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Mechanism of Xibining Ⅱ Combined with ADSC-Exos in Improving Knee Osteoarthritis by Regulating Mitochondrial Autophagy
更新时间：2024-04-30
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    • Mechanism of Xibining Ⅱ Combined with ADSC-Exos in Improving Knee Osteoarthritis by Regulating Mitochondrial Autophagy

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    • “科技新闻播报：针对膝骨关节炎（KOA）的治疗机制，一项研究取得了重要进展。该研究通过深入观察膝痹宁Ⅱ及脂肪干细胞外泌体（ADSC-Exos）单独及联合应用对软骨退变及线粒体自噬的影响，揭示了它们改善KOA的潜在机制。专家团队精心设计了实验方案，将40只SD大鼠分为五组，通过前交叉韧带切断术（ACLT）建立KOA模型，并评估了大鼠的痛敏状态和膝关节及软骨组织的退变程度。同时，利用多种先进技术，如免疫荧光、酶联免疫吸附测定法和蛋白免疫印迹法，深入探讨了相关生物标志物的变化情况。研究结果显示，膝痹宁Ⅱ和ADSC-Exos均能有效提升软骨细胞线粒体自噬水平，从而延缓软骨组织退变。二者联合使用时，效果更为显著。这一发现为KOA的治疗提供了新的策略，有望为众多患者带来福音。该研究的成功实施，不仅为KOA的治疗领域带来了新的突破，也为其他相关疾病的研究提供了有益的借鉴。未来，随着这一机制的深入研究，我们有望见证更多创新治疗方法的诞生。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 111-119(2024)

    • DOI：10.13422/j.cnki.syfjx.20232241    

      CLC： R2-0;R33;R289;R684.3

    • Published：05 June 2024，

      Published Online：09 January 2024，

      Received：23 October 2023，

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  • KANG Junfeng,JIE Lishi,FU Houyu,et al.Mechanism of Xibining Ⅱ Combined with ADSC-Exos in Improving Knee Osteoarthritis by Regulating Mitochondrial Autophagy[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):111-119. DOI： 10.13422/j.cnki.syfjx.20232241.

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