Pathogenesis and Traditional Chinese Medicine Prevention and Treatment Strategy of Diabetic Vascular Calcification Based on Theory of Stasis-toxin-deficiency

WANG Wenting; LIU Yanfei; LI Yiwen; CHEN Keji; LIU Yue

doi:10.13422/j.cnki.syfjx.20231695

您当前的位置：

首页 >

文章列表页 >

Pathogenesis and Traditional Chinese Medicine Prevention and Treatment Strategy of Diabetic Vascular Calcification Based on Theory of Stasis-toxin-deficiency

更新时间：2023-08-22

- Pathogenesis and Traditional Chinese Medicine Prevention and Treatment Strategy of Diabetic Vascular Calcification Based on Theory of Stasis-toxin-deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 18, Pages: 183-189(2023)
- 作者机构：
  
  中国中医科学院西苑医院，国家中医心血管病临床医学研究中心，北京 100091
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20231695
  CLC： R22;R242;R2-031;R541.4;R749.1
- Published：20 September 2023，
  
  Published Online：16 March 2023，
  
  Received：01 December 2022，
- 稿件说明：
扫描看全文
王文婷,刘艳飞,李逸雯等.基于“瘀-毒-虚”探讨糖尿病血管钙化的发病机制及中医药防治策略[J].中国实验方剂学杂志,2023,29(18):183-189.

WANG Wenting,LIU Yanfei,LI Yiwen,et al.Pathogenesis and Traditional Chinese Medicine Prevention and Treatment Strategy of Diabetic Vascular Calcification Based on Theory of Stasis-toxin-deficiency[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(18):183-189.
王文婷,刘艳飞,李逸雯等.基于“瘀-毒-虚”探讨糖尿病血管钙化的发病机制及中医药防治策略[J].中国实验方剂学杂志,2023,29(18):183-189. DOI： 10.13422/j.cnki.syfjx.20231695.

WANG Wenting,LIU Yanfei,LI Yiwen,et al.Pathogenesis and Traditional Chinese Medicine Prevention and Treatment Strategy of Diabetic Vascular Calcification Based on Theory of Stasis-toxin-deficiency[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(18):183-189. DOI： 10.13422/j.cnki.syfjx.20231695.

摘要

血管并发症是导致糖尿病患者高致残率和死亡率的首要原因。血管钙化是糖尿病血管并发症重要的病理基础，其可显著增加糖尿病患者不良心血管事件的发生风险和血管重建术的实施困难，积极探索中西医结合防治策略具有重要的临床价值。该文以中医“瘀-毒-虚”理论的内涵阐释为切入点，深入探讨了“瘀-毒-虚”与糖尿病血管钙化发生发展的内在关联性，“瘀”与“毒”互为因果、胶结而患，“虚”为正气不足、气血偏失，三者皆与血脉疾病密切相关，从而创新性地提出了糖尿病血管钙化“瘀-毒-虚”的中医病机演变规律，即脉络瘀阻为发病之本，瘀毒互结为关键环节，中气匮乏为加重因素，同时提出运用“活血解毒、补虚通络”法防治糖尿病血管钙化的中医药干预策略，旨在为中西医结合防治糖尿病血管钙化的临床及转化研究提供理论依据。

Abstract

Vascular complications are the primary cause of the high disability and mortality in diabetic patients. Vascular calcification is a pathological basis of diabetic vascular complications and increases the risk of adverse cardiovascular events and the difficulty of revascularization in diabetic patients. It is of great clinical value to explore the measures for prevention and treatment of diabetic vascular calcification with integrated traditional Chinese and Western medicine. This paper explores the intrinsic association of stasis， toxin， and deficiency with diabetic vascular calcification to reveal the pathogenesis of diabetic vascular calcification. Stasis and toxin are causally affected by and combined with each other； deficiency refers to the deficiency of healthy Qi and the loss of Qi and blood. The three elements are associated with the occurrence and development of blood vessel diseases. This paper proposes the evolutional law of stasis， toxin， and deficiency in traditional Chinese medicine （TCM） for diabetic vascular calcification. Specifically， diabetic vascular calcification is rooted in the stasis of meridians and collaterals， develops due to the combination of stasis and toxin， and is aggravated by middle Qi deficiency. Furthermore， this paper proposes the TCM intervention principle of activating blood， removing toxin， tonifying deficiency， and dredging collaterals for the prevention and treatment of diabetic vascular calcification. The aim is to provide a theoretical basis for clinical and translational research on the prevention and treatment of diabetic vascular calcification with integrated Chinese and Western medicine.

关键词

糖尿病血管并发症血管钙化病因病机“瘀”“毒”“虚”

Keywords

diabetes mellitusvascular complicationvascular calcificationetiology and pathogenesisstasistoxindeficiency

references

MAGLIANO D J，BOYKO E J，IDF Diabetes Atlas 10th edition scientific committee.IDF Diabetes Atlas［M］.Brussels：International Diabetes Federation，2021.

