“Significant progress has been made in the field of immunology in 2022, covering innate immunity, inflammasomes, T cell immunity, B cell function, immune exhaustion, and the immunological mechanisms of COVID-19. Interdisciplinary collaboration and technological integration have driven the development of immunology, with high-throughput sequencing, full spectrum flow cytometry, gene editing, protein engineering, AI combined with biotechnology providing strong support for in-depth research on immune response characteristics, patterns, underlying mechanisms, and targets. The research results provide new ideas for developing effective treatment methods, vaccines, and drugs. However, the variation of novel coronavirus, the characteristics of immune escape, the effectiveness and safety of immunotherapy for tumor and autoimmune diseases still need to be further studied.”