Clinical Efficacy of Huangqin Beimutang in Treatment of Chronic Rhinosinusitis in Children

SI Xiaoxue; HAN Xue; ZHAO Shanshan

doi:10.13422/j.cnki.syfjx.20231697

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Huangqin Beimutang in Treatment of Chronic Rhinosinusitis in Children

更新时间：2023-04-13

- Clinical Efficacy of Huangqin Beimutang in Treatment of Chronic Rhinosinusitis in Children
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 10, Pages: 160-165(2023)
- 作者机构：
  
  1.河南中医药大学儿科医学院，郑州 450000
  2.郑州大学附属儿童医院，郑州 450000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20231697
  CLC： R242;R2-0;R2-031;R72;R272;R765.4+1
- Published：20 May 2023，
  
  Published Online：14 March 2023，
  
  Received：04 January 2023，
- 稿件说明：
扫描看全文
四霄雪,韩雪,赵闪闪.黄芩贝母汤治疗儿童慢性鼻-鼻窦炎的临床疗效[J].中国实验方剂学杂志,2023,29(10):160-165.

SI Xiaoxue,HAN Xue,ZHAO Shanshan.Clinical Efficacy of Huangqin Beimutang in Treatment of Chronic Rhinosinusitis in Children[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(10):160-165.
四霄雪,韩雪,赵闪闪.黄芩贝母汤治疗儿童慢性鼻-鼻窦炎的临床疗效[J].中国实验方剂学杂志,2023,29(10):160-165. DOI： 10.13422/j.cnki.syfjx.20231697.

SI Xiaoxue,HAN Xue,ZHAO Shanshan.Clinical Efficacy of Huangqin Beimutang in Treatment of Chronic Rhinosinusitis in Children[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(10):160-165. DOI： 10.13422/j.cnki.syfjx.20231697.

摘要

目的

观察黄芩贝母汤治疗儿童慢性鼻-鼻窦炎的临床疗效。

方法

采用随机、对照的临床研究方法，将70例符合要求的慢性鼻-鼻窦炎患儿随机分为中药组和西药组，每组各35例。西药组患儿采用糠酸莫米松鼻喷雾剂喷鼻，每侧鼻孔1喷，每日1次，疗程为2周；小剂量口服阿奇霉素干混悬剂（4 mg·kg

-1

·d

-1

），每日1次，每周服用3 d，停药4 d，疗程为2周；中药组患儿采用口服黄芩贝母汤进行治疗，每日1剂，疗程2周。评估治疗前后中医主证及体征评分、症状视觉模拟量表（VAS）评分、鼻窦计算机断层扫描（CT）疗效评分，以及2组患儿中医证候临床疗效，记录不良反应事件的发生情况。

结果

中药组中医证候临床疗效总有效率为88.57%（31/35），西药组为71.43%（25/35），中药组总有效率高于西药组，差异有统计学意义（

8.458，

0.05）。与本组治疗前比较，2组患儿VAS评分、中医主证鼻塞及流涕评分、体征评分均显著降低（

0.01）；与西药组治疗后比较，中药组上述指标优于西药组（

0.05，

0.01）。与本组治疗前比较，西药组患儿头痛无明显改善，而中药组头痛评分显著降低（

0.01）。2组CT评分均有降低趋势，但差异无统计学意义。2组患儿治疗过程中均未出现不良反应。

结论

黄芩贝母汤可有效改善慢性鼻-鼻窦炎患儿临床症状，且安全有效。

Abstract

Object

To observe the clinical efficacy of Huangqin Beimutang on chronic rhinosinusitis in children.

Method

A randomized controlled trial （RCT） was conducted on 70 children who met the criteria for chronic rhinosinusitis， with 35 cases in the Chinese medicine group and 35 cases in the western medicine group. In the western medicine group，children received mometasone furoate nasal spray，one spray per nostril，once a day for two weeks， and also received a small dose of azithromycin suspension at 4 mg·kg

-1

·d

-1

，once a day，3 days a week for 2 weeks. The children in the Chinese medicine group were treated with oral Huangqin Beimutang，one dose per day for 2 weeks. Before and after treatment，the scores of primary symptoms and signs of traditional Chinese medicine （TCM），visual analogue scale （VAS） symptom scores，sinus computed tomography （CT） efficacy scores，and clinical efficacy of TCM syndromes in the two groups were evaluated，and the occurrence of adverse events was recorded.