中华医学会糖尿病学分会.中国2型糖尿病防治指南（2020年版）［J］.中华糖尿病杂志，2021，13（4）：315-409.

LEE S J，LEE I K，JEON J H.Vascular calcification-new insights into its mechanism［J］.Int J Mol Sci，2020，21（8）：2685.

YAO H，SUN Z，ZANG G，et al.Epidemiological research advances in vascular calcification in diabetes［J］.J Diabetes Res，2021，2021：4461311.

于思明，张显龙.中医药防治血管钙化的研究进展［J］.中西医结合心脑血管病杂志，2017，15（18）：2260-2263.

陈可冀，李连达，翁维良.血瘀证与活血化瘀研究［J］.中西医结合心脑血管病杂志，2005（1）：1-2.

孟锋，王笑红，卢红蓉.血瘀证源流考［J］.中国中医基础医学杂志，2020，26（5）：569-570，574.

张允岭，郭蓉娟，常富业，等.论中医毒邪的特性［J］.北京中医药大学学报，2007，30（12）：800-801.

张惜燕，邢玉瑞，胡勇.中医毒邪研究及相关问题探讨［J］.陕西中医药大学学报，2022，45（1）：48-52.

郑红斌.《黄帝内经》虚实病机述要［J］.中华中医药杂志，2017，32（9）：3913-3915.

李成卫.《黄帝内经》虚实词义延伸分析［J］.中国中医基础医学杂志，2012，18（7）：700-701.

夏洁楠，徐世杰.中医虚劳理论研究［D］.北京：中国中医科学院，2015.

QUAGLINO D，BORALDI F，LOFARO F D.The biology of vascular calcification［J］.Int Rev Cell Mol Biol，2020，354：261-353.

GHOSH S，LUO D，HE W，et al.Diabetes and calcification：The potential role of anti-diabetic drugs on vascular calcification regression［J］.Pharmacol Res，2020，158：104861.

SINGH A，TANDON S，TANDON C.An update on vascular calcification and potential therapeutics［J］.Mol Biol Rep，2021，48（1）：887-896.

DURHAM A L，SPEER M Y，SCATENA M，et al.Role of smooth muscle cells in vascular calcification：Implications in atherosclerosis and arterial stiffness［J］.Cardiovasc Res，2018，114（4）：590-600.

JAMINON A，REESINK K，KROON A，et al.The role of vascular smooth muscle cells in arterial remodeling：Focus on calcification-related processes［J］.Int J Mol Sci，2019，20（22）：5694.

JIANG H，LI L，ZHANG L，et al.Role of endothelial cells in vascular calcification［J］.Front Cardiovasc Med，2022，9：895005.

ZHANG L，YAO J，YAO Y，et al.Contributions of the endothelium to vascular calcification［J］.Front Cell Dev Biol，2021，9：620882.

YAHAGI K，KOLODGIE F D，LUTTER C，et al.ATVB in focus series on "Vascular Calcification in Diabetes"［J］.Arterioscl Throm Vas，2017，37（2）：191-204.

KAY A M，SIMPSON C L，STEWART J A.The role of AGE/RAGE signaling in diabetes-mediated vascular calcification［J］.J Diabetes Res，2016，2016：6809703.

BUNDY K，BOONE J，SIMPSON C L.Wnt signaling in vascular calcification［J］.Front Cardiovasc Med，2021，8：708470.

TYSON J，BUNDY K，ROACH C，et al.Mechanisms of the osteogenic switch of smooth muscle cells in vascular calcification：Wnt signaling，BMPs，mechanotransduction，and endMT［J］.Bioengineering （Basel），2020，7（3）：88.

WANG Z，ZHANG L，SUN Z，et al.Mechanisms of matrix vesicles mediating calcification transition in diabetic plaque［J］.Heart Lung Circ，2020，29（1）：112-117.

LANZER P，HANNAN F M，LANZER J D，et al.Medial arterial calcification：JACC state-of-the-art review［J］.J Am Coll Cardiol，2021，78（11）：1145-1165.

王景尚，殷惠军，陈可冀.活血化瘀法防治糖尿病血管病变作用机制的研究进展［J］.中国中西医结合杂志，2014，34（11）：1397-1400.

MUSHTAQ M，ABDUL MATEEN M，KIM U H.Hyperglycemia associated blood viscosity can be a nexus stimuli［J］.Clin Hemorheol Microcirc，2019，71（1）：103-112.

BIRO K，FEHER G，VEKASI J，et al.Hemorheological parameters in diabetic patients：Role of glucose lowering therapies［J］.Metabolites，2021，11（12）：806.

