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1.河北省中医院,石家庄 050000
2.石家庄市中医院,石家庄 050000
3.甘肃中医药大学,兰州 730000
4.甘肃省中医院,兰州 730000
Received:13 May 2023,
Published Online:22 August 2023,
Published:20 March 2024
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柴居堂,宁红霞,李永章等.中药干预细胞焦亡防治骨关节相关疾病机制研究进展[J].中国实验方剂学杂志,2024,30(06):289-298.
CHAI Jutang,NING Hongxia,LI Yongzhang,et al.Mechanism of Traditional Chinese Medicine Intervening in Pyroptosis to Prevent and Treat Bone and Joint Related Diseases: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(06):289-298.
柴居堂,宁红霞,李永章等.中药干预细胞焦亡防治骨关节相关疾病机制研究进展[J].中国实验方剂学杂志,2024,30(06):289-298. DOI: 10.13422/j.cnki.syfjx.20232021.
CHAI Jutang,NING Hongxia,LI Yongzhang,et al.Mechanism of Traditional Chinese Medicine Intervening in Pyroptosis to Prevent and Treat Bone and Joint Related Diseases: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(06):289-298. DOI: 10.13422/j.cnki.syfjx.20232021.
骨关节炎(OA)、类风湿关节炎(RA)、痛风性关节炎(GA)、椎间盘退变(IVDD)作为临床上最为常见的几种骨关节相关疾病,均可累及相关关节,导致关节疼痛、肿胀、功能障碍等症状,不同的是OA主要是由于关节磨损和年龄相关的退化导致的,表现为关节疼痛、僵硬和运动受限,RA是一种自身免疫性疾病,表现为关节疼痛、肿胀、晨僵和全身症状,GA是尿酸代谢异常引起的关节炎,表现为急性关节炎,而IVDD是椎间盘结构退行性变引起的。研究表明,上述骨关节疾病发生发展机制极其复杂,细胞焦亡通过参与骨关节炎症反应、软骨代谢失衡、细胞外基质降解、骨关节病理损伤与上述骨关节相关疾病密切相关,抑制骨关节相关细胞细胞焦亡将有效防治骨关节相关疾病。同时众多研究证实,中医药防治骨关节相关疾病疗效突出、优势明显,中医药能够通过抑制细胞焦亡,达到减轻骨关节炎症反应、改善骨关节疾病病理损伤、缓解骨关节疼痛的治疗作用。因此,该文以期通过阐述细胞焦亡与骨关节相关疾病发生发展的关系,并总结中药单体、中药提取物及中药复方干预细胞焦亡治疗骨关节相关疾病的最新研究报道,为骨关节疾病发病机制及药物治疗的深入研究提供新思路,为临床上运用中医药防治骨关节疾病提供依据。
Osteoarthritis (OA), rheumatoid arthritis (RA), gouty arthritis (GA), and intervertebral disc degeneration (IVDD) are the most common bone and joint-related diseases in clinical practice. They can all affect related joints, leading to joint pain, swelling, dysfunction, and other symptoms. The difference is that OA is mainly caused by joint wear and age-related degradation and is manifested as joint pain, stiffness, and limited movement. RA is an autoimmune disease, manifested as joint pain, swelling, morning stiffness, and systemic symptoms. GA is caused by abnormal uric acid metabolism, manifested as acute arthritis, and IVDD is caused by intervertebral disc degeneration. Studies have shown that the mechanism of the occurrence and development of these bone and joint diseases is extremely complex. Pyroptosis is closely related to these bone and joint-related diseases by participating in bone and joint inflammation, cartilage metabolism imbalance, extracellular matrix degradation, and pathological damage of bone and joint. Inhibition of bone and joint-related pyroptosis will effectively prevent and treat bone and joint-related diseases. At the same time, many studies have confirmed that traditional Chinese medicine (TCM) has a prominent curative effect and obvious advantages in the prevention and treatment of bone and joint-related diseases. TCM can reduce the inflammatory reaction of bone and joints, improve the pathological damage of bone and joint diseases, and relieve bone and joint pain by inhibiting pyroptosis. Therefore, this article aims to briefly explain the relationship between pyroptosis and the occurrence and development of bone and joint-related diseases and summarize the latest research reports on the intervention of pyroptosis in the treatment of bone and joint-related diseases by TCM monomers, TCM extracts, and TCM compounds. It offers new ideas for the in-depth study of the pathogenesis and drug treatment of bone and joint diseases and provides a basis for the clinical use of TCM to prevent and treat bone and joint diseases.
