浏览全部资源
扫码关注微信
Traditional Chinese Medicine Intervention in Colorectal Cancer Based on NF-
κ B Signaling Pathway： A Review- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 19, Pages: 243-256(2023)
- 作者机构：
1.广西中医药大学 研究生学院，南宁 530001
2.广西中医药大学 第一附属医院，南宁 530001
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20231599
CLC： R2-0;R22;R2-031;R574.62;R735Published：05 October 2023，
Published Online：19 July 2023，
Received：08 December 2022，
- 稿件说明：
扫 描 看 全 文
徐明瑶,黎丽群,刘鑫等.中药通过NF-κB信号通路干预结直肠癌的研究进展[J].中国实验方剂学杂志,2023,29(19):243-256.
XU Mingyao,LI Liqun,LIU Xin,et al.Traditional Chinese Medicine Intervention in Colorectal Cancer Based on NF-κB Signaling Pathway： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(19):243-256.
徐明瑶,黎丽群,刘鑫等.中药通过NF-κB信号通路干预结直肠癌的研究进展[J].中国实验方剂学杂志,2023,29(19):243-256. DOI： 10.13422/j.cnki.syfjx.20231599.
XU Mingyao,LI Liqun,LIU Xin,et al.Traditional Chinese Medicine Intervention in Colorectal Cancer Based on NF-κB Signaling Pathway： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(19):243-256. DOI： 10.13422/j.cnki.syfjx.20231599.
摘要
结直肠癌（CRC）是全世界癌症患者死亡的主要原因之一，其发病率及死亡率呈逐年上升趋势。该病起病隐匿，发病初期缺少特异性症状，多数患者确诊时已处于晚期，现已成为消化系统肿瘤领域的热点研究问题。CRC的发病机制尚不明确，涉及遗传、基因突变、炎症反应、肿瘤相关信号通路的异常激活等因素。核转录因子-
κ
B（NF-
κ
B）是一种重要的转录因子，参与炎症反应、免疫反应、细胞增殖和细胞凋亡等多种生物学过程。有研究表明，作为连接炎症和癌症的分子中枢，NF-
κ
B在CRC中高度表达，并通过调控细胞促炎因子、趋化因子、血管生成因子、转移因子及抗凋亡蛋白等靶基因的活性，促进CRC的发生发展。目前，CRC的常用治疗策略是手术、放疗和5-氟尿嘧啶等化疗药物，但存在不良反应较大、转移率高、易产生耐药性等局限性。因此，需要寻找高效、低不良反应的药物来替代或补充当前的治疗。近年来，中医药在防治CRC上取得了一定的成效，研究发现中医药能够通过调控NF-
κ
B信号通路抑制CRC细胞的生长，从而在CRC的发病及病情的进展过程中发挥积极的作用。故而，基于CRC本虚标实、虚实夹杂的病机特点，该文总结和分析了中药靶向NF-
κ
B信号通路干预CRC的机制和作用，梳理了具有祛邪、扶正解毒功效的10个中药复方及黄酮类、酚类、生物碱类、苷类、萜类等37个不同类型的中药单体成分靶向NF-
κ
B通路防治CRC的研究现状，发现中药通过调控NF-
κ
B信号通路抑制CRC细胞增殖、侵袭、转移、血管生成、炎症反应，并诱导细胞凋亡、恢复药物及放疗敏感性，进而拮抗CRC，以期为CRC机制的深入探索及治疗提供一定的参考和依据。
Abstract
Colorectal cancer （CRC） is one of the leading causes of cancer-related deaths worldwide， with increasing incidence and mortality rates. The disease often develops covertly and lacks specific symptoms in its early stages， leading to late-stage diagnoses in most patients. It has become a prominent research topic in the field of digestive system tumors. The exact mechanisms underlying CRC are not yet clear and involve factors such as genetics， gene mutations， inflammatory responses， and aberrant activation of tumor-related signaling pathways. Nuclear factor-kappa B （NF-
κ
B） is a crucial transcription factor that participates in various biological processes， including inflammatory responses， immune responses， cell proliferation， and apoptosis. Research suggests that NF-
κ
B， serving as a molecular link between inflammation and cancer， is highly expressed in CRC. It promotes the occurrence and development of CRC by regulating the activity of target genes such as cell pro-inflammatory factors， chemokines， angiogenic factors， metastasis factors， and anti-apoptotic proteins. Currently， common treatments for CRC include surgery， radiation therapy， and chemotherapy drugs like 5-fluorouracil. However， these treatments have limitations such as significant adverse reactions， high metastasis rates， and the development of drug resistance. Therefore， the search for effective， low-adverse-reaction drugs to replace or supplement current treatments is essential. In recent years， traditional Chinese medicine （TCM） has shown some effectiveness in preventing and treating CRC. TCM has been found to inhibit the growth of CRC cells by modulating the NF-