Result

The total effective rate of clinical efficacy of TCM syndrome in the Chinese medicine group was 88.57% （31/35）， which was higher than 71.43% （25/35） in the western medicine group（

=8.458，

0.05）. The VAS scores， scores of TCM primary symptoms of nasal obstruction and runny nose， and physical sign scores in both groups were lower than those after treatment （

0.01）. The above indicators in the Chinese medicine group were superior to those in the western medicine group after treatment （

0.05，

0.01）. Compared with the conditions before treatment， there was no significant improvement in headache in the western medicine group， while the headache score in the Chinese medicine group decreased after treatment （

0.01）. The CT scores of the two groups showed a downward trend， but the difference was not statistically significant. There were no adverse reactions during treatment in both groups.

Conclusion

Huangqin Beimutang can effectively improve the clinical symptoms of patients with chronic rhinosinusitis， and it is safe and effective.

关键词

黄芩贝母汤儿童慢性鼻-鼻窦炎疗效观察

Keywords

Huangqin Beimutangchildrenchronic rhinosinusitisefficacy observation

references

中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组，中华医学会耳鼻咽喉头颈外科学分会鼻科学组.慢性鼻-鼻窦炎诊断和治疗指南（2012年，昆明）［J］.中华耳鼻咽喉头颈外科杂志，2013，48（2）：92-94.

沈翎，林宗通，林兴，等.伴上呼吸道疾病的儿童慢性鼻-鼻窦炎治疗探讨［J］.临床耳鼻咽喉头颈外科杂志，2017，31（6）：446-450，455.

刘爽，马文成，隋强，等.鼻窦炎口服液联合布地奈德超声雾化鼻吸入对慢性鼻-鼻窦炎术后患者黏膜形态和功能转归的影响［J］.陕西中医，2020，41（7）：929-931，944.

徐鑫铭，蔡纪堂，李静波，等.温阳止涕汤治疗肺气虚寒型慢性鼻窦炎的临床研究［J］.南京中医药大学学报，2022，38（2）：109-114.

叶建.消风宣窍汤联合阿奇霉素分散片治疗儿童慢性鼻窦炎风热犯肺证58例临床观察［J］.中医儿科杂志，2021，17（4）：62-66.

谢柳，谭业农，符国庆，等.清窍汤联合西药治疗对慢性鼻-鼻窦炎患者鼻腔菌群和鼻腔功能的影响［J］.西部中医药，2021，34（2）：92-95.

朱洪海，朱晓远，程根阳.鼻渊通窍颗粒对儿童慢性鼻窦炎鼻黏膜纤毛传输功能及炎性因子的影响［J］.中国实验方剂学杂志，2014，20（10）：188-191.

黄元御.黄元御医书全集［M］.北京：中医古籍出版社，2016：1222-1223.

刘蓬.中医耳鼻咽喉科学［M］.4版.北京：中国中医药出版社，2016：113-114.

郑筱萸.中药新药临床研究指导原则（试行）［M］.北京：中国医药科技出版社，2002：397.

国家中医药管理局.中医病证诊断疗效标准［S］.南京：南京大学出版社，1994.

孙悦奇，刘文龙，史剑波.儿童慢性鼻窦炎的相关研究进展［J］.中华耳鼻咽喉头颈外科杂志，2021，56（10）：1125-1130.

张婧，张东利，王旻.T细胞在慢性鼻窦炎中的作用机制［J］.中国耳鼻咽喉颅底外科杂志，2022，28（3）：106-110.

MARCUS S，DELGAUDIO J M，ROLAND L T，et al.Chronic rhinosinusitis：Does allergy play a role？［J］.Med Sci （Basel），2019，7（2）：30.

BOSE S，GRAMMER L C，PETERS A T.Infectious chronic rhinosinusitis［J］.J Allergy Clin Immunol Pract，2016，4（4）：584-589.