HUNTER D J , BIERMA-ZEINSTRA S . Osteoarthritis [J]. Lancet , 2019 , 393 ( 10182 ): 1745 - 1759 .
SAFIRI S , KOLAHI A A , SMITH E , et al . Global, regional and national burden of osteoarthritis 1990-2017: A systematic analysis of the global burden of disease study 2017 [J]. Ann Rheum Dis , 2020 , 79 ( 6 ): 819 - 828 .
王秋苑 , 刘又文 , 岳辰 , 等 . 细胞焦亡相关因子在类风湿关节炎患者中的表达及意义 [J]. 中国组织工程研究 , 2023 , 27 ( 32 ): 5209 - 5213 .
阳庆林 , 谢犇 , 杨杜斌 , 等 . 细胞焦亡在关节炎中的作用机制及研究进展 [J]. 中国医药导报 , 2023 , 20 ( 1 ): 49 - 52,60 .
周绪昌 , 曹红 , 徐玥 , 等 . 细胞焦亡在骨关节炎中的作用机制研究进展 [J]. 生命科学 , 2022 , 34 ( 4 ): 401 - 408 .
张皓博 , 赵宇楠 , 杨学军 . 细胞焦亡在椎间盘退变中的作用及治疗意义 [J]. 中国组织工程研究 , 2022 , 26 ( 9 ): 1445 - 1451 .
王欣波 , 霍佳敏 , 朴勇洙 , 等 . 国医大师卢芳运用四藤二龙汤治疗骨关节炎经验 [J]. 时珍国医国药 , 2022 , 33 ( 10 ): 2523 - 2524 .
李海 , 刘玉欢 , 赵文海 . 国医大师刘柏龄治疗类风湿性关节炎经验 [J]. 中华中医药杂志 , 2021 , 36 ( 7 ): 4002 - 4004 .
杜沁圆 , 秦聪聪 , 张义敏 , 等 . 基于阴阳理论研究中医药干预细胞焦亡的研究进展 [J]. 中国实验方剂学杂志 , 2022 , 28 ( 22 ): 276 - 282 .
王秋苑 , 刘又文 , 岳辰 , 等 . 中药对自身免疫性疾病细胞焦亡影响的研究进展 [J]. 中国实验方剂学杂志 , 2023 , 29 ( 2 ): 260 - 269 .
张团庄 , 宋渊 , 何志军 , 等 . 中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展 [J]. 中国实验方剂学杂志 , 2023 , 29 ( 22 ): 193 - 203 .
MAN S M , KARKI R , KANNEGANTI T D . Molecular mechanisms and functions of pyroptosis, inflammatory Caspases and inflammasomes in infectious diseases [J]. Immunol Rev , 2017 , 277 ( 1 ): 61 - 75 .
BERGSBAKEN T , FINK S L , COOKSON B T . Pyroptosis: Host cell death and inflammation [J]. Nat Rev Microbiol , 2009 , 7 ( 2 ): 99 - 109 .
LU F , LAN Z , XIN Z , et al . Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases [J]. J Cell Physiol , 2020 , 235 ( 4 ): 3207 - 3221 .
JIE F , XIAO S , QIAO Y , et al . Kuijieling decoction suppresses NLRP3-Mediated pyroptosis to alleviate inflammation and experimental colitis in vivo and in vitro [J]. J Ethnopharmacol , 2021 , 264 : 113243 .
ZHAO J , JIANG P , GUO S , et al . Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis [J]. Front Immunol , 2021 , 12 : 809806 .
WANG S , MOBASHERI A , ZHANG Y , et al . Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway [J]. Inflammopharmacology , 2021 , 29 ( 3 ): 695 - 704 .
WU D , LI Y , XU R . Can pyroptosis be a new target in rheumatoid arthritis treatment? [J]. Front Immunol , 2023 , 14 : 1155606 .
ZHAO J , WEI K , JIANG P , et al . Inflammatory response to regulated cell death in gout and its functional implications [J]. Front Immunol , 2022 , 13 : 888306 .
GE Y , CHEN Y , GUO C , et al . Pyroptosis and intervertebral disc degeneration: Mechanistic insights and therapeutic implications [J]. J Inflamm Res , 2022 , 15 : 5857 - 5871 .