κ
B signaling pathway， playing a positive role in the occurrence and progression of CRC. Based on the asthenia in origin and sthenia in superficiality and deficiency-excess in complexity in CRC， this article summarized and analyzed the mechanisms and effects of TCM interventions targeting the NF-
κ
B signaling pathway in CRC， and reviewed advances of 10 Chinese medicinal compound formulas and 37 Chinese medicinal monomer components of different types， including flavonoids， phenols， alkaloids， glycosides， and terpenoids with the effects of dispelling pathogenic factors， reinforcing healthy qi， and removing toxins in the prevention and treatment of CRC by targeting the NF-
κ
B pathway. It is found that Chinese medicine can inhibit CRC cell proliferation， invasion， metastasis， angiogenesis， and inflammation by modulating the NF-
κ
B signaling pathway， induce cell apoptosis， restore drug and radiation sensitivity， and counteract CRC. This article is expected to provide insights and references for the in-depth exploration and treatment of CRC mechanisms.
关键词
结直肠癌核转录因子-κB（NF-κB）信号通路中药研究进展
Keywords
colorectal cancernuclear factor-kappa B（NF-κB）signaling pathwayChinese medicineresearch progress
references
LIPSYC-SHARF M，ZHANG S，OU F S，et al.Survival in young-onset metastatic colorectal cancer：Findings from cancer and leukemia group B （Alliance）/SWOG 80405［J］.J Natl Cancer Inst，2022，114（3）：427-435.
SOLEIMANI A，RAHMANI F，FERNS G A，et al.Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer［J］.Gene，2020，726：144132.
国家癌症中心，国家肿瘤质控中心结直肠癌质控专家委员会.中国原发性结直肠癌规范诊疗质量控制指标（2022版）［J］.中华肿瘤杂志，2022，44（7）：623-627.
王华胜，李晓洁，王东，等.结直肠癌中医辨证分型与miR-29、miR-34a表达的相关性分析［J］.现代肿瘤医学，2022，30（10）：1806-1811.
陈叶青，李晓琳，陈子睿，等.基于数据挖掘的结直肠癌中医证型与中药应用规律研究［J］.中国中医基础医学杂志，2022，28（3）：412-416.
MARTIN M，SUN M，MOTOLANI A，et al.The pivotal player：Components of NF-κB pathway as promising biomarkers in colorectal cancer［J］.Int J Mol Sci，2021，22（14）：7429.
GE H，XU C，CHEN H，et al.Traditional Chinese Medicines as effective reversals of epithelial-mesenchymal transition induced-metastasis of colorectal cancer：Molecular targets and mechanisms［J］.Front Pharmacol，2022，13：842295.
THOMS H C，STARK L A.The NF-κB nucleolar stress response pathway［J］.Biomedicines，2021，9（9）：1082.
LIU X，SHAO Y，ZHOU J，et al.Nuclear factor κB Signaling and its related non-coding RNAs in cancer therapy［J］.Mol Ther Nucleic Acids，2020，19：208-217.
KHURANA N，DODHIAWALA P B，BULLE A，et al.Deciphering the role of innate immune NF-κB pathway in pancreatic cancer［J］.Cancers （Basel），2020，12（9）：2675.
PENG C，OUYANG Y，LU N，et al.The NF-κB signaling pathway，the microbiota，and gastrointestinal tumorigenesis：Recent advances［J］.Front Immunol，2020，11：1387.
