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Improvement of Colonic Mucosa Inflammatory Response in Mice with Ulcerative Colitis by Xiezhuo Jiedu Recipe Through miRNA-155-5p/JAK2/STAT3 Pathway
更新时间：2024-04-30
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    • Improvement of Colonic Mucosa Inflammatory Response in Mice with Ulcerative Colitis by Xiezhuo Jiedu Recipe Through miRNA-155-5p/JAK2/STAT3 Pathway

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    • “一项关于溃疡性结肠炎（UC）治疗机制的研究取得了重要进展。研究团队运用生物信息学方法，对UC活动期与缓解期之间的微小RNA（miRNAs）进行了深入分析。通过筛选差异表达基因（DEGs）并构建调控关系，推测了泄浊解毒方治疗UC的作用机制，并通过动物实验进行了验证。研究团队首先从基因表达数据库（GEO）中获取了UC患者结肠黏膜组织的miRNAs数据集。运用GEO2R、Excel等工具，筛选出了差异表达最显著的miRNAs作为研究对象。随后，运用多个数据库工具，筛选关键DEGs、预测下游转录因子（TF），并进行基因本体（GO）和京都基因与基因组百科全书（KEGG）富集分析。这些分析揭示了UC发生发展的关键信号通路。为了验证推测的作用机制，研究团队进行了动物实验。采用2.5%的葡聚糖硫酸钠（DSS）自由饮方式制备UC小鼠模型，并给予泄浊解毒方及美沙拉嗪灌胃7天。实验结果显示，泄浊解毒方能有效下调UC小鼠结肠组织中特定miRNA的表达，并调控关键信号通路相关蛋白的表达。这些变化有效提高了抑炎因子水平，减轻了炎症细胞浸润情况。这项研究不仅为UC的治疗提供了新的思路和方法，也为相关领域的研究开辟了新的方向。未来，有望通过进一步优化治疗方案，为UC患者带来更好的治疗效果。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 174-182(2024)

    • DOI：10.13422/j.cnki.syfjx.20231711    

      CLC： R284;R285;R289;R287;R22;R2-031;R33;R24

    • Published：05 June 2024，

      Published Online：08 December 2023，

      Received：21 September 2023，

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  • SUN Chaodi,ZHAO Mengmeng,LANG Xiaomeng,et al.Improvement of Colonic Mucosa Inflammatory Response in Mice with Ulcerative Colitis by Xiezhuo Jiedu Recipe Through miRNA-155-5p/JAK2/STAT3 Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):174-182. DOI： 10.13422/j.cnki.syfjx.20231711.

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