CHARLTON J M , ESCULIER J F , KOBSAR D , et al . Symptomatic knee osteoarthritis is associated with worse but stable quality of life and physical function regardless of the compartmental involvement: Data from the OAI [J]. Osteoarthr Cartil Open , 2020 , 2 ( 4 ): 100117 .
KATZ J N , ARANT K R , LOESER R F . Diagnosis and treatment of Hip and knee osteoarthritis: A review [J]. JAMA , 2021 , 325 ( 6 ): 568 - 578 .
JAGGARD M K J , BOULANGÉ C L , GRAÇA G , et al . Can metabolic profiling provide a new description of osteoarthritis and enable a personalised medicine approach? [J]. Clin Rheumatol , 2020 , 39 ( 12 ): 3875 - 3882 .
ZHANG L , ZHANG L , HUANG Z , et al . Increased HIF-1 α in knee osteoarthritis aggravate synovial fibrosis via fibroblast-like synoviocyte pyroptosis [J]. Oxid Med Cell Longev , 2019 , 2019 : 6326517 .
LI Z , HUANG Z , BAI L . The P2X7 receptor in osteoarthritis [J]. Front Cell Dev Biol , 2021 , 9 : 628330 .
HU Q , ECKER M . Overview of MMP-13 as a promising target for the treatment of osteoarthritis [J]. Int J Mol Sci , 2021 , 22 ( 4 ): 1742 .
LI Z , HUANG Z , ZHANG H , et al . P2X7 receptor induces pyroptotic inflammation and cartilage degradation in osteoarthritis via NF- κ B/NLRP3 crosstalk [J]. Oxid Med Cell Longev , 2021 , 2021 : 8868361 .
PARK K A , VASKO M R . Lipid mediators of sensitivity in sensory neurons [J]. Trends Pharmacol Sci , 2005 , 26 ( 11 ): 571 - 577 .
AN S , HU H , LI Y , et al . Pyroptosis plays a role in osteoarthritis [J]. Aging Dis , 2020 , 11 ( 5 ): 1146 - 1157 .
WANG Q , YING L , WEI B , et al . Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis [J]. J Biochem Mol Toxicol , 2022 , 36 ( 2 ): e22951 .
TIAN Y , FENG X , ZHOU Z , et al . Ginsenoside compound K ameliorates osteoarthritis by inhibiting the chondrocyte endoplasmic reticulum stress-mediated IRE1 α -TXNIP-NLRP3 axis and pyroptosis [J]. J Agric Food Chem , 2023 , 71 ( 3 ): 1499 - 1509 .
ZU Y , MU Y , LI Q , et al . Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis [J]. J Orthop Surg Res , 2019 , 14 ( 1 ): 307 .
HU J , ZHOU J , WU J , et al . Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF- κ B activity and pyroptosis in chondrocytes [J]. J Ethnopharmacol , 2020 , 247 : 112261 .
YU H , YAO S , ZHOU C , et al . Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF- κ B signaling [J]. J Ethnopharmacol , 2021 , 266 : 113447 .
蔡猛 , 张永宁 . 三七总皂苷调控TLR4/NLRP3/Caspase-1信号通路对骨关节炎大鼠软骨细胞焦亡的影响 [J]. 中医药信息 , 2023 , 40 ( 2 ): 11 - 17 .
林晴 , 潘丹虹 , 李路 , 等 . 荣筋拈痛方调控软骨细胞NLRP3/Caspase-1/GSDMD通路改善骨关节炎炎性病变的机制 [J]. 中华中医药杂志 , 2022 , 37 ( 10 ): 5653 - 5658 .
杨洋 , 梅胜 , 辛龙 . 桂枝附子汤调控TXNIP/NLRP3/Caspase-1通路抑制软骨细胞焦亡的机制研究 [J]. 现代实用医学 , 2021 , 33 ( 6 ): 709 - 712,696 .
谢芳 , 刘永利 , 李树冬 , 等 . 活膝汤对膝骨关节炎模型大鼠软骨细胞焦亡的作用机制 [J]. 湖南中医药大学学报 , 2023 , 43 ( 2 ): 225 - 231 .
金灵璐 , 付长龙 , 涂海水 , 等 . 乌头汤对膝骨关节炎大鼠软骨细胞焦亡相关基因表达的影响 [J]. 风湿病与关节炎 , 2023 , 12 ( 3 ): 1 - 4,12 .
