Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-<italic style="font-style: italic">κ</italic>B Signaling Pathway： A Review

LI Zishun; ZHAO Changpu; CHEN Renwu; LI Meiling; WANG Fei; HAO Chenyuan

doi:10.13422/j.cnki.syfjx.20231244

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Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-κB Signaling Pathway： A Review

更新时间：2023-11-07

- Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-κB Signaling Pathway： A Review
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 23, Pages: 275-282(2023)
- 作者机构：
  
  1.河南中医药大学第二临床医学院，郑州 450002
  2.河南省中医院，郑州 450002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20231244
  CLC： R2-0;R33;R256.4;G353.11
- Published：05 December 2023，
  
  Published Online：08 September 2023，
  
  Received：24 July 2023，
- 稿件说明：
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李子舜,赵长普,陈仁伍等.中医药基于NF-κB信号通路治疗肝纤维化的研究进展[J].中国实验方剂学杂志,2023,29(23):275-282.

LI Zishun,ZHAO Changpu,CHEN Renwu,et al.Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-κB Signaling Pathway： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):275-282.
李子舜,赵长普,陈仁伍等.中医药基于NF-κB信号通路治疗肝纤维化的研究进展[J].中国实验方剂学杂志,2023,29(23):275-282. DOI： 10.13422/j.cnki.syfjx.20231244.

LI Zishun,ZHAO Changpu,CHEN Renwu,et al.Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-κB Signaling Pathway： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):275-282. DOI： 10.13422/j.cnki.syfjx.20231244.

摘要

肝纤维化是慢性肝病的常见并发症，其严重影响了患者的生活质量，并导致肝硬化和肝癌等严重后果。目前，现代医学在肝纤维化的治疗中取得了一定的进展，但仍然面临一些挑战和局限性。因此，寻找新的治疗策略具有重要的临床意义。核转录因子-

B（NF-

B）信号通路在炎症和免疫反应中起着重要的调节作用。最近的研究表明，NF-

B信号通路在肝纤维化的发生和发展中也发挥着关键作用。NF-

B信号通路的异常激活导致肝脏炎症和纤维化相关基因的过度表达，从而促进肝纤维化的发展。中医药作为一种传统的治疗方法，具有独特的优势和潜力。近年来，越来越多的研究表明，中医药可以通过调节NF-

B信号通路来治疗肝纤维化。中药中的活性成分可以干预NF-

B信号通路的激活，抑制炎症反应和纤维化过程，从而减轻肝纤维化的程度。该篇旨在综述中医药在治疗肝纤维化中的作用机制及其对NF-

B信号通路的调节作用，对相关的中药和中药方剂进行评述，讨论其在肝纤维化治疗中的临床应用前景，并为进一步的研究和临床实践提供有益的参考。

Abstract

Hepatic fibrosis is a common complication of chronic liver disease， seriously affecting patients' quality of life and leading to severe consequences such as cirrhosis and liver cancer. Modern medicine has made progress in the treatment of hepatic fibrosis， while it still faces certain challenges and limitations. Therefore， seeking new therapeutic strategies is of great clinical significance. The nuclear factor-

B （NF-

B） signaling pathway plays a role in regulating inflammation and immune responses. Recent studies have shown that the NF-

B signaling pathway plays a key role in the occurrence and development of hepatic fibrosis. The abnormal activation of the NF-

B signaling pathway leads to the overexpression of genes related to liver inflammation and fibrosis， thereby promoting the development of hepatic fibrosis. Traditional Chinese medicine （TCM） is a traditional treatment method with unique advantages and potential. In recent years， increasing studies have proved that TCM can treat hepatic fibrosis by regulating the NF-

B signaling pathway. The active ingredients in Chinese herbal medicines can intervene in the activation of the NF-

B signaling pathway to inhibit inflammatory responses， thereby reducing the severity of hepatic fibrosis. This article reviews the mechanisms of TCM in treating hepatic fibrosis via the NF-

B signaling pathway and evaluates the efficacy and discusses the clinical application prospects of relevant Chinese herbs and formulae， aiming to provide references for further research and clinical practice.

关键词

肝纤维化核转录因子-κB（NF-κB）信号通路中医药炎症抗纤维化

Keywords

hepatic fibrosisnuclear factor-κB （NF-κB） signaling pathwaytraditional Chinese medicineinflammationanti-fibrosis

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Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-κB Signaling Pathway： A Review

DOI：10.13422/j.cnki.syfjx.20231244

摘要

Abstract

关键词

Keywords

references