CHEN Q，LU X，ZHANG X.Noncanonical NF-κB signaling pathway in liver diseases［J］.J Clin Transl Hepatol，2021，9（1）：81-89.
HU R，CHANTANA W，PITCHAKARN P，et al.Ficus dubia latex extract induces cell cycle arrest and apoptosis by regulating the NF-κB pathway in inflammatory human colorectal cancer cell lines［J］.Cancers （Basel），2022，14（11）：2665.
WENG W，FENG J，QIN H，et al.Molecular therapy of colorectal cancer：Progress and future directions［J］.Int J Cancer，2015，136（3）：493-502.
GONZÁLEZ-QUEZADA B A，SANTANA-BEJARANO U F，CORONA-RIVERA A，et al.Expression profile of NF-κB regulated genes in sporadic colorectal cancer patients［J］.Oncol Lett，2018，15（5）：7344-7354.
ZHANG W，LU Y，LI X，et al.CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer［J］.Biochem Biophys Res Commun，2018，500（2）：196-203.
ALADHRAEI M，KASSEM AL-THOBHANI A，POUNGVARIN N，et al.Association of XPO1 overexpression with NF-κB and Ki67 in colorectal cancer［J］.Asian Pac J Cancer Prev，2019，20（12）：3747-3754.
TIAN R，LIU X，LUO Y，et al.Apoptosis exerts a vital role in the treatment of colitis-associated cancer by herbal medicine［J］.Front Pharmacol，2020，11：438.
PATEL M，HORGAN P G，MCMILLAN D C，et al.NF-κB pathways in the development and progression of colorectal cancer［J］.Transl Res，2018，197：43-56.
ZHANG Y，ZHANG Y，ZHAO Y，et al.Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects［J］.Mol Med Rep，2022，25（5）：188.
LIU T，DUO L，DUAN P.Ginsenoside Rg3 sensitizes colorectal cancer to radiotherapy through downregulation of proliferative and angiogenic biomarkers［J］.Evid Based Complement Alternat Med，2018，2018：1580427.
YANG Z，ZHANG C，QI W，et al.GLI1 promotes cancer stemness through intracellular signaling pathway PI3K/Akt/NF-κB in colorectal adenocarcinoma［J］.Exp Cell Res，2018，373（1/2）：145-154.
MA X，SU J，ZHAO S，et al.CCL3 promotes proliferation of colorectal cancer related with TRAF6/NF-κB molecular pathway［J］.Contrast Media Mol Imaging，2022，2022：2387192.
TANG F，CAO F，LU C，et al.Dvl2 facilitates the coordination of NF-κB and Wnt signaling to promote colitis-associated colorectal progression［J］.Cancer Sci，2022，113（2）：565-575.
BAO M，MA Y，LIANG M，et al.Research progress on pharmacological effects and new dosage forms of baicalin［J］.Vet Med Sci，2022，8（6）：2773-2784.
CUI J，LI H，WANG Y，et al.Skullcapflavone Ⅰ has a potent anti-pancreatic cancer activity by targeting miR-23a［J］.Biofactors，2020，46（5）：821-830.
SONG L，ZHU S，LIU C，et al.Baicalin triggers apoptosis，inhibits migration，and enhances anti-tumor immunity in colorectal cancer via TLR4/NF-κB signaling pathway［J］.J Food Biochem，2022，46（3）：e13703.
ZHANG W，LI W，HAN X.Skullcapflavone I inhibits proliferation of human colorectal cancer cells via down-regulation of miR-107 expression［J］.Neoplasma，2019，66（2）：203-210.
HAN J，WANG P，XIA X，et al.EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR-150-5p/c-Myc in osteosarcoma［J］.J Cell Mol Med，2021，25（17）：8479-8489.
ZENG S，TAN L，SUN Q，et al.Suppression of colitis-associated colorectal cancer by scutellarin through inhibiting Hedgehog signaling pathway activity［J］.Phytomedicine，2022，98：153972.