ALETAHA D , SMOLEN J S . Diagnosis and management of rheumatoid arthritis: A review [J]. JAMA , 2018 , 320 ( 13 ): 1360 - 1372 .
CHEN Z , BOZEC A , RAMMING A , et al . Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis [J]. Nat Rev Rheumatol , 2019 , 15 ( 1 ): 9 - 17 .
YI Y S . Role of inflammasomes in inflammatory autoimmune rheumatic diseases [J]. Korean J Physiol Pharmacol , 2018 , 22 ( 1 ): 1 - 15 .
ZU S Q , FENG Y B , ZHU C J , et al . Acid-sensing ion channel 1a mediates acid-induced pyroptosis through Calpain-2/calcineurin pathway in rat articular chondrocytes [J]. Cell Biol Int , 2020 , 44 ( 10 ): 2140 - 2152 .
SPEL L , MARTINON F . Inflammasomes contributing to inflammation in arthritis [J]. Immunol Rev , 2020 , 294 ( 1 ): 48 - 62 .
MOTTA F , BARONE E , SICA A , et al . Inflammaging and osteoarthritis [J]. Clin Rev Allergy Immunol , 2023 , 64 ( 2 ): 222 - 238 .
SIEBERT S , TSOUKAS A , ROBERTSON J , et al . Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases [J]. Pharmacol Rev , 2015 , 67 ( 2 ): 280 - 309 .
YAMAZAKI H , TAKEOKA M , KITAZAWA M , et al . ASC plays a role in the priming phase of the immune response to type Ⅱ collagen in collagen-induced arthritis [J]. Rheumatol Int , 2012 , 32 ( 6 ): 1625 - 1632 .
LI Q , SHI N , CAI C , et al . The role of mitochondria in pyroptosis [J]. Front Cell Dev Biol , 2020 , 8 : 630771 .
LIEBERMAN J , WU H , KAGAN J C . Gasdermin D activity in inflammation and host defense [J]. Sci Immunol , 2019 , 4 ( 39 ): eaav1447 .
ZHAI Z , YANG F , XU W , et al . Attenuation of rheumatoid arthritis through the inhibition of tumor necrosis factor-induced Caspase 3/gasdermin E-mediated pyroptosis [J]. Arthritis Rheumatol , 2022 , 74 ( 3 ): 427 - 440 .
GE G , BAI J , WANG Q , et al . Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF- κ B signaling pathway [J]. Sci China Life Sci , 2022 , 65 ( 3 ): 588 - 603 .
XU L , WANG H , YU Q Q , et al . The monomer derivative of paeoniflorin inhibits macrophage pyroptosis via regulating TLR4/ NLRP3/ GSDMD signaling pathway in adjuvant arthritis rats [J]. Int Immunopharmacol , 2021 , 101 ( Pt A ): 108169 .
LI W , WANG K , LIU Y , et al . A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4/NF κ B/NLRP3 activation-induced pyroptosis [J]. Front Immunol , 2022 , 13 : 912933 .
LING Y , XIAO M , HUANG Z W , et al . Jinwujiangu capsule treats fibroblast-like synoviocytes of rheumatoid arthritis by inhibiting pyroptosis via the NLRP3/CAPSES/GSDMD pathway [J]. Evid Based Complement Alternat Med , 2021 , 2021 : 4836992 .
李楠 , 马庆宇 , 韩隆胤 , 等 . 补肾活血法对类风湿关节炎软骨细胞焦亡及HMGB1/NLRP3信号通路的影响 [J]. 中华中医药杂志 , 2022 , 37 ( 4 ): 1929 - 1933 .
张铭 , 吴天宇 , 刘小碣 , 等 . 甘草附子汤加减方通过抑制GSDMD介导的焦亡治疗CIA大鼠的作用机制研究 [J]. 中国病理生理杂志 , 2023 , 39 ( 2 ): 325 - 334 .
尚碧月 , 姜泉 , 夏聪敏 , 等 . 基于细胞焦亡探讨中药复方对CIA大鼠炎症的影响 [J]. 中国中医基础医学杂志 , 2023 , 29 ( 4 ): 593 - 597 .
王露琳 , 汪元 , 刘健 , 等 . 新风胶囊含药血清抑制脂多糖诱导的类风湿关节炎大鼠的滑膜成纤维细胞焦亡 [J]. 南方医科大学学报 , 2022 , 42 ( 12 ): 1846 - 1851 .
