K，et al.Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats［J］.Acta Pharmacol Sin，2001，22（12）：1084-1088.

谢婷婷，孙艳，王东晓，等.远志YZ-50对慢性应激抑郁模型大鼠行为学及血清CRH ACTH和COR的影响［J］.解放军药学学报，2008，24（2）：95-98.

楚胜.枸杞多糖对创伤后应激障碍大鼠抑郁的保护作用研究［J］.现代预防医学，2019，46（14）：2622-2625.

刘佳蕾，王宇亮，赵宏，等.百合多糖与黄芪多糖联用对慢性应激小鼠抑郁行为的影响及机制［J］.中国实验方剂学杂志，2022，28（5）：62-70.

MOLENDIJK M L，SPINHOVEN P，POLAK M，et al.Serum BDNF concentrations as peripheral manifestations of depression： Evidence from a systematic review and meta-analyses on 179 associations（N=9484）［J］.Mol Psychiatr，2014，19（7）：791-800.

LI Y F，LIU Y Q，YANG M，et al.The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone［J］.Life Sci，2004，75（13）：1531-1538.

徐德峰，宓为峰，张素贞，等.巴戟天寡糖抗抑郁作用机制研究［J］.中国临床药理学杂志，2015，31（15）：1539-1542.

张建英，汤娟，张倩，等.硫酸茯苓多糖对抑郁症大鼠海马AMPA受体表达的影响［J］.中国临床心理学杂志，2019，27（6）：1086-1091.

丁继红，姜春玉，杨乐，等.刺五加多糖调控PI3K/Akt/mTOR通路改善大鼠抑郁行为的作用［J］.食品工业科技，2022，43（11）：369-375.

马丽，张颖，潘菊华，等.开心解郁方对抑郁模型大鼠行为学与血清炎性细胞因子的影响［J］.世界科学技术—中医药现代化，2017，19（8）：1334-1339.

王轶，郭婷婷，尹勇玉，等.菊淀粉型巴戟天寡糖对慢性应激模型小鼠抑郁、焦虑样行为的改善及对调节性T细胞数量的调节作用［J］.中国药理学与毒理学杂志，2022，36（6）：426-434.

LI Z，XU H，XU Y，et al.Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation［J］.CNS Neurosci Ther，2021，27（12）：1570-1586.

史云静，李玉霞.茯苓多糖通过NF-κB和NLRP3信号通路调节脂多糖引起的焦虑和抑郁样行为［J］.食品工业科技，2023，44（12）：371-377.

王煜，李承德，曲敬蓉，等.黄芪多糖对抑郁大鼠海马NF-κB信号通路的影响［J］.中国药理学通报，2018，34（6）：836-840.

LIU P，BAI X Y，ZHANG T，et al.The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome［J］.Ann Transl Med，2019，7（24）：811.

HU S，LI A，HUANG T，et al.Gut microbiota changes in patients with bipolar depression［J］.Adv Sci，2019，6（14）：1900752.

王琦，赵映霞，赵慧亮，等.肠道菌群在中药抗抑郁作用中的研究进展［J］.药学学报，2022，57（12）：3494-3501.

ZHANG Z W，GAO C S，ZHANG H，et al.Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota［J］.Acta Pharm Sin B，2022，12（8）：3298-3312.

SUN J，WANG F，HU X，et al.Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressive-like behavior in mice via the gut-brain axis［J］.J Agr Food Chem，2018，66（31）：8415-8421.

YAN T，NIAN T，LIAO Z，et al.Antidepressant effects of a polysaccharide from okra （Abelmoschus esculentus （L） Moench） by anti-inflammation and rebalancing the gut microbiota［J］.Int J Biol Macromol，2020，144：427-440.

ZHU J，PENG Q，XU Y，et al.Morinda officinalis oligosaccharides ameliorate depressive-like behaviors in poststroke rats through upregulating GLUT3 to improve synaptic activity［J］.FASEB J，2020，34（10）：13376-13395.

HU Y，LIAO H B，GUO D H，et al.Antidepressant-like effects of 3，6′-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats［J］.Neurochem Int，2010，56（3）：461-465.

龙亚秋，谢文源，李华，等.附子多糖对抑郁大鼠模型的影响［J］.河北医学，2017，23（6）：1029-1031.

YAN H C，QU H D，SUN L R，et al.Fuzi polysaccharide-1 produces antidepressant-like effects in mice［J］.Int J Neuropsychoph，2010，13（5）：623-633.

梁霜，黄仁彬，王乃平，等.玉郎伞多糖对大鼠不同脑区腺苷酸环化酶的影响［J］.时珍国医国药，2010，21（9）：2221-2222.

陆玉丹，黄仁彬，何萍.玉郎伞多糖对慢性应激抑郁小鼠行为学及海马结构的影响［J］.中国实验方剂学杂志，2013，19（1）：220-223.

LIANG S，HUANG R，LIN X，et al.Effects of Yulangsan polysaccharide on monoamine neurotransmitters，adenylate cyclase activity and brain-derived neurotrophic factor expression in a mouse model of depression induced by unpredictable chronic mild stress［J］.Neural Regen Res，2012，7（3）：191-196.

刘萌萌，张伊，张耀元，等.天麻多糖对脂多糖诱导抑郁小鼠的作用及机制研究［J］.中国药师，2021，24（11）：2018-2023.

丁超，许寅，葛韵芝.当归多糖对慢性应激抑郁小鼠的行为影响及其机制研究［J］.西部中医药，2021，34（6）：21-27.

刘丽珠，刘薇，樊琳，等.黄芪多糖对大鼠脑卒中后抑郁的影响［J］.中国医药导报，2019，16（7）：11-14.

王元元，邓卫平，李晓强，等.黄芪多糖提高脑卒中后抑郁模型大鼠学习能力的实验观察［J］.实验动物与比较医学，2019，39（6）：443-448.

宿宏佳，王冬梅，张腾，等.黄芪多糖对抑郁大鼠海马Nrf2-ARE通路的影响［J］.中国药理学通报，2021，37（6）：839-843.

韦震，宋洪波，安凤平，等.黄精多糖对急性抑郁小鼠模型的改善作用及机制［J］.食品工业科技，2022，43（6）：351-357.

陈辰，徐维平，魏伟，等.黄精多糖对慢性应激抑郁小鼠模型行为学及脑内5-HT的影响［J］.山东医药，2009，49（4）：39-41.

SHEN F，SONG Z，XIE P，et al.Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress，inflammation，and cellular and synaptic damage［J］.J Ethnopharmacol，2021，275：114164.

YANG Y，FAN L，PENG Y，et al.Alcohol-soluble polysaccharides from Dendrobium officinale flowers as an antidepressant by regulating the gut-brain axis［J］.Int J Biol Macromol，2022，216：836-849.

LI H R，XIAO Y H，HAN L，et al.Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system［J］.Brain Res Bull，2021，171：16-24.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis on Sugar Spectrum Difference Between Wild-simulated and Transplanted Astragali Radix

Mechanism of CGAS-STING Signaling Pathway in Regulating Ischemic Stroke and Intervention of Traditional Chinese Medicine： A Review

Related Author

LI Hufeng

LI Ke

LYU Wanwan

FENG Shihong

WEN Yuwei

LI Zhenyu

QIN Xuemei

DU Yuguang

Related Institution

Modern Research Center for Traditional Chinese Medicine（TCM），Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education，Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM，Shanxi University

Institute of Process Engineering，Chinese Academy of Sciences

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM），National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

Tianjin University of TCM

Dongzhimen Hospital，Beijing University of Chinese Medicine

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