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1.中国中医科学院 中医基础理论研究所,北京 100700
2.北京中医药大学,北京 100029
3.四川大学 华西临床医学院,成都 610041
Received:14 August 2023,
Published Online:17 November 2023,
Published:20 February 2024
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袁雨露,杨桢,丁薇等.中药抗骨质疏松作用及机制探讨[J].中国实验方剂学杂志,2024,30(04):290-298.
YUAN Yulu,YANG Zhen,DING Wei,et al.Effect and Mechanism of Chinese Medicine in Treatment of Osteoporosis[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(04):290-298.
袁雨露,杨桢,丁薇等.中药抗骨质疏松作用及机制探讨[J].中国实验方剂学杂志,2024,30(04):290-298. DOI: 10.13422/j.cnki.syfjx.20231940.
YUAN Yulu,YANG Zhen,DING Wei,et al.Effect and Mechanism of Chinese Medicine in Treatment of Osteoporosis[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(04):290-298. DOI: 10.13422/j.cnki.syfjx.20231940.
骨质疏松(OP)是一种常见的骨骼疾病,严重影响患者生活,同时对患者及社会造成巨大的医疗负担。OP的发生有两种重要原因,即骨吸收过多、骨形成不足。外部钙离子平衡直接影响这两种原因。钙失衡会持续损害骨骼完整性,减少骨的钙供应,降低骨骼中的钙含量,进而引发OP。现代医学抗OP的主要干预措施是药物治疗,但药物治疗存在不良反应、药物依赖性等诸多问题。中药治疗OP的临床效果好、安全性高,适合长期使用。近年来研究表明,中药能改善雌激素缺乏、调节骨细胞及钙代谢,钙代谢对OP的形成和发展至关重要,瞬时受体电位(TRP)通道超家族成员TRPV5、TRPV6通过介导肠道钙离子跨膜转运(TRPV6)、肾脏钙离子跨膜转运(TRPV5)影响骨骼稳态。因此TRPV5/6是认识中药有效部位抗OP作用机制的关键靶点之一,值得深入研究。该文探讨了近二十年来有关中药抗OP作用的相关研究成果,尤其是中药对钙代谢调控的机制,为治疗OP的基础研究、临床应用及新药开发提供新的思路。
Osteoporosis (OP) is a common bone disease affecting the quality of life and causing huge medical burden to the patients and society. The occurrence of OP is mainly caused by excessive bone resorption and insufficient bone formation, which are directly influenced by external calcium ion balance. Calcium imbalance can impair bone integrity, reduce the calcium supply to the bone, and lower the calcium content in the bone, thus triggering OP. Drugs are the main anti-OP therapy in modern medicine, which, however, may cause adverse reactions and drug dependence. Chinese medicines have good clinical effects and high safety in treating OP, being suitable for long-term use. Recent studies have shown that Chinese medicines can alleviate estrogen deficiency, regulate bone cell and calcium metabolism, which is crucial for the formation and development of OP. The transient receptor potential cation channel superfamily V members 5 and 6 (TRPV5 and TRPV6, respectively) affect bone homeostasis by mediating the transmembrane calcium ion transport in the intestine (TRPV6) and kidney (TRPV5). Therefore, TRPV5/6 is one of the key targets to understand the anti-OP mechanisms of the effective parts of Chinese medicines, which is worthy of further study. This paper summarizes the research results about the anti-OP effects of Chinese medicines in the last two decades, especially the mechanism of regulating calcium metabolism, aiming to provide new ideas for the basic research, clinical application, and drug development of OP treatment.
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