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Inhibition of Oxidative Stress by Wuzi Yanzongwan to Ameliorate Idiopathic Oligoasthenospermia： A Review
更新时间：2024-04-30
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    • Inhibition of Oxidative Stress by Wuzi Yanzongwan to Ameliorate Idiopathic Oligoasthenospermia： A Review

    • “特发性少弱精子症在男性不育诊疗中受到越来越多的关注。氧化应激损伤是导致该病症的主要原因之一，它直接影响精子质量和精子发生。研究发现，精子质膜磷脂对活性氧极为敏感，易导致脂质过氧化，进而诱导铁死亡。同时，氧化应激还会干扰精子DNA修复和凋亡途径，抑制睾酮生成，最终影响精子发生。五子衍宗丸作为中医治疗IO的经典名方，其药效物质研究取得了显著进展。通过建立中药特征图谱和探索有效成分作用靶点的药理学研究，发现其主要活性成分为黄酮类和苯丙素类化合物，具有较强的抗氧化活性。研究表明，五子衍宗丸可以抑制IO模型中过高的ROS水平，提高机体抗氧化能力，改善炎症状态，抑制细胞凋亡，并促进睾酮生成，从而缓解氧化应激导致的精子质量下降和精子发生不足。这一研究不仅为IO的治疗提供了新的药物选择，也为中药药效物质研究和生殖内分泌疾病的研究开辟了新的方向。未来，我们可以进一步探索五子衍宗丸的药理作用机制，优化治疗方案，为男性不育患者带来更好的治疗效果。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 238-244(2024)

    • DOI：10.13422/j.cnki.syfjx.20231496    

      CLC： R242;R2-031;R256.56;R699

    • Published：05 June 2024，

      Published Online：23 April 2024，

      Received：08 December 2023，

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  • ZHANG Jiacheng,HU Hangqi,JIN Yuxin,et al.Inhibition of Oxidative Stress by Wuzi Yanzongwan to Ameliorate Idiopathic Oligoasthenospermia： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):238-244. DOI： 10.13422/j.cnki.syfjx.20231496.

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