LELAND E M，ZHANG Z，KELLY K M，et al.Role of environmental air pollution in chronic rhinosinusitis［J］.Curr Allergy Asthma Rep，2021，21（8）：42.

HELMAN S N，BARROW E，EDWARDS T，et al.The role of allergic rhinitis in chronic rhinosinusitis［J］.Immunol Allergy Clin North Am，2020，40（2）：201-214.

BULFAMANTE A M，SAIBENE A M，FELISATI G，et al.Adenoidal disease and chronic rhinosinusitis in children-Is there a link？［J］.J Clin Med，2019，8（10）：1528.

张灵敏，李静波，蔡纪堂，等.加味化疔漏芦汤治疗慢性鼻-鼻窦炎伴分泌性中耳炎毒热证患者术后的康复及机制［J］.中国实验方剂学杂志，2020，26（17）：77-82.

MATUCCI A，BORMIOLI S，NENCINI F，et al.Asthma and chronic rhinosinusitis：How similar are they in pathogenesis and treatment responses？［J］.Int J Mol Sci，2021，22（7）：3340.

裴卓.60例儿童频频清嗓病因分析［J］.中国耳鼻咽喉头颈外科，2005，12（10）：673-674.

李华斌，王向东，王洪田，等.鼻炎分类和诊断及鼻腔用药方案的专家共识［J］.中国耳鼻咽喉颅底外科杂志，2019，25（6）：573-577.

陈海娟，侯艳鹏.鼻用糖皮质激素的常见不良反应［J］.中国药物滥用防治杂志，2022，28（1）：95-98.

褚连军.慢性鼻窦炎病原学特征及药敏结果分析［J］.中国病原生物学杂志，2022，17（6）：702-705.

骆平莉，殷婷.桉柠蒎肠溶软胶囊联合糠酸莫米松治疗慢性鼻炎的疗效观察［J］.现代药物与临床，2020，35（7）：1421-1425.

FOKKENS W J，LUND V J，HOPKINS C，et al.European position paper on rhinosinusitis and nasal polyps 2020［J］.Rhinology，2020，58（Suppl S29）：1-464.

JONES N S.Acute and chronic sinusitis in children［J］.Curr Opin Pulm Med，2000，6（3）：221-225.

李静波，王俊杰，蔡纪堂，等.加减舒中化痰汤替代激素治疗慢性鼻-鼻窦炎合并腺样体肥大患儿术后的临床疗效［J］.中国实验方剂学杂志，2021，27（2）：98-103.

汪文华，王广科，武天义，等.根治性鼻内镜手术治疗嗜酸粒细胞增高型慢性鼻窦炎伴鼻息肉的疗效分析［J］.临床耳鼻咽喉头颈外科杂志，2023，37（1）：20-24.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Observation of Modified Yinqiaosan Combined with Antibiotics in Treatment of Acute Tonsillitis in Children with Wind-heat Invading Lung Syndrome

Effect of Maxing Shigantang and Supplemented Guominjian Decoction on Symptoms and Inflammatory Cytokine Levels in Induced Sputum of Children with Cough Variant Asthma

Clinical Evidence of Chinese Patent Medicines in Treatment of Respiratory Diseases in Children： A Scoping Review

Sequential Treatment with Syndrome Differentiation on Children's Refractory Nephrotic Syndrome with Yiqi Huayu Qingre Prescription

Multicenter Randomized Controlled Clinical Trial of Longmu Zhuanggu Granule in Treatment of Children Recurrent Respiratory Infection with Lung-Spleen Qi Deficiency Syndrome

Related Author

QIAO Jinghua

YU Linlin

JING Xiaoping

DONG Xiaoyan

GU Mingda

QIU Zhikai

WANG Chunlian

YOU Shijun

Related Institution

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Children's Hospital of Shanghai， Children's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Jilin Academy of Traditional Chinese Medicine

Institute of Basic Theory for Chinese Medicine，China Academy of Chinese Medical Sciences

China Center for Evidence Based Traditional Chinese Medicine

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