仝婉昱，ODURO PATRICK KWABENA，王芳，等.糖尿病血管重构机制及其药物防治的研究进展［J］.中南医学科学杂志，2022，50（1）：21-25.

KAUR R，KAUR M，SINGH J.Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus：Molecular insights and therapeutic strategies［J］.Cardiovasc Diabetol，2018，17（1）：121.

李圣耀，冒慧敏，薛梅，等.刍议瘀毒内涵及其在冠心病事件发生中的意义［J］.中国中西医结合杂志，2017，37（9）：1126-1128.

周秀娟，张攀，朱建伟，等.基于“脾气散精”理论探讨调节胰岛微循环及血糖波动的方法［J］.中医杂志，2018，59（17）：1470-1473.

王安娜，杨宇峰，石岩，等.2型糖尿病从脾论治理论探讨［J］.辽宁中医药大学学报，2022，24（2）：45-48.

段书众，于文会，张华，等.小檗碱通过PERK-ATF4通路对高糖诱导的血管平滑肌细胞钙化的改善作用［J］.中成药，2022，44（10）：3325-3328.

曾存良.黄连素通过MAPK信号通路抑制糖尿病大鼠主动脉钙化［D］.泸州：西南医科大学，2018.

张宜华.白藜芦醇抑制AGEs诱导泡沫细胞形成及血管平滑肌细胞钙化的机制研究［D］.重庆：第三军医大学，2010.

张彦燕，何丽，涂梦欣，等.红景天苷下调BMP2/Smad1信号抑制血管平滑肌细胞表型转化的作用［J］.西南民族大学学报：自然科学版，2020，46（6）：595-601.

白晓君，刘艳，郜珊珊，等.淫羊藿苷抑制氧化应激诱导主动脉血管平滑肌细胞钙化的机制研究［J］.中国中药杂志，2021，46（17）：4497-4503.

SONG Z，WEI D，CHEN Y，et al.Association of astragaloside Ⅳ-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling［J］.Toxicol Appl Pharmacol，2019，364：45-54.

钟慧，李带瑛，王苏樱，等.丹参酮ⅡA通过NF-κB和β-catenin信号通路抑制血管钙化［J］.生理学报，2022，74（6）：949-958.

LI H，YANG M.Ligustrazine activate the PPAR-γ pathway and play a protective role in vascular calcification［J］.Vascular，2022，30（6）：1224-1231.

邵静，陈安，张秀丽，等.吴茱萸次碱通过Sirt1改善血管平滑肌细胞钙化［J］.中山大学学报：医学科学版，2019，40（3）：387-392.

高帅，泮思林，杜占慧，等.地黄多糖抑制大鼠主动脉血管钙化的实验研究［J］.中华实验外科杂志，2021，38（8）：1466-1469.

胡艳红，杨静，修成奎，等.人参-三七-川芎提取物延缓高糖诱导的小鼠血管钙化的机制［J］.中国实验方剂学杂志，2020，26（8）：13-20.

史兆瑞，王军.糖尿病大血管纤维化探析及活血化瘀中药干预机制［J］.辽宁中医杂志，2020，47（5）：84-86.

吴小娟.活血化瘀药物治疗糖尿病大血管并发症研究进展［J］.实用中医药杂志，2017，33（2）：197-199.

黄晓芳，陈永华，倪洪岗，等.浅谈消渴病机中的阴虚生“毒”［J］.中医药信息，2020，37（1）：41-43.

梁清芝，冷玉琳，陈正涛，等.基于“伏毒损络”理论探讨糖尿病大血管病变的病机及治疗［J］.中国实验方剂学杂志，2022，28（14）：194-199.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Interpretation of Sinisan in Treatment of Diabetes Mellitus Complicated with Depression from Circular Motion Theory

Extraction Process and Mechanism of Active Ingredients of Mori Folium for Lowering Blood Glucose： A Review

Effect of Ferroptosis on Diabetes Mellitus and Its Complications and Intervention of Chinese Medicine： A Review

Cold and Heat in Acute Coronary Syndrome： A Review

Effect of South African Herb Hoodia gordonii on Liver Glucolipid Metabolism and PI3K/Akt/FoxO1 Signalling Pathway in db/db Mice

Related Author

LI Jiaxin

YAN Yupeng

LI Gaifen

JIA Haihua

LI Zhigeng

MIAO Qing

WU Meng

LU Zhengmin

Related Institution

Institute of Basic Theory of Traditional Chinese Medicine，China Academy of Chinese Medical Sciences

Beijing Research Institute of Chinese Medicine， Beijing University of Chinese Medicine

College of Life Sciences， Beijing University of Chinese Medicine

College of Chinese Materia Medica， Beijing University of Chinese Medicine

Gansu University of Traditional Chinese Medicine

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