吴宁 , 袁桃花 , 姬进忠 , 等 . 苗药验方四大血对人类风湿性关节炎成纤维样滑膜细胞凋亡和焦亡的影响 [J]. 南方医科大学学报 , 2021 , 41 ( 10 ): 1473 - 1483 .
王秋苑 , 岳辰 , 刘又文 , 等 . 顽痹清丸对类风湿关节炎湿热痹阻证患者血清细胞焦亡相关因子表达的影响 [J]. 中医杂志 , 2023 , 64 ( 12 ): 1240 - 1247 .
彭程 , 高明利 , 于静 , 等 . 基于NLRP3/Caspase-1信号通路影响软骨细胞焦亡探讨独活寄生汤干预类风湿关节炎作用机制 [J]. 辽宁中医药大学学报 , 2021 , 23 ( 9 ): 32 - 36 .
ZHOU M , LIU C , GUO Y , et al . HQL6 serves as a novel P2Y(14) receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis [J]. Int Immunopharmacol , 2023 , 114 : 109507 .
HAO K , JIANG W , ZHOU M , et al . Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis [J]. Int J Biol Sci , 2020 , 16 ( 16 ): 3163 - 3173 .
WANG H Y , LIN X , HUANG G G , et al . Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases [J]. Acta Pharmacol Sin , 2023 , 44 ( 8 ): 1687 - 1700 .
TIAN J , ZHOU D , XIANG L , et al . Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF- κ B and p62-Keap1 pathways [J]. Drug Dev Res , 2022 , 83 ( 7 ): 1654 - 1672 .
LUO T , ZHOU X , QIN M , et al . Corilagin restrains NLRP3 inflammasome activation and pyroptosis through the ROS/TXNIP/NLRP3 pathway to prevent inflammation [J]. Oxid Med Cell Longev , 2022 , 2022 : 1652244 .
LIN Y , LUO T , WENG A , et al . Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling [J]. Front Immunol , 2020 , 11 : 580593 .
CUNHA C , SILVA A J , PEREIRA P , et al . The inflammatory response in the regression of lumbar disc herniation [J]. Arthritis Res Ther , 2018 , 20 ( 1 ): 251 .
LIAO Z , LI S , LIU R , et al . Autophagic degradation of gasdermin D protects against nucleus pulposus cell pyroptosis and retards intervertebral disc degeneration in vivo [J]. Oxid Med Cell Longev , 2021 , 2021 : 5584447 .
HE D , ZHOU M , BAI Z , et al . Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway [J]. Biochem Biophys Res Commun , 2020 , 526 ( 3 ): 772 - 779 .
SBORGI L , RÜHL S , MULVIHILL E , et al . GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death [J]. EMBO J , 2016 , 35 ( 16 ): 1766 - 1778 .
JIA Y , CUI R , WANG C , et al . Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway [J]. Redox Biol , 2020 , 32 : 101534 .
ZHAO K , AN R , XIANG Q , et al . Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration [J]. Cell Prolif , 2021 , 54 ( 1 ): e12941 .
GONG Y , QIU J , JIANG T , et al . Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/Akt/NF- κ B pathway and regulating NLRP3 inflammasome-mediated pyroptosis [J]. Inflammopharmacology , 2023 , 31 ( 1 ): 369 - 384 .
TANG K , SU W , HUANG C , et al . Notoginsenoside R 1 suppresses inflammatory response and the pyroptosis of nucleus pulposus cells via inactivating NF- κ B/NLRP3 pathways [J]. Int Immunopharmacol , 2021 , 101 ( Pt B ): 107866 .
DAI W Y , LUO Z P . Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats [J]. Cell Signal , 2022 , 91 : 110243 .
尹逊路 , 金哲峰 , 冯敏山 , 等 . 补肾活血方对椎间盘退行性变大鼠髓核细胞焦亡的影响 [J]. 中国中医药信息杂志 , 2021 , 28 ( 12 ): 36 - 40 .
吴子健 , 胡昭端 , 周晓红 , 等 . 通督活血汤含药血清可抑制椎间盘纤维环细胞的焦亡 [J]. 中国组织工程研究 , 2021 , 25 ( 14 ): 2148 - 2154 .
冯蓬 , 朱立国 , 高春雨 , 等 . 壮腰通络方对椎间盘退变大鼠髓核细胞焦亡的影响 [J]. 中国中医药信息杂志 , 2023 , 30 ( 10 ): 89 - 94 .
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