Objective

2

To investigate the clinical value of Longbeisan application at Shenque （CV 8） combined with oral administration of Chinese medicine in the treatment of premature ejaculation （PE）.

Method

2

A total of 98 PE patients treated in the andrology department of the First Affiliated Hospital of Henan University of Chinese Medicine at the same time period were randomly assigned into an observation group and a control group， with 49 patients in each group. The observation group received Longbeisan application at Shenque （CV 8） combined with oral treatment of Chinese medicine according to syndrome differentiation， and the control group was treated with dapoxetine hydrochloride tablets. The treatment in both groups lasted for 8 weeks. The intravaginal ejaculatory latency time （IELT）， Chinese index of premature ejaculation-5 （CIPE-5） score， patient's sexual life satisfaction， spouse's sexual life satisfaction， effective rate， and adverse reaction incidence were compared between the two groups.

Result

2

After treatment， the observation group had higher total effective rate than the control group ［（85.71% （42/49） vs. 67.35% （33/49），

χ

2

=6.262，

P

<

0.05］. The IELT， CIPE-5 score， and patient's and spouse's satisfaction scores after treatment increased compared with those before treatment （

P

<

0.01）， and the increases were more significant in the observation group （

P

<

0.05，

P

<

0.01）. The clinical effect of the observation group was better than that of the control group. During the treatment， 7 （7/49，14.29%） patients in the control group and 2 ，2/49，4.08%） patients in the observation group showed adverse reactions， which indicated the safety of the observation group was better than that of the control group （

χ

2

=9.000，

P

<

0.05）. In the follow-up period， 11 （11/49，22.45%） patients in the control group and 3 （3/49，6.12%） patients in the observation group showed aggravation of symptoms， which meant that the observation group had better lasting effect （

χ

2

=0.317，

P

<

0.05）.

Conclusion

2

Longbeisan application at Shenque （CV 8） combined with oral administration of Chinese medicine has better clinical effect， stronger safety， and longer effect than dapoxetine hydrochloride in the treatment of PE.