WANG Y，WANG J，XIANG H，et al.Recent update on application of dihydromyricetin in metabolic related diseases［J］.Biomed Pharmacother，2022，148：112771.
WANG Z，SUN X，FENG Y，et al.Dihydromyricetin reverses MRP2-induced multidrug resistance by preventing NF-κB-Nrf2 signaling in colorectal cancer cell［J］.Phytomedicine，2021，82：153414.
QI W，QI W，XIONG D，et al.Quercetin：Its antioxidant mechanism，antibacterial properties and potential application in prevention and control of toxipathy［J］.Molecules，2022，27（19）：6545.
FREDOTOVIĆ Ž，PUIZINA J，NAZLIĆ M，et al.Phytochemical characterization and screening of antioxidant，antimicrobial and antiproliferative properties of Allium × cornutum Clementi and two varieties of Allium cepa L.peel extracts［J］.Plants （Basel），2021，10（5）：832.
QI J H，DONG F X，WANG X L.Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology［J］.Mol Divers，2022，26（3）：1731-1742.
刘博，张传凤，马克龙，等.基于STAT-3/NF-κB/ICAM-1通路探讨丹皮酚缓解小鼠结肠炎相关性结直肠癌的作用机制［J］.安徽中医药大学学报，2021，40（1）：88-92.
张晓梅，赵玉涛，王菊美，等.姜黄素对结直肠癌细胞迁移、侵袭和上皮间质转化的影响及作用机制［J］.世界中医药，2021，16（17）：2596-2599.
LU L，PRZYBYLLA R，SHANG Y，et al.Microsatellite status and IκBα expression levels predict sensitivity to pharmaceutical curcumin in colorectal cancer cells［J］.Cancers（Basel），2022，14（4）：1032.
JUNG E J，PARAMANANTHAM A，KIM H J，et al.Artemisia annua L.polyphenol-induced cell death is ROS-independently enhanced by inhibition of JNK in HCT116 colorectal cancer cells［J］.Int J Mol Sci，2021，22（3）：1366.
JUNG E J，PARAMANANTHAM A，KIM H J，et al.Identification of growth factors，cytokines and mediators regulated by Artemisia annua L.polyphenols （pKAL） in HCT116 colorectal cancer cells：TGF-β1 and NGF-β attenuate pKAL-induced anticancer effects via NF-κB p65 upregulation［J］.Int J Mol Sci，2022，23（3）：1598.
WANG X，LIU Q，FU Y，et al.Magnolol as a potential anticancer agent：A proposed mechanistic insight［J］.Molecules，2022，27（19）：6441.
Su CM，Weng YS，Kuan LY，et al.Suppression of PKCδ/NF-κB signaling and apoptosis induction through extrinsic/intrinsic pathways are associated magnolol-inhibited tumor progression in colorectal cancer in vitro and in vivo［J］.Int J Mol Sci，2020，21（10）：3527.
BOHARA R A，TABASSUM N，SINGH M P，et al.Recent overview of Resveratrol's beneficial effects and its Nano-delivery systems［J］.Molecules，2022，27（16）：5154.
BUHRMANN C，YAZDI M，POPPER B，et al.Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it［J］.Exp Biol Med （Maywood），2019，244（1）：1-12.
BHAGYA N，CHANDRASHEKAR K R.Autophagy and cancer：Can tetrandrine be a potent anticancer drug in the near future？［J］.Biomed Pharmacother，2022，148：112727.
王月霞，张治进，张玉浩，等.粉防己碱对人结直肠癌HCT116细胞株生物功能的影响及其机制［J］.江苏大学学报：医学版，2020，30（4）：336-341，346.
CAO Z，CHEN L，LIU Y，et al.Oxysophoridine rescues spinal cord injury via anti‑inflammatory，anti‑oxidative stress and anti‑apoptosis effects［J］.Mol Med Rep，2018，17（2）：2523-2528.
金少举，王蓉，李海龙，等.氧化槐定碱通过下调IKK/IκB/NF-κB信号通路抑制结直肠癌SW480细胞增殖［J］.中药药理与临床，2019，35（2）：63-67.
