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Role of Ferroptosis in Cardiovascular Diseases and Chinese Medicine Treatment Based on Iron Homeostasis： A Review
增强出版- Chinese Journal of Experimental Traditional Medical Formulae Vol. 29, Issue 18, Pages: 198-208(2023)
- 作者机构：
1.辽宁中医药大学，沈阳 110847
2.辽宁中医药大学 附属医院，沈阳 110000
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20231823
CLC： R2-0;R22;R242;R2-031;R287Published：20 September 2023，
Published Online：27 July 2023，
Received：05 May 2023，
- 稿件说明：
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袁子阳,张艳,张伟.基于铁稳态代谢探讨铁死亡在心血管疾病中的作用及中医药治疗进展[J].中国实验方剂学杂志,2023,29(18):198-208.
YUAN Ziyang,ZHANG Yan,ZHANG Wei.Role of Ferroptosis in Cardiovascular Diseases and Chinese Medicine Treatment Based on Iron Homeostasis： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(18):198-208.
袁子阳,张艳,张伟.基于铁稳态代谢探讨铁死亡在心血管疾病中的作用及中医药治疗进展[J].中国实验方剂学杂志,2023,29(18):198-208. DOI： 10.13422/j.cnki.syfjx.20231823.
YUAN Ziyang,ZHANG Yan,ZHANG Wei.Role of Ferroptosis in Cardiovascular Diseases and Chinese Medicine Treatment Based on Iron Homeostasis： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(18):198-208. DOI： 10.13422/j.cnki.syfjx.20231823.
摘要
心血管疾病是一类涉及心脏及血管病变的循环系统疾病，主要包括心律失常、高血压病、冠心病、心肌梗死、心力衰竭等。心血管疾病的发病机制复杂，病种繁多，迁延难愈严重威胁着人类的健康，因此寻找一种行之有效的治疗方法迫在眉睫。铁死亡是一种有别于细胞自噬、凋亡的具有铁依赖性且伴随脂质过氧化物堆积等特点的新型细胞死亡方式。铁死亡发生机制复杂，新近研究表明铁稳态代谢对铁死亡发生具有重要作用，其可能从铁摄入、利用及输出、铁相关蛋白合成等多方面诱导铁死亡发生。此外铁稳态代谢和铁死亡已被证实参与心血管疾病的病理过程，因此调节心肌细胞铁稳态、改善铁死亡可能成为未来心血管疾病研究的重要靶点。中医药疗法是我国特有的治疗方式，其独特的辨证体系、治疗方法等已广泛应用于心血管疾病的防治及临床诊疗当中，具有独特优势。研究表明中药复方、中药单体及活性成分可特异性调节心肌细胞铁稳态影响铁死亡，起到保护心肌细胞的效果。该文从铁稳态代谢出发探讨铁稳态代谢调控铁死亡的作用机制，并对铁稳态代谢介导的铁死亡对心血管疾病的影响进行系统综述，同时结合中医药调节铁稳态代谢介导铁死亡在心血管疾病的研究进展，以期从铁稳态调控铁死亡角度为中医药防治心血管疾病提供新思路和方法。
Abstract
Cardiovascular diseases are a class of circulatory system diseases involving the heart and vessels， including arrhythmia， hypertension， coronary heart disease， myocardial infarction， heart failure and so on. Due to the complicated pathogenesis， diverse disease types， and difficult treatment， cardiovascular diseases pose serious threatens to the human health. Therefore， it is urgent to develop effective therapies. Ferroptosis， a new type of cell death different from autophagy and apoptosis， is iron-dependent and accompanied by lipid peroxide accumulation. The mechanism of ferroptosis is complex. Recent studies have shown that iron homeostasis plays a role in the occurrence of ferroptosis， which may be induced by iron intake， utilization， and output and iron-related protein synthesis. In addition， iron homeostasis and ferroptosis have been confirmed to be involved in the pathological process of cardiovascular diseases， so regulating iron homeostasis and ferroptosis in cardiomyocytes may be a focus of the future research on cardiovascular diseases. Traditional Chinese medicine （TCM） provides a unique treatment method， and the unique syndrome differentiation system and treatment methods have been widely used in the clinical diagnosis， prevention， and treatment of cardiovascular diseases. Studies have demonstrated that TCM compound prescriptions and the active components in Chinese medicinal materials can regulate iron homeostasis and ferroptosis to protect cardiomyocytes. This paper introduces the mechanism of iron homeostasis in regulating ferroptosis and summarizes the effects of iron homeostasis-mediated ferroptosis on cardiovascular diseases. Furthermore， the research progress of TCM in regulating iron homeostasis-mediated ferroptosis in cardiovascular diseases is reviewed to provide new ideas for TCM prevention and treatment of cardiovascular diseases.
关键词
铁稳态铁代谢铁死亡中医药心血管疾病
Keywords
iron homeostasisiron metabolismferroptosistraditional Chinese medicinecardiovascular disease
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