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Chinese Medicine Regulates mTOR Signaling Pathway to Prevent and Treat Osteoporosis： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 23, Pages: 253-263(2023)
- 作者机构：
1.甘肃中医药大学，兰州 730000
2.甘肃省人民医院，兰州 730000
3.甘肃省中医院，兰州 730050
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20231314
CLC： R284;R285;R289;R287;R22;R2-031;R33;R24Published：05 December 2023，
Published Online：16 October 2023，
Received：25 July 2023，
- 稿件说明：
扫 描 看 全 文
吴沂泽,李兴勇,吕汐妍等.中药干预mTOR信号通路防治骨质疏松症研究进展[J].中国实验方剂学杂志,2023,29(23):253-263.
WU Yize,LI Xingyong,LYU Xiyan,et al.Chinese Medicine Regulates mTOR Signaling Pathway to Prevent and Treat Osteoporosis： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):253-263.
吴沂泽,李兴勇,吕汐妍等.中药干预mTOR信号通路防治骨质疏松症研究进展[J].中国实验方剂学杂志,2023,29(23):253-263. DOI： 10.13422/j.cnki.syfjx.20231314.
WU Yize,LI Xingyong,LYU Xiyan,et al.Chinese Medicine Regulates mTOR Signaling Pathway to Prevent and Treat Osteoporosis： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):253-263. DOI： 10.13422/j.cnki.syfjx.20231314.
摘要
骨质疏松症（OP）是一种老年人多见的全身性骨骼疾病，其病理特征是骨流失、骨微结构退变等，其临床上多表现为骨骼脆性增加、骨痛等症状。同时，OP会因其引起的骨骼高脆性而增加骨折风险，最终导致OP患者终身残疾或死亡，给患者及其家庭带来了沉重的经济负担和心理负担。既往研究发现，OP发病机制极其复杂，与成骨细胞增殖与分化、破骨细胞活性与功能的障碍和自噬激活的异常等众多因素相关。近年来，国内外研究发现，哺乳动物雷帕霉素靶蛋白（mTOR）相关信号通路参与骨稳态的调节，可通过调控成骨细胞增殖与分化、破骨细胞功能、激活细胞自噬而促进骨形成、改善骨代谢和骨微结构，在OP防治中发挥着至关重要的作用。此外，中医药防治OP历史悠久、疗效明确，且具有作用靶点多、不良反应小、来源广泛的特点和优势。因此，该文通过检索和查阅国内外最新研究报道，简略阐述了mTOR相关信号通路在OP发生发展中的作用，详细总结了中药提取物及中药复方干预mTOR相关信号通路防治OP的最新研究成果，旨为mTOR相关信号通路与OP的关系、临床应用中医药防治OP等领域的深入研究提供参考和依据。
Abstract
Osteoporosis （OP）， a common systemic skeletal disease in the elderly， is characterised by bone loss and bone microstructural degeneration. Its clinical manifestations include increased bone fragility and bone pain. Furthermore， OP increases the risk of fracture due to the high bone fragility， which leads to lifelong disability or death， imposing a heavy economic and psychological burden on the patients and their families. The pathogenesis of OP is extremely complex and associated with a variety of factors such as proliferation and differentiation of osteoblasts， impairment of osteoclast activity and function， and abnormalities in autophagy activation. Recent studies have found that mammalian target of rapamycin （mTOR） signaing pathway is involved in the regulation of bone homeostasis， which can promote bone formation and improve bone metabolism and bone microstructure by regulating osteoblast proliferation and differentiation and osteoclast function and activating cellular autophagy， thus playing a crucial role in the prevention and treatment of OP. The prevention and treatment of OP with Chinese medicine has a long history， clear efficacy， multiple targets of action， low adverse effects， and wide medicine sources. Therefore， this paper briefly describes the role of mTOR signaling pathway in the development of OP by reviewing the latest research reports and summarizes in detail the latest research results on the treatment of OP with Chinese medicine extracts and prescriptions via the mTOR signaling pathway. This review aims to provide a basis for the in-depth research on the relationship between mTOR signaling pathway and OP and the clinical application of traditional Chinese medicine in the prevention and treatment of OP.
关键词
哺乳动物雷帕霉素靶蛋白（mTOR）信号通路磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）/mTOR信号通路腺苷-磷酸（AMP）活化蛋白激酶（AMPK）/mTOR信号通路骨质疏松症中医药
Keywords
mammalian target of rapamycin （mTOR） signaling pathwayphosphatidylinositol 3-kinase（PI3K）/protein kinase B（Akt）/mTOR signaling pathwayadenosine monophosphate（AMP）-activated protein kinase（AMPK）/mTOR signaling pathwayosteoporosistraditional Chinese medicine
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