FAN M，YAO L.The synthesis，structural modification and mode of anticancer action of evodiamine：A review［J］.Recent Pat Anticancer Drug Discov，2022，17（3）：284-296.
CHAN S，SUN R，TU X，et al.Rutaecarpine suppresses the proliferation and metastasis of colon cancer cells by regulating the STAT3 signaling［J］.J Cancer，2022，13（3）：847-857.
MARTHANDAM ASOKAN S，MARIAPPAN R，MUTHUSAMY S，et al.Pharmacological benefits of neferine - A comprehensive review［J］.Life Sci，2018，199：60-70.
ZHOU Y，XIANG S，ZHENG H，et al.Neferine suppresses experimental colitis-associated colorectal cancer by inhibition of NF-κB p65 and STAT3［J］.Am J Chin Med，2022，50（5）：1387-1400.
XIONG R G，HUANG S Y，WU S X，et al.Anticancer effects and mechanisms of berberine from medicinal herbs：An update review［J］.Molecules，2022，27（14）：4523.
CHEN H，YE C，CAI B，et al.Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota［J］.BMC Cancer，2022，22（1）：566.
TAKEDA S，MIYASAKA K，SHIMODA H.Lycoperoside H，a steroidal alkaloid saponin in tomato seeds，ameliorates atopic dermatitis-like symptoms in IL-33 transgenic mice［J］.J Food Biochem，2021，45（9）：e13877.
LIU Y，QI X.Anti-inflammatory and antioxidant effect of lycoperoside H against the 1，2-dimethyl hydrazine （DMH） induced colorectal cancer in rats［J］.J Oleo Sci，2022，71（7）：1021-1029.
ZHANG X，XIE L，LONG J，et al.Salidroside：A review of its recent advances in synthetic pathways and pharmacological properties［J］.Chem Biol Interact，2021，339：109268.
EL-KOTT A F，ELBEALY E R，ALSHEHRI A S，et al.Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R，NF-κB and STAT3［J］.Cancer Biomark，2021，31（1）：13-25.
BAKR A F，SHAO P，FARAG M A.Recent advances in glycyrrhizin metabolism，health benefits，clinical effects and drug delivery systems for efficacy improvement； a comprehensive review［J］.Phytomedicine，2022，99：153999.
WANG G，HIRAMOTO K，MA N，et al.Glycyrrhizin attenuates carcinogenesis by inhibiting the inflammatory response in a murine model of colorectal cancer［J］.Int J Mol Sci，2021，22（5）：2609.
HE Z，HU Y，NIU Z，et al.A review of pharmacokinetic and pharmacological properties of asiaticoside，a major active constituent of Centella asiatica （L.） Urb［J］.J Ethnopharmacol，2022，302（Pt A）：115865.
ZHOU X，KE C，LV Y，et al.Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer［J］.Int J Mol Med，2020，46（4）：1525-1537.
XIA L，ZHANG B，YAN Q，et al.Effects of saponins of patrinia villosa against invasion and metastasis in colorectal cancer cell through NF-κB signaling pathway and EMT［J］.Biochem Biophys Res Commun，2018，503（3）：2152-2159.
GU G，QI H，JIANG T，et al.Investigation of the cytotoxicity，apoptosis and pharmacokinetics of Raddeanin A［J］.Oncol Lett，2017，13（3）：1365-1369.
WANG Y，BAO X，ZHAO A，et al.Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/β-catenin and NF-κB signaling pathway［J］.Life Sci，2018，207：532-549.
NAKHJAVANI M，SMITH E，TOWNSEND A R，et al.Anti-angiogenic properties of Ginsenoside Rg3［J］.Molecules，2020，25（21）：4905.
OTTO-ŚLUSARCZYK D，MIELCZAREK-PUTA M，GRABOŃ W.The real cytotoxic effect of artemisinins on colon cancer cells in a physiological cell culture setting.How composition of the culture medium biases experimental findings［J］.Pharmaceuticals （Basel），2021，14（10）：976.
邓平，陈新文.青蒿素对人结直肠癌Lovo细胞放疗敏感性的影响及其机制［J］.中国医学工程，2018，26（8）：14-19.
HWANG J，YOUN K，JI Y，et al.Biological and computational studies for dual cholinesterases inhibitory effect of zerumbone［J］.Nutrients，2020，12（5）：1215.
HOSSEINI N，KHOSHNAZAR A，SAIDIJAM M，et al.Zerumbone suppresses human colorectal cancer invasion and metastasis via modulation of FAk/PI3k/NFκB-uPA pathway［J］.Nutr Cancer，2019，71（1）：159-171.
CHEN X，HUANG M，LIU D，et al.Absorption and transport characteristics and mechanisms of carnosic acid［J］.Biology （Basel），2021，10（12）：1278.
LI S，YANG H，LI L，et al.The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer［J］.Chem Biol Interact，2022，365：110080.
LAI Z，HE J，ZHOU C，et al.Tanshinones：An update in the medicinal chemistry in recent 5 years［J］.Curr Med Chem，2021，28（14）：2807-2827.
LIU L，GAO H，WEN T，et al.Tanshinone ⅡA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation［J］.Pharm Biol，2021，59（1）：89-96.
ZHANG H，LI S，SI Y，et al.Andrographolide and its derivatives：Current achievements and future perspectives［J］.Eur J Med Chem，2021，224：113710.
YUAN M，MENG W，LIAO W，et al.Andrographolide antagonizes TNF-α-induced IL-8 via inhibition of NADPH oxidase/ROS/NF-κB and Src/MAPKs/AP-1 axis in human colorectal cancer HCT116 cells［J］.J Agric Food Chem，2018，66（20）：5139-5148.
Chen Y，Ji N，Pan S，et al.Roburic acid suppresses NO and IL-6 production via targeting NF-κB and MAPK pathway in RAW264.7 cells［J］.Inflammation，2017，40（6）：1959-1966.
XU H，LIU T，LI J，et al.Roburic acid targets TNF to inhibit the NF-κB signaling pathway and suppress human colorectal cancer cell growth［J］.Front Immunol，2022，13：853165.
BOOZARI M，HOSSEINZADEH H.Crocin molecular signaling pathways at a glance：A comprehensive review［J］.Phytother Res，2022，36（10）：3859-3884.
BAKSHI H A，QUINN G A，NASEF M M，et al.Crocin inhibits angiogenesis and metastasis in colon cancer via TNF-α/NF-κB/VEGF pathways［J］.Cells，2022，11（9）
LU Y，LIU Y，ZHOU J，et al.Biosynthesis，total synthesis，structural modifications，bioactivity，and mechanism of action of the quinone-methide triterpenoid celastrol［J］.Med Res Rev，2021，41（2）：1022-1060.
ZHANG H，ZHAO X，SHANG F，et al.Celastrol inhibits the proliferation and induces apoptosis of colorectal cancer cells via downregulating NF-κB/COX-2 signaling pathways［J］.Anticancer Agents Med Chem，2022，22（10）：1921-1932.
LI L，CHENG J，ZHU D，et al.The effects of Alisol B 23-acetate in hepatocellular carcinoma via inducing cell apoptosis and inhibiting cell migration and invasion［J］.Gen Physiol Biophys，2020，39（3）：219-228.
ZHU H C，JIA X K，FAN Y，et al.Alisol B 23-acetate ameliorates azoxymethane/dextran sodium sulfate-induced male murine colitis-associated colorectal cancer via modulating the composition of gut microbiota and improving intestinal barrier［J］.Front Cell Infect Microbiol，2021，11：640225.
PARK J H，KIM J K.Pristimerin，a naturally occurring triterpenoid，attenuates tumorigenesis in experimental colitis-associated colon cancer［J］.Phytomedicine，2018，42：164-171.
YOUSEF B A，HASSAN H M，ZHANG L Y，et al.Pristimerin exhibits in vitro and in vivo anticancer activities through inhibition of nuclear factor-кB signaling pathway in colorectal cancer cells［J］.Phytomedicine，2018，40：140-147.
CATANZARO E，CANISTRO D，PELLICIONI V，et al.Anticancer potential of allicin：A review［J］.Pharmacol Res，2022，177：106118.
HUANG W L，WU S F，XU S T，et al.Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF-κB signaling pathway［J］.J Food Sci，2020，85（6）：1924-1931.
Kiyonga AN，Park GH，Kim HS，et al.An efficient ionic liquid-mediated extraction and enrichment of isoimperatorin from Ostericum koreanum（Max.） Kitagawa［J］.Molecules，2021，26（21）：6555.
KIM N Y，JUNG Y Y，YANG M H，et al.Isoimperatorin down-regulates epithelial mesenchymal transition through modulating NF-κB signaling and CXCR4 expression in colorectal and hepatocellular carcinoma cells［J］.Cell Signal，2022，99：110433.
CHEN J M，CHEN P Y，LIN C C，et al.Antimetastatic effects of sesamin on human head and neck squamous cell carcinoma through regulation of matrix metalloproteinase-2［J］.Molecules，2020，25（9）：2248.
HUANG Y，LIU Z，LI L，et al.Sesamin inhibits hypoxia-stimulated angiogenesis via the NF-κB p65/HIF-1α/VEGFA signaling pathway in human colorectal cancer［J］.Food Funct，2022，13（17）：8989-8997.
BROCKMUELLER A，MUELLER A L，KUNNUMAKKARA A B，et al.Multifunctionality of Calebin A in inflammation，chronic diseases and cancer［J］.Front Oncol，2022，12：962066.
BUHRMANN C，SHAYAN P，BANIK K，et al.Targeting NF-κB signaling by Calebin A，a compound of turmeric，in multicellular tumor microenvironment：Potential role of apoptosis induction in CRC cells［J］.Biomedicines，2020，8（8）：236.
孙豪娴，孙贵香，朱莹.黄芩汤治疗溃疡性结肠炎的研究现状［J］.中国实验方剂学杂志，2022，28（23）：219-227.
HUANG J，JIANG T，KANG J，et al.Synergistic effect of huangqin decoction combined treatment with Radix Actinidiae chinensis on DSS and AOM-Induced colorectal cancer［J］.Front Pharmacol，2022，13：933070.
张传凤，刘博，葛雨竹，等.大黄牡丹汤对炎症相关性结直肠癌的治疗作用及对TLR4/My D88/NF-κB-p65信号通路的影响［J］.中国免疫学杂志，2021，37（12）：1443-1448.
SHAO S，JIA R，ZHAO L，et al.Xiao-Chai-Hu-Tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4/MyD88/NF-κB signaling pathway［J］.Phytomedicine，2021，88：153606.
LI Y，LI Z X，XIE C Y，et al.Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota［J］.World J Gastroenterol，2020，26（48）：7633-7651.
江东，程海波，沈卫星，等.参白解毒方抑制HCT116细胞增殖的药效及机制［J］.中国实验方剂学杂志，2022，28（13）：34-41.
姜瑞阳，徐长亮，程海波，等.缺氧微环境下仙连解毒方抑制结直肠癌细胞增殖的作用及机制［J］.中国实验方剂学杂志，2022，28（8）：79-85.
刘雷蕾，马淑然，王方园，等.芪贞汤对脂多糖诱导人结肠癌细胞上皮间充质转化的影响［J］.环球中医药，2019，12（2）：161-166.
LUO Q，HUANG S，ZHAO L，et al.Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NF-κB/STAT3 pathway in mice as revealed by network pharmacology study［J］.Front Pharmacol，2022，13：893231.
WAN G，XIE M，ZHANG X，et al.Chang-wei-qing，a Chinese herbal formula，ameliorates colitis-associated tumour development via inhibiting NF-B and STAT3 signalling pathway［J］.Pharm Biol，2019，57（1）：231-237.
王子元，孙明瑜，陈佳，等.健脾解毒方通过NF-κB/Nrf2/MRP2信号通路逆转大肠癌多药耐药的作用机制［J］.中华中医药杂志，2020，35（7）：3367-3371.
0
Views
20
下载量
1
CSCD
- H-PDFDownload
- L-PDFDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Postal code：100700
- Tel：010-84076882 Email：syfjx_2010@188.com
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
